{"id":108054,"date":"2020-11-09T01:38:55","date_gmt":"2020-11-08T22:38:55","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/moriarty-the-patriot-a-study-in-quinine\/"},"modified":"2020-11-09T01:38:55","modified_gmt":"2020-11-08T22:38:55","slug":"moriarty-the-patriot-a-study-in-quinine","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/moriarty-the-patriot-a-study-in-quinine\/","title":{"rendered":"#Moriarty the Patriot: A Study in Quinine"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a2ffbbbba251\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a2ffbbbba251\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/moriarty-the-patriot-a-study-in-quinine\/#What_actually_is_quinine\" >What actually is quinine?\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/moriarty-the-patriot-a-study-in-quinine\/#How_does_all_this_tie_in_with_grapefruit_juice\" >How does all this tie in with grapefruit juice?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/moriarty-the-patriot-a-study-in-quinine\/#So_why_quinine_instead_of_quinidine_in_Moriarty_the_Patriot\" >So, why quinine instead of quinidine in Moriarty the Patriot?\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/buradabiliyorum.com\/en\/moriarty-the-patriot-a-study-in-quinine\/#Was_it_realistic_for_Moriarty_to_know_about_grapefruit_juices_side-effect\" >Was it realistic for Moriarty to know about grapefruit juice\u2019s side-effect?<\/a><\/li><\/ul><\/nav><\/div>\n<p>&#8220;<strong>#Moriarty the Patriot: A Study in Quinine<\/strong>&#8221;<\/p>\n<div>\n<p><span style=\"font-size: 12pt;\"><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"font-weight: 400;\">This week on <\/span><i><span style=\"font-weight: 400;\">Moriarty the Patriot<\/span><\/i><\/span><span style=\"font-weight: 400;\"><span style=\"font-family: arial, helvetica, sans-serif;\">, the show\u2019s elusive criminal consultant orchestrates yet another grand homicide for the sake of the lower class. The gardener Burton and his wife Michelle have just lost their sick child because of the Viscount of Belfor\u2019s refusal to let him be treated. Upon hearing their story, Moriarty provides them a plan to kill the Viscount, one that turns his own heart condition against him rather than endangering the lives of Burton and Michelle. So as long as they played their roles correctly, Burton and Michelle would finally be freed from their grief and remorse.<\/span> <\/span><\/span><\/p>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-attachment-id=\"12417\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_study-in-quinine\/\" data-orig-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Study in Quinine\" data-image-description=\"\" data-medium-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" width=\"696\" height=\"392\" alt=\"\" class=\"wp-image-12417 jetpack-lazy-image\" data-recalc-dims=\"1\" srcset=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?w=1440&amp;ssl=1 1440w\" data-lazy-sizes=\"(max-width: 696px) 100vw, 696px\" src=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=696%2C392&amp;is-pending-load=1#038;ssl=1\"\/><noscript><img decoding=\"async\" data-attachment-id=\"12417\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_study-in-quinine\/\" data-orig-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Study in Quinine\" data-image-description=\"\" data-medium-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" width=\"696\" height=\"392\" src=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=696%2C392&amp;ssl=1\" alt=\"\" class=\"wp-image-12417\" srcset=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Study-in-Quinine.png?w=1440&amp;ssl=1 1440w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" data-recalc-dims=\"1\"\/><\/noscript><\/figure>\n<p><span style=\"font-weight: 400; font-family: arial, helvetica, sans-serif; font-size: 12pt;\">Even though I enjoy Moriarty\u2019s nefarious schemes to take down the nobles, this one takes a special place in my heart because it\u2019s medical-related. It is not a coincidence nor a contrived plot point that grapefruit juice is introduced as the crux to \u201ckill\u201d the Viscount. There is actual <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a> behind the complex relationship of quinine and grapefruits that is still being discussed today, so let\u2019s take a quick dive into it.<\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_actually_is_quinine\"><\/span><span style=\"font-family: arial, helvetica, sans-serif; font-size: 18pt; color: #333333;\"><b>What actually is quinine?