{"id":220815,"date":"2021-04-06T23:20:34","date_gmt":"2021-04-06T20:20:34","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/why-can-stress-result-in-hair-loss-research-provides-clues\/"},"modified":"2021-04-06T23:20:34","modified_gmt":"2021-04-06T20:20:34","slug":"why-can-stress-result-in-hair-loss-research-provides-clues","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/why-can-stress-result-in-hair-loss-research-provides-clues\/","title":{"rendered":"#Why can stress result in hair loss? Research provides clues"},"content":{"rendered":"

“#Why can stress result in hair loss? Research provides clues<\/strong>”<\/p>\n

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It\u2019s well known that chronic stress can lead to\u00a0hair loss, but how exactly stress causes hair loss has been a mystery \u2014 until now. A new study conducted by researchers at Harvard University may provide a clue.\u00a0<\/p>\n

In a study recently published in the journal\u00a0Nature, <\/a>researchers determined that a stress hormone keeps hair follicle stem cells in an \u201cextended resting phase,\u201d meaning the growth of new hair is put on hold for a longer amount of time than normal.\u00a0<\/p>\n

First, it\u2019s important to understand the three stages of hair growth: growth, rest and degeneration. In the first state, hair follicle cells are activated and hair is continually produced, in the second, the hair stays in a state of rest but can still shed, and in the last stage \u2014 degeneration \u2014 hair falls out.\u00a0<\/p>\n

\u201cDuring the resting phase, the stem cells are quiescent and hairs shed more easily. Hair loss can occur if the hairs shed and the stem cells remain quiescent without regenerating new tissue,\u201d\u00a0explains an accompanying press release<\/a>\u00a0on the study\u2019s findings.\u00a0<\/p>\n

The researchers specifically looked at the adrenal glands, which produce a stress hormone called corticosterone, and the connection to hair loss in mice. (Corticosterone in mice is thought to be the equivalent of the stress hormone cortisol that is produced in humans.)\u00a0<\/p>\n

The researchers surgically removed adrenal glands from the mice in the study. Later, they found that the hair follicles in the mice with the removed adrenal glands had a shorter resting phase but entered the growth phase more often. When they administered corticosterone to the mice, their hair growth was slowed to normal.\u00a0<\/p>\n

Over nine weeks, the researchers also administered corticosterone to mice whose adrenal glands were still intact. They observed that these mice had elevated corticosterone levels as well as reduced hair growth, finding that their hair follicles stayed in a rest phase for a longer amount of time than normal.\u00a0<\/p>\n

\u201cThe real surprise came when we depleted stress hormones. Under normal conditions, hair follicle regeneration slows over time \u2013 the resting phase becomes longer as the animals age. But when we removed the stress hormones under unstressed normal conditions, the stem cells\u2019 resting phase became extremely short and the mice constantly entered the growth phase to regenerate new hair follicles and hairs throughout their life, even when they were old,\u201d said Ya-Chieh Hsu, the Alvin and Esta Star Associate Professor of Stem Cell and Regenerative Biology at Harvard and senior author of the study, to\u00a0Technology Networks.\u00a0<\/a><\/p>\n

The researchers shaved the mice whose adrenal glands were removed. Nineteen days later, they had a fully regrown coat, while the mice who did not have their adrenal glands removed and were also shaved were still mostly bald.\u00a0<\/p>\n

\u201cSo even the baseline level of stress hormone that\u2019s normally circulating in the body is an important regulator of the resting phase. Stress essentially just elevates this preexisting \u2018adrenal gland\u2013hair follicle axis,\u2019 making it even more difficult for hair follicle stem cells to enter the growth phase to regenerate new hair follicles,\u201d Hsu explained in the accompanying press release on the study\u2019s findings.\u00a0<\/p>\n

Once the link between the stress hormone and hair follicle stem cell activity was noted, the researchers then explored the biological mechanism behind the connection.<\/p>\n

\u201cWe first asked whether the stress hormone was regulating the stem cells directly and checked by taking out the receptor for corticosterone, but this turned out to be wrong. Instead, we found that the stress hormone actually acts on a cluster of dermal cells underneath the hair follicle, known as the dermal papilla,\u201d Sekyu Choi, another study leader, said in a statement.\u00a0<\/p>\n

\u201cDermal papilla is known to be critical for activating hair follicle stem cells, but none of the previously identified factors secreted from dermal papilla changed when stress hormone levels were altered. Rather, the stress hormone prevented dermal papilla cells from secreting Gas6, a molecule that the researchers showed can activate the hair follicle stem cells,\u201d reads the release.\u00a0<\/p>\n

\"Woman
Once the link between the stress hormone and hair follicle stem cell activity was noted, the researchers then explored the biological mechanism behind the connection.<\/figcaption>
Getty Images\/iStockphoto<\/span><\/figcaption><\/figure>\n

Though more research is needed, the study authors are hopeful that certain gene therapies could be possibly used in the future to combat hair loss in humans.\u00a0<\/p>\n

\u201cUnder both normal and stress conditions, adding Gas6 was sufficient to activate hair follicle stem cells that were in the resting phase and to promote hair growth,\u201d Choi said. \u201cIn the future, the Gas6 pathway could be exploited for its potential in activating stem cells to promote hair growth. It will also be very interesting to explore if other stress-related tissue changes are related to the stress hormone\u2019s impact on regulating Gas6.\u201d<\/p>\n

\u201cWhen looking for factors that control stem cell behaviors, normally we would look locally in the skin. While there are important local factors, our findings suggest that the major switch for hair follicle stem cell activity is actually far away in the adrenal gland and it works by changing the threshold required for stem cell activation,\u201d Hsu added.\u00a0<\/p>\n

\u201cYou can have systemic control of stem cell behavior located in a different organ that plays a really important role, and we are learning more and more examples of these \u2018cross-organ interactions.\u2019 Tissue biology is interconnected with body physiology. We still have so much to learn in this area, but we are constantly reminded by our findings that in order to understand stem cells in the skin, we often need to think beyond the skin.\u201d<\/p><\/div>\n

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“#Why can stress result in hair loss? Research provides clues” It\u2019s well known that chronic stress can lead to\u00a0hair loss, but how exactly stress causes hair loss has been a mystery \u2014 until now. A new study conducted by researchers at Harvard University may provide a clue.\u00a0 In a study recently published in the journal\u00a0Nature,…<\/p>\n","protected":false},"author":1,"featured_media":220816,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2021\/04\/hair-loss-stress-01.jpg?quality=90&strip=all&w=1200","fifu_image_alt":"","footnotes":""},"categories":[70897],"tags":[100971,70538,5050,72685,9724],"class_list":["post-220815","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-4-6-21","tag-hair","tag-scientists","tag-stress","tag-study-says"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/220815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=220815"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/220815\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/220816"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=220815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=220815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=220815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}