{"id":100733,"date":"2020-10-30T00:37:24","date_gmt":"2020-10-29T21:37:24","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/crispr-gene-editing-mistake-results-in-over-a-dozen-mutant-embryos\/"},"modified":"2020-10-30T00:37:24","modified_gmt":"2020-10-29T21:37:24","slug":"crispr-gene-editing-mistake-results-in-over-a-dozen-mutant-embryos","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/crispr-gene-editing-mistake-results-in-over-a-dozen-mutant-embryos\/","title":{"rendered":"#CRISPR gene-editing mistake results in over a dozen mutant embryos"},"content":{"rendered":"

“#CRISPR gene-editing mistake results in over a dozen mutant embryos<\/strong>”
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\n Scientists using a controversial gene-editing device unwittingly created more than a dozen mutant human embryos, according to a new study.<\/p>\n

In an effort to repair a gene that causes blindness, researchers using a CRISPR DNA-cutting machine accidentally got rid of entire chromosomes, or large chunks of them, according to a study published Thursday in the journal Cell<\/a>.<\/p>\n

For the study, researchers at an undisclosed lab collected sperm from a man with hereditary blindness to create 40 embryos.<\/p>\n

They then used a CRISPR-Cas9 tool \u2014 which functions like a microscopic scalpel \u2014 to cut out the gene mutation they wanted to correct in 37 of the embryos. The remaining three were serving as controls.<\/p>\n

But about half of the embryos lost an entire chromosome, or large swaths of it, on the gene where the mutation causing blindness was located, according to the study.<\/p>\n

Removed or damaged chromosomes can result in genetic abnormalities that can be passed on to future generations.<\/p>\n

\u201cThis is a very adverse outcome,\u201d study author Dieter Egli, of Columbia University, told the Wall Street Journal<\/a>.<\/p>\n

The findings also show the \u201cthe human embryo seems unique in its poor ability to fix a DNA break,\u201d Egli said, who added that it goes \u201cbeyond the debate\u201d over the use of CRISPR in pregnancies.<\/p>\n

Scientists have for years debated whether CRISPR is safe and effective enough to use on human embryos that will eventually grow into babies.<\/p>\n

Critics point to studies showing the technology<\/a> can cause cancer, while others argue that it is not yet precise enough.<\/p>\n

Other skeptics take issue with the ethics of allowing scientists to \u201cplay God.<\/a>\u201d<\/p>\n

Last month, a group sponsored by the US National Academy of Medicine published a report saying the technology isn\u2019t ready to be used on embryos because scientists don\u2019t yet know how to use it without introducing potentially dangerous DNA changes.\n <\/p><\/div>\n

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If you want to read more News<\/a> articles, you can visit our News category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n

Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

“#CRISPR gene-editing mistake results in over a dozen mutant embryos” Scientists using a controversial gene-editing device unwittingly created more than a dozen mutant human embryos, according to a new study. In an effort to repair a gene that causes blindness, researchers using a CRISPR DNA-cutting machine accidentally got rid of entire chromosomes, or large chunks…<\/p>\n","protected":false},"author":1,"featured_media":100734,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2020\/10\/dna-crispr-01.jpg?quality=90&strip=all&w=1200","fifu_image_alt":"","footnotes":""},"categories":[70897],"tags":[77574,70508,5050],"class_list":["post-100733","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-10-29-20","tag-dna","tag-scientists"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/100733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=100733"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/100733\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/100734"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=100733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=100733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=100733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}