<\/b><i><span style=\"font-weight: 400;\">\u00a0<\/span><\/i><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img decoding=\"async\" data-attachment-id=\"12416\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_quinine\/\" data-orig-file=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Quinine\" data-image-description=\"\" data-medium-file=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" alt=\"\" class=\"wp-image-12416 jetpack-lazy-image\" width=\"377\" height=\"212\" data-recalc-dims=\"1\" srcset=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?w=1440&amp;ssl=1 1440w\" data-lazy-sizes=\"(max-width: 377px) 100vw, 377px\" src=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=377%2C212&amp;is-pending-load=1#038;ssl=1\"\/><noscript><img decoding=\"async\" data-attachment-id=\"12416\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_quinine\/\" data-orig-file=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Quinine\" data-image-description=\"\" data-medium-file=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" src=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=377%2C212&amp;ssl=1\" alt=\"\" class=\"wp-image-12416\" width=\"377\" height=\"212\" srcset=\"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Quinine.png?w=1440&amp;ssl=1 1440w\" sizes=\"auto, (max-width: 377px) 100vw, 377px\" data-recalc-dims=\"1\"\/><\/noscript><\/figure>\n<\/div>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><span style=\"font-weight: 400;\">As described in the <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/anime-manga\/\" data-internallinksmanager029f6b8e52c=\"6\" title=\"Anime || Manga\" target=\"_blank\" rel=\"noopener\">anime<\/a>, <\/span><b>quinine<\/b><span style=\"font-weight: 400;\"> is an anti-malarial drug. The compound is a natural extract from the bark of the cinchona tree in Peru, and has been in circulation since the Jesuit missionaries brought it back to Europe in 1636. However, by the 1800s, the bitter-tasting quinine became lauded as a wonder drug in tonic waters to help with irregular heart palpitations and muscle cramps. It also has an \u201cisomer,\u201d which is a different structure or orientation of the compound that may result in vastly different properties. This isomer is <\/span><b>quinidine<\/b><span style=\"font-weight: 400;\"> and is known to also be anti-malarial and treat irregular heart conditions better than quinine. <\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_does_all_this_tie_in_with_grapefruit_juice\"><\/span><strong><span style=\"font-size: 18pt; font-family: arial, helvetica, sans-serif; color: #333333;\">How does all this tie in with grapefruit juice?<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-large is-resized\"><img decoding=\"async\" data-attachment-id=\"12418\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_grapefruit\/\" data-orig-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Grapefruit\" data-image-description=\"\" data-medium-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" alt=\"\" class=\"wp-image-12418 jetpack-lazy-image\" width=\"348\" height=\"195\" data-recalc-dims=\"1\" srcset=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?w=1440&amp;ssl=1 1440w\" data-lazy-sizes=\"(max-width: 348px) 100vw, 348px\" src=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=348%2C195&amp;is-pending-load=1#038;ssl=1\"\/><noscript><img decoding=\"async\" data-attachment-id=\"12418\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_grapefruit\/\" data-orig-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Grapefruit\" data-image-description=\"\" data-medium-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" src=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=348%2C195&amp;ssl=1\" alt=\"\" class=\"wp-image-12418\" width=\"348\" height=\"195\" srcset=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Grapefruit.png?w=1440&amp;ssl=1 1440w\" sizes=\"auto, (max-width: 348px) 100vw, 348px\" data-recalc-dims=\"1\"\/><\/noscript><\/figure>\n<\/div>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><span style=\"font-weight: 400;\">In <\/span><i><span style=\"font-weight: 400;\">Moriarty the Patriot<\/span><\/i><span style=\"font-weight: 400;\">, the Viscount ingested both the quinine and the grapefruit juice during a moment of panic that caused his heart palpitations. As it turns out, grapefruit juice contains a component known as furanocoumarins. This chemical can block the CYP3A4 in your body, an enzyme that metabolizes many medications today. Medical practitioners <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/general\/\" data-internallinksmanager029f6b8e52c=\"3\" title=\"General\" target=\"_blank\" rel=\"noopener\">general<\/a>ly advise against drinking grapefruit juice in conjunction with prescribed medication to prevent contraindications. Unfortunately, the Viscount had no knowledge of this and upon drinking the grapefruit juice, he eventually died from untreated cardiac arrest.