{"id":229840,"date":"2021-04-18T18:30:33","date_gmt":"2021-04-18T15:30:33","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/what-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data\/"},"modified":"2021-04-18T18:30:33","modified_gmt":"2021-04-18T15:30:33","slug":"what-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/what-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data\/","title":{"rendered":"#What we can learn from sequencing 1 million human genomes with big data"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a295a6145234\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a295a6145234\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/what-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data\/#Understanding_genetic_diversity\" >Understanding genetic diversity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/what-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data\/#1000000_genomes\" >1,000,000 genomes<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/what-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data\/#The_dark_matter_of_the_human_genome\" >The dark matter of the human genome<\/a><\/li><\/ul><\/nav><\/div>\n<p>&#8220;<strong>#What we can learn from sequencing 1 million human genomes with big data<\/strong>&#8221;<\/p>\n<div>The first draft of the human genome was <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.washingtonpost.com\/archive\/politics\/2000\/06\/27\/teams-finish-mapping-human-dna\/3af9bfcf-e7b6-4ac1-bcdb-f4fc117c19bd\/\">published 20 years ago<\/a> in <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.genome.gov\/25520483\/online-education-kit-2001-first-draft-of-the-human-genome-sequence-released\">2001<\/a>, took nearly three years and cost <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.genome.gov\/about-genomics\/fact-sheets\/Sequencing-Human-Genome-cost\">between US$500 million and $1 billion<\/a>. The <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.genome.gov\/human-genome-project\">Human Genome Project<\/a> has allowed scientists to read, almost end to end, the 3 billion pairs of DNA bases \u2013 or \u201cletters\u201d \u2013 that biologically define a human being.<\/p>\n<p>That project has allowed a new generation of <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/scholar.google.com\/citations?user=Yy8gde8AAAAJ&amp;hl=en&amp;oi=ao\">researchers like me<\/a>, currently a postdoctoral fellow at the National Cancer Institute, to identify <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41586-020-2099-x\">novel targets for cancer treatments<\/a>, engineer <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41590-019-0416-z\">mice with human immune systems<\/a> and even build a <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/genome.ucsc.edu\/cgi-bin\/hgTracks?db=hg38&amp;lastVirtModeType=default&amp;lastVirtModeExtraState=&amp;virtModeType=default&amp;virtMode=0&amp;nonVirtPosition=&amp;position=chr14%3A95086244%2D95158010&amp;hgsid=1066518897_QJL7hsBNGEhTnw6DgqcZaMG4YFB2\">webpage where anyone can navigate the entire human genome<\/a> with the same ease with which you use Google Maps.<\/p>\n<p>The first complete genome was generated from a handful of anonymous donors to try to produce a reference genome that represented more than just one single individual. But this fell far short of encompassing <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/nature18964\">the wide diversity of human populations in the world<\/a>. No two people are the same and no two genomes are the same, either. If researchers wanted to understand humanity in all its diversity, it would take sequencing thousands or millions of complete genomes. Now, a project like that is underway.<\/p>\n<figure class=\"post-image post-mediaBleed aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1347124 lazyreplaced\" src=\"https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/human-2944064_1920.jpg\" alt=\"There is a huge amount of genetic variation between people around the globe.\" width=\"1640\" height=\"860\" sizes=\"auto, (max-width: 1640px) 100vw, 1640px\" srcset=\"https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/human-2944064_1920.jpg 1640w, https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/human-2944064_1920-280x147.jpg 280w, https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/human-2944064_1920-515x270.jpg 515w, https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/human-2944064_1920-257x135.jpg 257w, https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/human-2944064_1920-796x417.jpg 796w, https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/human-2944064_1920-1592x835.jpg 1592w\"\/><figcaption>Credit: <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/pixabay.com\/photos\/human-observer-exhibition-2944064\/\">Gerd Altmann from Pixabay <\/a><\/figcaption><figcaption><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/thenextweb.com\/news\/#\" data-url=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Feditorial.thenextweb.com%2Fscience%2F2021%2F04%2F18%2Fwhat-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data-syndication%2F&amp;via=thenextweb&amp;related=thenextweb&amp;text=Check out this picture on: There is a huge amount of genetic variation between people around the globe.\" data-title=\"Share There is a huge amount of genetic variation between people around the globe. on Twitter\" data-width=\"685\" data-height=\"500\" class=\"post-image-share popitup\" title=\"Share There is a huge amount of genetic variation between people around the globe. on Twitter\"><i class=\"icon icon--inline icon--twitter--dark\"\/><\/a>There is a huge amount of genetic variation between people around the globe.<span style=\"font-size: 16px;\"\/><\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"Understanding_genetic_diversity\"><\/span>Understanding genetic diversity<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The wealth of genetic variation among people is what makes each person unique. But genetic changes also cause many disorders and make some groups of people more susceptible to certain diseases than others.