{"id":22739,"date":"2020-07-07T23:40:00","date_gmt":"2020-07-07T20:40:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/bad-e-coli-we-know-but-good-e-coli\/"},"modified":"2020-07-07T23:40:00","modified_gmt":"2020-07-07T20:40:00","slug":"bad-e-coli-we-know-but-good-e-coli","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/bad-e-coli-we-know-but-good-e-coli\/","title":{"rendered":"#Bad E. coli we know, but good E. coli?"},"content":{"rendered":"

“#Bad E. coli we know, but good E. coli?<\/strong>”<\/p>\n

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\"Bad<\/img>
\n Alison Weiss, PhD, and Suman Pradhan, PhD, shown in a laboratory at the University of Cincinnati. Credit: Colleen Kelley\/University of Cincinnati Creative Brand
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Typically, there aren’t a lot of positive thoughts when E. coli<\/i>, general<\/a>ly found in animal and human intestines, is mentioned. It’s been blamed for closing beaches and swimming pools and shuttering restaurants because of contamination in salad bars, meats or other food items.<\/p>\n

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But for more than a century, one strain of the bacteria, E. coli<\/i> Nissle 1917, has been used as a probiotic and therapeutic agent. Currently, it is used in some countries to treat intestinal inflammation.<\/p>\n

Now researchers at the University of Cincinnati College of Medicine say E. coli<\/i> Nissle may also protect human cells against other more pathogenic strains of E. coli<\/i> such as E. coli<\/i> 0157:H7, which is commonly associated with contaminated hamburger meat.
\nAlison Weiss, Ph.D., professor, and Suman Pradhan, Ph.D., research associate, both in in the UC Department of Molecular Genetics, Biochemistry and Microbiology, used stem cell-derived human intestinal organoid tissues to evaluate the safety of Nissle and its ability to protect from pathogenic E. coli<\/i> bacteria 0157:H7.
\nThey found that human intestinal tissues (HIO) were not harmed by the Nissle bacteria introduced into human intestinal organoids while pathogenic E. coli<\/i> bacteria destroyed the epithelial layer of the HIO. More importantly, Nissle protected the HIOs when added prior to pathogenic E. coli<\/i> bacterial infection.
\nThe study’s findings are available online in mBio<\/i>, the scholarly journal of the American Society for Microbiology.
\n“Nissle did not kill pathogenic E. coli<\/i>, but rather ramps up your intestinal responses and prepares you for possible pathogens attacking the intestine,” explains Weiss, corresponding author of the study. “We don’t know how it does this, but our study confirms its effectiveness in human cells. Our hope is to figure out how this is happ<\/a>ening.”
\n“There are all sorts of flavors of E. coli<\/i>,” says Weiss. “They gather genes from all over the place and channel a whole bunch of other pathogens. There are E.coli which can also cause urinary tract infections. What is special is that bad E. coli<\/i> have a chunk of extra genes that allow them to cause problems. The good E. coli<\/i> are strip<\/a>ped down of these genes and they don’t have the capacity to do bad things.”
\nWeiss says they hope to learn more about the abilities of Nissle in order to develop a treatment of E. coli<\/i> infections that often result from the production of Shiga toxins. The Centers for Disease Control and Prevention estimates that 265,000 such infections occur annually causing stomach cramps, diarrhea and vomiting. Cases can be mild to severe and affect people of all ages, though the illness can be particularly hard on smaller children, who are more likely to die from an infection, says Weiss. Moreover, antibiotic treatment of children with E. coli<\/i> 0157:H7 infection increases the risk of hemolytic-uremic syndrome.
\n“Right now there is no cure for an E. coli<\/i> infection,” says Weiss. “We can give individuals fluids, but it can be really deadly and it would be really nice for us to figure out how to cure it.”
\n“E. coli<\/i> is carried asymptotically by all sorts of animals and released into their fecal matter and then leading to possible contamination if it comes into contact with food items or is ingested,” says Weiss. “It is difficult though still possible to screen meat for E. coli<\/i>. The best possible protection is to cook meat properly before consuming it. E. coli<\/i> is also found in raw vegetables such as lettuce and it can be difficult to detect and remove.”<\/p>\n

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More information:<\/strong>
\n Suman Pradhan et al. Probiotic Properties of Escherichia coli Nissle in Human Intestinal Organoids, mBio<\/i> (2020). DOI: 10.1128\/mBio.01470-20<\/p>\n

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Journal information:<\/strong>
\n mBio<\/cite><\/p>\n


\n <\/use><\/svg><\/a> <\/p><\/div>\n<\/p><\/div>\n

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Citation<\/strong>:
\n Bad E. coli we know, but good E. coli? (2020, July 7)
\n retrieved 7 July 2020
\n from https:\/\/phys.org\/news<\/a>\/2020-07-bad-coli-good.html<\/p>\n

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
\n part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n

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“#Bad E. coli we know, but good E. coli?” Alison Weiss, PhD, and Suman Pradhan, PhD, shown in a laboratory at the University of Cincinnati. Credit: Colleen Kelley\/University of Cincinnati Creative Brand Typically, there aren’t a lot of positive thoughts when E. coli, generally found in animal and human intestines, is mentioned. It’s been blamed…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[34314,34315,10670],"class_list":["post-22739","post","type-post","status-publish","format-standard","hentry","category-sciencee","tag-bad-e-coli-we-know","tag-but-good-e-coli","tag-cell-microbiology"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/22739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=22739"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/22739\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=22739"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=22739"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=22739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}