{"id":248632,"date":"2021-05-13T13:33:00","date_gmt":"2021-05-13T10:33:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/mixing-pfizer-and-astrazeneca-covid-19-vaccines-increases-mild-side-effects-but-is-safe-study-shows\/"},"modified":"2021-05-13T13:33:00","modified_gmt":"2021-05-13T10:33:00","slug":"mixing-pfizer-and-astrazeneca-covid-19-vaccines-increases-mild-side-effects-but-is-safe-study-shows","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/mixing-pfizer-and-astrazeneca-covid-19-vaccines-increases-mild-side-effects-but-is-safe-study-shows\/","title":{"rendered":"#\n  Mixing Pfizer and AstraZeneca COVID-19 vaccines increases mild side effects but is safe, study shows"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3c3306183f0\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3c3306183f0\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/mixing-pfizer-and-astrazeneca-covid-19-vaccines-increases-mild-side-effects-but-is-safe-study-shows\/#Adverse_reactions_were_short-lived_with_no_other_safety_concerns_researchers_say\" >Adverse reactions were short-lived, with no other safety concerns, researchers say<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/mixing-pfizer-and-astrazeneca-covid-19-vaccines-increases-mild-side-effects-but-is-safe-study-shows\/#Lina_Saigol\" >Lina Saigol<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<p>&#8220;<strong>#<br \/>\n  Mixing Pfizer and AstraZeneca COVID-19 vaccines increases mild side effects but is safe, study shows<br \/>\n<\/strong>&#8221;<\/p>\n<h2 class=\"article__subhead\" itemprop=\"alternativeHeadline\"><span class=\"ez-toc-section\" id=\"Adverse_reactions_were_short-lived_with_no_other_safety_concerns_researchers_say\"><\/span>\n  Adverse reactions were short-lived, with no other safety concerns, researchers say<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><\/p>\n<div class=\"column column--full article__content\">\n<div class=\"article__side\">\n<div class=\"container--sticky not-active\">\n<div id=\"cx-next\">\n              <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<div id=\"js-article__body\" class=\"article__body article-wrap at16-col16 barrons-article-wrap\" itemprop=\"articleBody\" data-sbid=\"WP-MKTW-0000267899\">\n<div class=\"barrons-article-ad-wrapper\">\n<div data-track=\"barrons-article-ad-wrap\" class=\"barrons-article-ad sticky_item\">\n<div class=\"barrons-main-article-ad-target sticky_target body_ad\" aria-hidden=\"true\"><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>       Mixing doses of COVID-19 vaccines increases the risk of mild to moderate side effects when compared with administering two shots of the same vaccine, but is safe, according to data from a key U.K. trial.<\/p>\n<p> The\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/comcovstudy.org.uk\/about-com-cov1\" class=\"icon none\">Com-Cov<\/a> study, led by the University of Oxford, was launched in February to compare the effect of administering a first dose of the vaccine developed by Oxford and drug company AstraZeneca<br \/>\n        AZN,<br \/>\n        <bg-quote field=\"percentchange\" format=\"0,000.00%\" channel=\"\/zigman2\/quotes\/200304487\/composite\" class=\"positive\">+0.74%<\/bg-quote><\/p>\n<p>        AZN,<br \/>\n        <bg-quote field=\"percentchange\" format=\"0,000.00%\" channel=\"\/zigman2\/quotes\/203048482\/delayed\" class=\"negative\">-0.71%<\/bg-quote><br \/>\n       followed a few weeks later by the vaccine made jointly by drug company Pfizer<br \/>\n        PFE,<br \/>\n        <bg-quote field=\"percentchange\" format=\"0,000.00%\" channel=\"\/zigman2\/quotes\/202877789\/composite\" class=\"positive\">+0.86%<\/bg-quote><br \/>\n      \u00a0and its partner BioNTech<br \/>\n        BNTX,<br \/>\n        <bg-quote field=\"percentchange\" format=\"0,000.00%\" channel=\"\/zigman2\/quotes\/214419716\/composite\" class=\"negative\">-6.00%<\/bg-quote><span>,<\/span><br \/>\n       and vice versa.