{"id":215362,"date":"2021-03-30T23:12:35","date_gmt":"2021-03-30T20:12:35","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/effectiveness-of-anticoagulants-compared-for-valvular-a-fib\/"},"modified":"2021-03-30T23:12:35","modified_gmt":"2021-03-30T20:12:35","slug":"effectiveness-of-anticoagulants-compared-for-valvular-a-fib","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/effectiveness-of-anticoagulants-compared-for-valvular-a-fib\/","title":{"rendered":"#Effectiveness of anticoagulants compared for valvular A-fib"},"content":{"rendered":"

“#Effectiveness of anticoagulants compared for valvular A-fib<\/strong>”<\/p>\n

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\"Effectiveness<\/figure>\n<\/div>\n<\/div>\n

(HealthDay)\u2014For patients who are new to therapy for valvular atrial fibrillation (AF), direct oral anticoagulants (DOACs) as a class are effective and safe compared with warfarin, with some variability among individual DOACs, according to a study published online March 30 in the Annals of Internal Medicine<\/i>.\n <\/p>\n

Ghadeer K. Dawwas, Ph.D., from the University of Pennsylvania in Philadelphia, and colleagues examined the effectiveness and safety of DOACs compared to warfarin in a population-based cohort study involving 56,336 patients with valvular AF matched on propensity score. A composite outcome of ischemic stroke or systemic embolism was assessed as the primary effectiveness outcome, while the primary safety outcome was a composite of intracranial or gastrointestinal bleeding.<\/p>\n

The researchers found that use of DOACs versus warfarin was associated with a lower risk for ischemic stroke or systemic embolism and major bleeding events (hazard ratios [95 percent confidence intervals], 0.64 [0.59 to 0.70] and 0.67 [0.63 to 0.72], respectively). These results were consistent for apixaban (hazard ratios [95 percent confidence intervals], 0.54 [0.47 to 0.61] and 0.52 [0.47 to 0.57], respectively) and for rivaroxaban (hazard ratios [95 percent confidence intervals], 0.74 [0.64 to 0.86] and 0.87 [0.79 to 0.96], respectively); for dabigatran, the results were not significant for effectiveness (hazard ratio, 1.03; 95 percent confidence interval, 0.81 to 1.31) but were significant for the major bleeding outcome (hazard ratio, 0.81; 95 percent confidence interval, 0.68 to 0.97).<\/p>\n

“These real-world data suggest that patients with valvular AF who were new users of DOACs had a lower rate of ischemic stroke or systemic embolism and major bleeding than new users of warfarin,” the authors write. “These data should guide anticoagulant choices for patients with valvular AF.”<\/p>\n

Several authors disclosed financial ties to the pharmaceutical industry.\n <\/p>\n\n

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Rivaroxaban may be as effective as warfarin for bioprosthetic mitral valves, AF\n <\/p><\/div>\n

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\n retrieved 31 March 2021
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