\u00a0 <\/span><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><span style=\"font-weight: 400;\">However, research has proven that grapefruit juice does nothing to <\/span><b>quinine<\/b><span style=\"font-weight: 400;\">. A study in New Zealand showed that healthy patients who ingested 600 mg of quinine sulfate and 200 mL of grapefruit juice did not suffer from any adverse side-effects (<\/span><a rel=\"nofollow noopener noreferrer\" target=\"_blank\" href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs002280050646\"><span style=\"font-weight: 400;\">P. C. Ho et. al<\/span><\/a><span style=\"font-weight: 400;\">). Additional research well into the 21st century continued to prove that quinine and grapefruit juice showed no adverse signs of drug-interactions (<\/span><a rel=\"nofollow noopener noreferrer\" target=\"_blank\" href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/grapefruit-juice\"><span style=\"font-weight: 400;\">Kane &amp; Lipsky 2000<\/span><\/a><span style=\"font-weight: 400;\">), if not any drug-interactions at all.\u00a0<\/span><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><span style=\"font-weight: 400;\">Meanwhile, studies with <\/span><b>quinidine<\/b> <span style=\"font-weight: 400;\">and grapefruit juice indicated severe side-effects. The <em>American Journal of Medicine<\/em> reported a case of a 31-year-old woman with QT syndrome dying of <\/span><i><span style=\"font-weight: 400;\">torsade de pointes<\/span><\/i><span style=\"font-weight: 400;\"> due to an excessive intake of grapefruit juice and tonic water with quinidine (<\/span><a rel=\"nofollow noopener noreferrer\" target=\"_blank\" href=\"https:\/\/www.amjmed.com\/article\/S0002-9343(03)00071-8\/fulltext\"><span style=\"font-weight: 400;\">Hermans et. al 2003<\/span><\/a><span style=\"font-weight: 400;\">). But that\u2019s not all. Even in healthy male volunteers, oral doses of quinidine and an intake of grapefruit juice led to a delayed response in heartbeats (<\/span><a rel=\"nofollow noopener noreferrer\" target=\"_blank\" href=\"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/j.1552-4604.1996.tb05034.x?sid=nlm%3Apubmed\"><span style=\"font-weight: 400;\">Min et. al 2006<\/span><\/a><span style=\"font-weight: 400;\">), emphasizing the risk of taking both substances.<\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"So_why_quinine_instead_of_quinidine_in_Moriarty_the_Patriot\"><\/span><span style=\"font-size: 18pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif; color: #333333;\">So, why quinine instead of quinidine in <i>Moriarty the Patriot<\/i>?\u00a0<\/span><\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><span style=\"font-weight: 400;\">It\u2019s possible that the Viscount\u2019s medication contained varying concentrations of quinidine and quinine. Chemical isolation processes to separate compounds were a relatively new concept in Victorian England, so refining quinine for public use may have been quite shoddy. At the same time, it must have also been a misnomer that quinidine <\/span><i><span style=\"font-weight: 400;\">is<\/span><\/i><span style=\"font-weight: 400;\"> quinine and they were falsely advertised under the same name for the sake of profit. Consumers don\u2019t care what the name of a drug is or its respective side-effects \u2014 as long as the drug has a similar name, it\u2019s considered <\/span><i><span style=\"font-weight: 400;\">the same<\/span><\/i><span style=\"font-weight: 400;\">. People will do anything for a wonder drug.\u00a0 <\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Was_it_realistic_for_Moriarty_to_know_about_grapefruit_juices_side-effect\"><\/span><span style=\"font-family: arial, helvetica, sans-serif; font-size: 18pt; color: #333333;\"><b>Was it realistic for Moriarty to know about grapefruit juice\u2019s side-effect?<\/b><\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-attachment-id=\"12419\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_aftermath\/\" data-orig-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Aftermath\" data-image-description=\"\" data-medium-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" width=\"696\" height=\"392\" alt=\"\" class=\"wp-image-12419 jetpack-lazy-image\" data-recalc-dims=\"1\" srcset=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?w=1440&amp;ssl=1 1440w\" data-lazy-sizes=\"(max-width: 696px) 100vw, 696px\" src=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=696%2C392&amp;is-pending-load=1#038;ssl=1\"\/><noscript><img decoding=\"async\" data-attachment-id=\"12419\" data-permalink=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/mtp_aftermath\/\" data-orig-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?fit=1440%2C810&amp;ssl=1\" data-orig-size=\"1440,810\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Moriarty