{"id":179938,"date":"2021-02-17T02:10:01","date_gmt":"2021-02-16T23:10:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/ici-need-not-be-withheld-in-those-with-autoimmune-disease\/"},"modified":"2021-02-17T02:10:01","modified_gmt":"2021-02-16T23:10:01","slug":"ici-need-not-be-withheld-in-those-with-autoimmune-disease","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/ici-need-not-be-withheld-in-those-with-autoimmune-disease\/","title":{"rendered":"#ICI need not be withheld in those with autoimmune disease"},"content":{"rendered":"

“#ICI need not be withheld in those with autoimmune disease<\/strong>”<\/p>\n

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\"ICI<\/figure>\n<\/div>\n<\/div>\n

(HealthDay)\u2014For patients with advanced melanoma, response to immune checkpoint inhibitors (ICIs) is similar for those with and without preexisting autoimmune disease (AID), according to a study published online Feb. 16 in the Annals of Internal Medicine.<\/i><\/p>\n

Monique K. van der Kooij, M.D., from Leiden University Medical Center in the Netherlands, and colleagues conducted a nationwide cohort study in the Netherlands to examine the safety and efficacy of ICIs in 4,367 patients with advanced melanoma with and without AID; 9.5 percent had AID.<\/p>\n

The researchers found that for patients with AID, the incidences of immune-related adverse events of grade 3 or higher were 30, 17, and 44 percent for those treated with anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4), anti-programmed cell death 1 (PD-1), and combination therapy, respectively; for patients without AID, the corresponding incidences were 30, 13, and 48 percent. Compared with patients without AID, those with AID more often discontinued anti-PD-1 treatment because of toxicity (17 versus 9 percent). Anti-PD-1-induced colitis occurred more often in patients with inflammatory bowel disease. Patients with versus without AID who were treated with anti-CTL-4, anti-PD-1, and combination therapy had similar objective response rates (10 versus 16 percent; 40 versus 44 percent; and 39 versus 43 percent, respectively). No difference was seen in survival for those with and without AID (media<\/a>n, 13 versus 14 months).<\/p>\n

“We encourage physicians not to withhold ICI in most common AIDs,” the authors write.\n <\/p>\n\n

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Immune checkpoint inhibitor therapy tied to cardiac event risk\n <\/p><\/div>\n

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Citation<\/strong>:
\n ICI need not be withheld in those with autoimmune disease (2021, February 16)
\n retrieved 16 February 2021
\n from https:\/\/medicalxpress.com\/news<\/a>\/2021-02-ici-withheld-autoimmune-disease.html<\/p>\n

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\n part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n