{"id":178830,"date":"2021-02-15T20:21:36","date_gmt":"2021-02-15T17:21:36","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/scientists-use-ai-to-identify-existing-drugs-to-fight-covid-19\/"},"modified":"2021-02-15T20:21:36","modified_gmt":"2021-02-15T17:21:36","slug":"scientists-use-ai-to-identify-existing-drugs-to-fight-covid-19","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/scientists-use-ai-to-identify-existing-drugs-to-fight-covid-19\/","title":{"rendered":"#Scientists use AI to identify existing drugs to fight COVID-19"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a4155bc4f037\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a4155bc4f037\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/scientists-use-ai-to-identify-existing-drugs-to-fight-covid-19\/#A_causal_framework\" >A causal framework<\/a><\/li><\/ul><\/nav><\/div>\n<p>&#8220;<strong>#Scientists use AI to identify existing drugs to fight COVID-19<\/strong>&#8221;<br \/>\n<img decoding=\"async\" src=\"https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/02\/Untitled-design-2021-02-15T171220.358-796x417.png\" \/><\/p>\n<div>\n                                Scientists have used machine learning to find drugs already on the market that could also\u00a0fight COVID-19 in elderly patients.<\/p>\n<p>\u201cMaking new drugs takes forever,\u201d <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/eurekalert.org\/pub_releases\/2021-02\/miot-ama021221.php\">said<\/a> study co-author Caroline Uhler, a computational biologist at MIT. \u201cReally, the only expedient option is to repurpose existing drugs.\u201d<\/p>\n<p>The study team searched for potential treatments by analyzing changes to gene expressions in lung cells caused by both the disease and aging.<\/p>\n<p>Uhler said this combination could help medical experts find drugs to test on older people:<\/p>\n<blockquote><p><span>We need to look at aging together with SARS-CoV-2 \u2014 what are the genes at the intersection of these two pathways?<\/span><\/p>\n<\/blockquote>\n<p>The\u00a0<span style=\"color: #0a0a0a;\">researchers sought to answer this question through a three-step process<\/span><\/p>\n<p><em>[Read: How Polestar is using blockchain to increase transparency]<\/em><\/p>\n<p>First, they generated a list of candidate drugs using an autoencoder, a type of neural network that finds data representations in an unsupervised manner.<\/p>\n<p>The autoencoder analyzed two datasets of gene expression patterns to identify drugs\u00a0that <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>eared to counteract the virus.<\/p>\n<p>Next, the researchers narrowed down the list by\u00a0mapping the interactions of proteins involved in the aging and<span>\u00a0infection pathways. They then identified areas of overlap between the two maps.<\/span><\/p>\n<p>This pinpointed the gene expression network\u00a0a drug should target to fight COVID-19 in older patients.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"A_causal_framework\"><\/span>A causal framework<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Finally, the team used statistical algorithms to analyze causality in the network. This allowed them to identify the specific genes a drug should target to minimize the impact of infection.<\/p>\n<p>The system highlighted the RIPK1 gene as a promising target for the COVID-19 drugs. The researchers then found a list of approved drugs that act on RIPK1.<\/p>\n<p>Some of these have been approved for treating cancer, while others are already being tested on\u00a0COVID-19 patients.<\/p>\n<p>The researchers\u00a0note that rigorous in vitro experiments and clinical trials are still required to determine their efficacy. But they also envision extending their framework to other infections:<\/p>\n<blockquote><p><span>While we apply our computational platform in the context of SARS-CoV-2, our algorithms integrate data modalities that are available for many diseases, thereby making them broadly applicable.<\/span><\/p>\n<\/blockquote>\n<p>You can read the study paper <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41467-021-21056-z\">in <em>Nature Communications<\/em><\/a>.<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p class=\"c-post-pubDate\">\n                                    Published February 15, 2021 \u2014 17:21 UTC<\/p><\/div>\n<p><script data-src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js#xfbml=1&amp;appId=378011798897423&amp;version=v2.6\" id=\"socialSrcFacebook\" type=\"text\/template\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more like this article, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/technology\/\" target=\"_blank\" rel=\"noopener\">Technology category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/thenextweb.com\/neural\/2021\/02\/15\/ai-identifies-existing-drugs-repurpose-fight-covid-19-elderly\/\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;#Scientists use AI to identify existing drugs to fight COVID-19&#8221; Scientists have used machine learning to find drugs already on the market that could also\u00a0fight COVID-19 in elderly patients. \u201cMaking new drugs takes forever,\u201d said study co-author Caroline Uhler, a computational biologist at MIT. \u201cReally, the only expedient option is to repurpose existing drugs.\u201d The&#8230;<\/p>\n","protected":false},"author":1,"featured_media":178831,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/img-cdn.tnwcdn.com\/image\/neural?filter_last=1&fit=1280,640&url=https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/02\/Untitled-design-2021-02-15T171220.358.png&signature=dce4ee8cc691bc9ae1c26936d9930c0c","fifu_image_alt":"","footnotes":""},"categories":[18],"tags":[],"class_list":["post-178830","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/178830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=178830"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/178830\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/178831"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=178830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=178830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=178830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}