{"id":183798,"date":"2021-02-19T20:50:01","date_gmt":"2021-02-19T17:50:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/genetic-mutations-may-add-to-racial-disparity-in-child-b-all\/"},"modified":"2021-02-19T20:50:01","modified_gmt":"2021-02-19T17:50:01","slug":"genetic-mutations-may-add-to-racial-disparity-in-child-b-all","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/genetic-mutations-may-add-to-racial-disparity-in-child-b-all\/","title":{"rendered":"#Genetic mutations may add to racial disparity in child B-ALL"},"content":{"rendered":"

“#Genetic mutations may add to racial disparity in child B-ALL<\/strong>”<\/p>\n

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(HealthDay)\u2014Hispanic\/Latino (H\/L) children with B-cell acute lymphoblastic leukemia (B-ALL) have an increased incidence of IKZF1<\/i> deletion and IGH-CRLF2<\/i> translocation, according to a letter to the editor published online Feb. 2 in Leukemia<\/i>.<\/p>\n

Gordana Raca, M.D., Ph.D., from the Children’s Hospital Los Angeles, and colleagues analyzed clinical and molecular data from 239 pediatric B-ALL patients (164 self-reported as H\/L and 75 classified as non-H\/L) treated between March 2016 and July 2019 to examine the biological basis underlying the health disparity in H\/L children with B-ALL.<\/p>\n

The researchers found that compared with the non-H\/L population, the H\/L population had a significantly higher incidence of IKZF1<\/i> deletion (29 versus 15 percent). In the H\/L versus non-H\/L population, the concomitant IKZF1<\/i> deletion with CRLF2<\/i> translocation was strongly increased (12 versus 0 percent). A strong bias was seen in the association of IKZF1<\/i> deletion with specific CRLF2<\/i> translocation: In patients with IKZF1<\/i> deletion, the IGH-CRLF2<\/i> translocation was increased ninefold versus the P2RY8-CRLF2<\/i> fusion (18\/164 versus two\/164). In the H\/L versus the non-H\/L population, IKZF1<\/i> deletion concomitant with IGH-CRLF2<\/i> translocation was strongly increased (11 versus 0 percent).<\/p>\n

“These mutations offer an explanation for the poor prognosis and increased incidence of B-ALL in Hispanic and Latino children and offer us insight into this pediatric cancer health disparity,” a coauthor said in a statement. “Sequencing these genes in Hispanic and Latino children with B-ALL is essential to help pediatric oncologists determine a prognosis for these patients and develop app<\/a>ropriate treatment plans.”\n <\/p>\n\n

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Racial disparity seen in COVID-19 multisystem inflammatory syndrome\n <\/p><\/div>\n

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Citation<\/strong>:
\n Genetic mutations may add to racial disparity in child B-ALL (2021, February 19)
\n retrieved 19 February 2021
\n from https:\/\/medicalxpress.com\/news<\/a>\/2021-02-genetic-mutations-racial-disparity-child.html<\/p>\n

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