the Patriot: Aftermath\" data-image-description=\"\" data-medium-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?fit=300%2C169&amp;ssl=1\" data-large-file=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?fit=696%2C392&amp;ssl=1\" loading=\"lazy\" width=\"696\" height=\"392\" src=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=696%2C392&amp;ssl=1\" alt=\"\" class=\"wp-image-12419\" srcset=\"https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=1024%2C576&amp;ssl=1 1024w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=300%2C169&amp;ssl=1 300w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=768%2C432&amp;ssl=1 768w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=696%2C392&amp;ssl=1 696w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=1068%2C601&amp;ssl=1 1068w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?resize=747%2C420&amp;ssl=1 747w, https:\/\/i2.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/MtP_Aftermath.png?w=1440&amp;ssl=1 1440w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" data-recalc-dims=\"1\"\/><\/noscript><\/figure>\n<p><span style=\"font-family: arial, helvetica, sans-serif; font-size: 12pt;\"><span style=\"font-weight: 400;\">There is absolutely no way that Moriarty would\u2019ve known that grapefruit juice had adverse side-effects on medicinal tonics and oral tablets. The first scientific experiment of grapefruit juice with medicine was recorded in the 1980s and later publicized by a <\/span><a rel=\"nofollow noopener noreferrer\" target=\"_blank\" href=\"https:\/\/www.nytimes.com\/2006\/03\/21\/health\/experts-reveal-the-secret-powers-of-grapefruit-juice.html\"><i><span style=\"font-weight: 400;\">New York Times<\/span><\/i><span style=\"font-weight: 400;\"> article<\/span><\/a><span style=\"font-weight: 400;\"> in 2006. However, to perpetuate the fact that Moriarty is a criminal genius and possesses academic knowledge far beyond the scope of Victorian England, creative licenses need to be taken to give him this insight and construct him as the <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/watch-movies-tv-seriess\/\" data-internallinksmanager029f6b8e52c=\"8\" title=\"Watch Movies &amp; TV Series\" target=\"_blank\" rel=\"noopener\">series<\/a>\u2019 most formidable character. I have to <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>laud the writers for introducing such a semi-realistic and fascinating method of assassination outside of the typical poison or toxic fumes.\u00a0<\/span><\/span>\n            <\/div>\n<p><script>\n                (function(d, s, id) {\n          var js, fjs = d.getElementsByTagName(s)[0];\n          if (d.getElementById(id)) return;\n          js = d.createElement(s); js.id = id;\n          js.src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js#xfbml=1&version=v2.9&appId=269442613521839\";\n          fjs.parentNode.insertBefore(js, fjs);\n        }(document, 'script', 'facebook-jssdk'));\n        <\/script><\/p>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more anime-manga articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/anime-manga\/\" target=\"_blank\" rel=\"noopener noreferrer\">anime-manga category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/anitrendz.net\/news\/2020\/11\/08\/moriarty-the-patriot-a-study-in-quinine\/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=moriarty-the-patriot-a-study-in-quinine\" target=\"_blank\" rel=\"noopener noreferrer\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;#Moriarty the Patriot: A Study in Quinine&#8221; This week on Moriarty the Patriot, the show\u2019s elusive criminal consultant orchestrates yet another grand homicide for the sake of the lower class. The gardener Burton and his wife Michelle have just lost their sick child because of the Viscount of Belfor\u2019s refusal to let him be treated&#8230;.<\/p>\n","protected":false},"author":1,"featured_media":108055,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/i0.wp.com\/anitrendz.net\/news\/wp-content\/uploads\/2020\/11\/Screen-Shot-2020-11-08-at-1.55.45-PM.png?fit=1440,810&ssl=1","fifu_image_alt":"","footnotes":""},"categories":[4],"tags":[],"class_list":["post-108054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anime-manga"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/108054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=108054"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/108054\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/108055"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=108054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=108054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=108054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}