{"id":207324,"date":"2021-03-20T22:41:10","date_gmt":"2021-03-20T19:41:10","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/new-treatment-shows-promise-in-preventing-heart-failure-after-heart-attack\/"},"modified":"2021-03-20T22:41:10","modified_gmt":"2021-03-20T19:41:10","slug":"new-treatment-shows-promise-in-preventing-heart-failure-after-heart-attack","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/new-treatment-shows-promise-in-preventing-heart-failure-after-heart-attack\/","title":{"rendered":"#New treatment shows promise in preventing heart failure after heart attack"},"content":{"rendered":"

“#New treatment shows promise in preventing heart failure after heart attack<\/strong>”<\/p>\n

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A study in mice finds treatment with a molecule called MCB-613 repairs heart tissue after a severe heart attack, preventing damage that can lead to heart failure. The findings are being presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.<\/p>\n

“This is a remarkable discovery that may lead to effective and safe treatments to prevent the progression to heart failure after a heart attack,” said lead researcher Lisa K. Mullany, Ph.D., of Baylor College of Medicine in Houston.<\/p>\n

Heart failure after a heart attack is the leading cause of death in humans, and currently there are no definitive therapies other than heart transplantation.<\/p>\n

Researchers had previously found that MCB-613 stimulates proteins called steroid receptor coactivators (SRCs). These proteins are responsible for cellular changes and growth during both normal and abnormal tissue growth. After a heart attack, the damaged tissue scars. This results in tissue loss, as well as increased inflammation, scarring and decrease in heart function\u2014all hallmarks of heart failure caused by a heart attack.<\/p>\n

In the new study, the researchers were able to show that when mice were given MCB-613 within hours after a heart attack, the molecule decreased inflammation and scarring, and prevented the progressive decrease in heart function.<\/p>\n

“Our findings show us that we can directly modulate heart tissue repair to prevent heart failure,” Mullany said.\n <\/p>\n\n

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Treatment shows reduction in heart failure after myocardial infarction\n <\/p><\/div>\n

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\n The Endocrine Society
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Citation<\/strong>:
\n New treatment shows promise in preventing heart failure after heart attack (2021, March 20)
\n retrieved 20 March 2021
\n from https:\/\/medicalxpress.com\/news<\/a>\/2021-03-treatment-heart-failure.html<\/p>\n

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