<\/p>\n<p>Around the time of the Human Genome Project, researchers were also sequencing the complete genomes of organisms such as <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/nature01262\">mice<\/a>, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1126\/science.287.5461.2185\">fruit flies<\/a>, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1126\/science.274.5287.546\">yeasts<\/a> and <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/35048692\">some plants<\/a>. The huge effort made to generate these first genomes led to a revolution in the <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> required to read genomes. Thanks to these advances, instead of taking years and costing hundreds of millions of dollars to sequence a whole human genome, it now takes <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.genome.gov\/about-genomics\/fact-sheets\/Sequencing-Human-Genome-cost\">a few days and costs merely a thousand dollars<\/a>. Genome sequencing is very different from genotyping services like 23 and Me or Ancestry, which look at only a tiny fraction of locations in a person\u2019s genome.<\/p>\n<p>Advances in technology have allowed scientists to sequence the complete genomes of thousands of individuals from around the world. Initiatives such as the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/gnomad.broadinstitute.org\/\">Genome Aggregation Consortia<\/a> are currently making efforts to collect and organize this scattered data. So far, that group has been able to gather nearly <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41586-020-03174-8\">150,000 genomes<\/a> that show an incredible amount of human genetic diversity. Within that set, researchers have found more than 241 million differences in people\u2019s genomes, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/nature19057\">with an average of one variant for every eight base pairs<\/a>.<\/p>\n<p>Most of these variations are very rare and will have no effect on a person. However, hidden among them are variants with important physiological and medical consequences. For example, certain variants in the BRCA1 gene predispose some groups of woman, like Ashkenazi Jews, to <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41586-018-0461-z\">ovarian and breast cancer<\/a>. Other variants in that gene lead some <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41467-018-06616-0\">Nigerian women to experience higher-than-normal mortality<\/a> from breast cancer.<\/p>\n<p>The best way researchers can identify these types of population-level variants is through <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ebi.ac.uk\/gwas\/\">genomewide association studies<\/a> that compare the genomes of large groups of people with a control group. But diseases are complicated. An individual\u2019s lifestyle, symptoms and time of onset can vary greatly, and the effect of genetics on many diseases is hard to distinguish. The predictive power of current genomic research is too low to tease out many of these effects because <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41588-018-0313-7\">there isn\u2019t enough genomic data<\/a>.<\/p>\n<p>Understanding the genetics of complex diseases, especially those related to the genetic differences among ethnic groups, is essentially a big data problem. And researchers need more data.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"1000000_genomes\"><\/span>1,000,000 genomes<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<figure class=\"align-right zoomable\">\n<p><figure class=\"post-image post-mediaBleed aligncenter\"><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=237&amp;fit=clip\" sizes=\"auto, (min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px\" alt=\"The double helix DNA structure.\" width=\"600\" height=\"1038\" class=\"lazyreplaced\" srcset=\"https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=1038&amp;fit=crop&amp;dpr=1 600w, https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=1038&amp;fit=crop&amp;dpr=2 1200w, https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=1038&amp;fit=crop&amp;dpr=3 1800w, https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=1304&amp;fit=crop&amp;dpr=1 754w, https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=1304&amp;fit=crop&amp;dpr=2 1508w, https:\/\/images.theconversation.com\/files\/395116\/original\/file-20210414-16-rrcqz1.gif?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=1304&amp;fit=crop&amp;dpr=3 2262w\"\/><\/a><figcaption><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/thenextweb.com\/news\/#\" data-url=\"https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Feditorial.thenextweb.com%2Fscience%2F2021%2F04%2F18%2Fwhat-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data-syndication%2F&amp;via=thenextweb&amp;related=thenextweb&amp;text=Check out this picture on: The link between genetics and disease is nuanced, but the more genomes you can study, the easier it is to find those links. Image via brian0918\/Wikimedia Commons\" data-title=\"Share The link between genetics and disease is nuanced, but the more genomes you can study, the easier it is to find those links. Image via brian0918\/Wikimedia Commons on Twitter\" data-width=\"685\" data-height=\"500\" class=\"post-image-share popitup\" title=\"Share The link between genetics and disease is nuanced, but the more genomes you can study, the easier it is to find those links. Image via brian0918\/Wikimedia Commons on Twitter\"><i class=\"icon icon--inline icon--twitter--dark\"\/><\/a>The link between genetics and disease is nuanced, but the more genomes you can study, the easier it is to find those links. Image via brian0918\/Wiki<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a> Commons<\/figcaption><\/figure>\n<\/p>\n<\/figure>\n<p>To address the need for more data, the National Institutes of Health has started a program called <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/allofus.nih.gov\/\">All of Us<\/a>. The project aims to collect genetic information, medical records and health habits from surveys and wearables of more than a million people in the U.S. over the course of 10 years. It also has a goal of gathering more data from underrepresented minority groups to facilitate the study of health disparities. The <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.fda.gov\/regulatory-information\/selected-amendments-fdc-act\/21st-century-cures-act\">All of Us project<\/a> opened to public enrollment in 2018, and more than 270,000 people have contributed samples since. The project is continuing to recruit participants from all 50 states. Participating in this effort are many academic laboratories and private companies.