{"id":152396,"date":"2021-01-12T08:00:01","date_gmt":"2021-01-12T05:00:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/study-finds-fragmented-sleep-patterns-can-predict-vulnerability-to-chronic-stress\/"},"modified":"2021-01-12T08:00:01","modified_gmt":"2021-01-12T05:00:01","slug":"study-finds-fragmented-sleep-patterns-can-predict-vulnerability-to-chronic-stress","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/study-finds-fragmented-sleep-patterns-can-predict-vulnerability-to-chronic-stress\/","title":{"rendered":"#Study finds fragmented sleep patterns can predict vulnerability to chronic stress"},"content":{"rendered":"

“#Study finds fragmented sleep patterns can predict vulnerability to chronic stress<\/strong>”<\/p>\n

\n
\n
\n
\"NYUAD
\n Research Associate Basma Radwan. Credit: NYU Abu Dhabi
\n <\/figcaption><\/figure>\n<\/div>\n<\/div>\n

New research from NYU Abu Dhabi’s Laboratory of Neural Systems and Behavior for the first time used an animal model to demonstrate how abnormal sleep architecture can be a predictor of stress vulnerability. These important findings have the potential to inform the development of sleep tests that can help identify who may be susceptible\u2014or resilient\u2014to future stress.\n <\/p>\n

In the study, Abnormal Sleep Signals Vulnerability to Chronic Social<\/a> Defeat Stress, which app<\/a>ears in the journal Frontiers in Neuroscience<\/a><\/i>, NYUAD Assistant Professor of Biology Dipesh Chaudhury and Research Associate Basma Radwan describe their development of a mouse model to detect how disruptions in Non-rapid Eye Movement (NREM) sleep result in increased vulnerability to future stress.<\/p>\n

The researchers assessed the sleep characteristics of both stress-susceptible and stress-resilient mice before and after experiencing chronic social defeat (CSD) stress. The social behavior of the mice post-stress was classified in two main phenotypes: those susceptible to stress that displayed social avoidance and those that were resilient to stress. Pre-CSD, mice susceptible to stress displayed increased fragmentation of Non-Rapid Eye Movement (NREM) sleep due to increased switching between NREM and wake and shorter average duration of NREM bouts, relative to mice resilient to stress. Their analysis showed that the pre-CSD sleep features from both phenotypes of mice allowed prediction of susceptibility to stress with more than 80 percent accuracy. Post-CSD, susceptible mice maintained high NREM fragmentation during the light and dark phase while resilient mice exhibited high NREM fragmentation only in the dark.<\/p>\n

The findings demonstrate that mice that become susceptible to CSD stress exhibit pre-existing abnormal sleep\/wake characteristics prior to stress exposure. In addition, subsequent exposure to stress further impairs sleep and the homeostatic response.<\/p>\n

“Our study is the first to provide an animal model to investigate the relationship between poor sleep continuity and vulnerability to chronic stress and depressive disorders,” said Chaudhury and Radwan. “This marker of vulnerability to stress opens up avenues for many possible future studies that could further explain the underlying molecular processes and neural circuitry that lead to mood disorders.”\n <\/p>\n\n

\n

Study shows that poor sleep can lead to depression in adolescents\n <\/p><\/div>\n

\n
\n More information:<\/strong>
\n Frontiers in Neuroscience<\/i> (2021). DOI: 10.3389\/fnins.2020.610655<\/a><\/p><\/div>\n
\n Provided by
\n New York University
\n
\n <\/svg><\/a><\/p><\/div>\n

<\/p>\n

\n

\n Citation<\/strong>:
\n Study finds fragmented sleep patterns can predict vulnerability to chronic stress (2021, January 12)
\n retrieved 12 January 2021
\n from https:\/\/medicalxpress.com\/news<\/a>\/2021-01-fragmented-patterns-vulnerability-chronic-stress.html<\/p>\n

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
\n part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n