<\/p>\n<p>This effort could benefit scientists from a wide range of fields. For instance, a neuroscientist could look for genetic variations associated with depression while taking into account exercise levels. An oncologist could search for variants that correlate with reduced risk of skin cancer while exploring the influence of ethnic background.<\/p>\n<p>A million genomes and the accompanying health and lifestyle information will provide an extraordinary wealth of data that should allow researchers to discover the effects of genetic variation on diseases, not only for individuals, but also within different groups of people.<\/p>\n<p>[<em>Understand new developments in <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a>, health and technology, each week.<\/em><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/us\/newsletters\/science-editors-picks-71\/?utm_source=TCUS&amp;utm_medium=inline-link&amp;utm_campaign=newsletter-text&amp;utm_content=science-understand\">Subscribe to The Conversation\u2019s science newsletter<\/a>.]<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_dark_matter_of_the_human_genome\"><\/span>The dark matter of the human genome<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Another benefit of this project is that it will allow scientists to learn about parts of the human genome that are currently very hard to study. Most genetic research has been on the parts of the genome that encode for proteins. However, these represent only <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/dx.doi.org\/10.1038%2Fnrd.2018.93\">1.5% of the human genome<\/a>.<\/p>\n<p>My research focuses on RNA \u2013 a molecule that turns the messages encoded in a person\u2019s DNA into proteins. However, RNAs that come from the 98.5% of the human genome that doesn\u2019t make proteins have a myriad of functions by themselves. Some of these noncoding RNAs are involved in processes such as <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/nature08975\">how cancer spreads<\/a>, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1242\/dev.146613\">embryonic development<\/a> or <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/35047580\">controlling the X chromosome in females<\/a>. In particular, I study how genetic variations can influence the intricate folding that allows noncoding RNAs to do their jobs. Since the All of Us project includes all coding and noncoding parts of the genome, it is going to be by far the largest dataset relevant to my work and will hopefully shed light on these mysterious RNAs.<\/p>\n<p>The first human genome sparked 20 years of incredible scientific progress. I think it is almost certain that a huge dataset of genomic variations will unlock clues about complex diseases. Thanks to large-scale population studies and big-data projects such as All of Us, researchers are paving the way to answering, in the next decade, how our individual genetics shape our health.<!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https:\/\/theconversation.com\/republishing-guidelines --><\/p>\n<p><em>This article by\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/profiles\/xavier-bofill-de-ros-1207107\">Xavier Bofill De Ros<\/a>, Research Fellow in RNA biology, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/institutions\/national-institutes-of-health-1742\">National Institutes of Health<\/a>,\u00a0is republished from <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\">The Conversation<\/a> under a Creative Commons license. Read the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/scientists-are-on-a-path-to-sequencing-1-million-human-genomes-and-use-big-data-to-unlock-genetic-secrets-157210\">original article<\/a>.<\/em><\/p>\n<\/div>\n<p><script async src=\"\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><script data-src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js#xfbml=1&amp;appId=378011798897423&amp;version=v2.6\" id=\"socialSrcFacebook\" type=\"text\/template\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more like this article, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/technology\/\" target=\"_blank\" rel=\"noopener\">Technology category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/thenextweb.com\/news\/what-we-can-learn-from-sequencing-1-million-human-genomes-with-big-data-syndication\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;#What we can learn from sequencing 1 million human genomes with big data&#8221; The first draft of the human genome was published 20 years ago in 2001, took nearly three years and cost between US$500 million and $1 billion. The Human Genome Project has allowed scientists to read, almost end to end, the 3 billion&#8230;<\/p>\n","protected":false},"author":1,"featured_media":229841,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/img-cdn.tnwcdn.com\/image\/tnw?filter_last=1&fit=1280,640&url=https:\/\/cdn0.tnwcdn.com\/wp-content\/blogs.dir\/1\/files\/2021\/04\/Human-Chromosome-Colours.jpg&signature=508dd4ec7e10a429c027eb3d936b0e14","fifu_image_alt":"","footnotes":""},"categories":[18],"tags":[],"class_list":["post-229840","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/229840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=229840"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/229840\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/229841"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=229840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=229840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=229840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}