<\/p>\n<div class=\"paywall\">\n       The trial involved 830 volunteers aged over 50, who received four different combinations of the AstraZeneca and Pfizer\u2013BioNTech shots. The first full results are expected to be published in June. <\/p>\n<p>Preliminary results, published on Wednesday in a peer-reviewed letter in medical journal <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)01115-6\/fulltext\" class=\"icon none\">The Lancet<\/a>, showed that participants receiving a mixed schedule of the vaccines incurred more frequent reactions, such as chills, fatigue, headache, and muscle pain, than those on standard nonmixed schedules.<\/p>\n<p>For example, 34% of people who received an AstraZeneca shot followed by a Pfizer\u2013BioNTech one felt feverish, compared with 10% of those who received two doses of the AstraZeneca vaccine.<\/p>\n<p>However, any adverse reactions were short-lived, with no other safety concerns, the researchers wrote.<\/p>\n<p><strong>Read:<\/strong> EU won\u2019t renew AstraZeneca COVID-19 vaccine; Pfizer shot will take precedence<\/p>\n<p>The results will be closely watched by several countries that are considering mixing COVID-19 vaccines in immunization campaigns, either because of safety concerns about the AstraZeneca shot following reports of blood clots in some recipients, or to help shore up supplies. <\/p>\n<p>The <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/nationalpost.com\/news\/canada\/ontario-likely-to-mix-1st-and-2nd-vaccine-doses-amid-lack-of-astrazeneca-supply\" class=\"icon none\">Canadian provinces of Ontario and Quebec<\/a> have both said it is likely that recipients of the AstraZeneca vaccine may receive a different shot for their second dose. Meanwhile, the U.K., France and Germany are all offering a second dose of a different vaccine to younger people who received a first dose of the AstraZeneca shot, following concerns over rare blood clots in some recipients of the shot.<\/p>\n<p><strong>Read: <\/strong>Under-40s to be offered alternative COVID-19 vaccines to AstraZeneca\u2019s<\/p>\n<div id=\"cx-membership-tile\"><\/div>\n<p>Matthew Snape, associate professor in pediatrics and vaccinology at the University of Oxford, and chief investigator on the Com-Cov trial, said: \u201cWhilst this is a secondary part of what we are trying to explore through these studies, it is important that we inform people about these data, especially as these mixed-doses schedules are being considered in several countries.<\/p>\n<p>\u201cThe results from this study suggest that mixed-dose schedules could result in an increase in work absences the day after immunization, and this is important to consider when planning immunization of healthcare workers.<\/p>\n<p>\u201cImportantly, there are no safety concerns or signals, and this does not tell us if the immune response will be affected,\u201d Snape said.<\/p>\n<p>The researchers also cautioned that the side effects of mixing vaccines could be worse for younger people, who tend to have more active immune responses than participants in the study who were aged 50 and above.<\/p>\n<p><strong>Read: <\/strong>Moderna and Novavax added to \u2018mix and match\u2019 COVID-19 vaccine trial<\/p>\n<p>In April, the trial was expanded to include the COVID-19 vaccines made by biotech Moderna<br \/>\n        MRNA,<br \/>\n        <bg-quote field=\"percentchange\" format=\"0,000.00%\" channel=\"\/zigman2\/quotes\/205619834\/composite\" class=\"negative\">-3.97%<\/bg-quote><br \/>\n       and vaccine developer Novavax<br \/>\n        NVAX,<br \/>\n        <bg-quote field=\"percentchange\" format=\"0,000.00%\" channel=\"\/zigman2\/quotes\/202614340\/composite\" class=\"negative\">-7.50%<\/bg-quote><span>.<\/span><br \/>\n       The new study \u2014 called <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/comcovstudy.org.uk\/about-com-cov2\" class=\"icon none\">Com-Cov 2<\/a>, seeks to recruit adults aged over 50 who have received their first vaccination in the past eight to 12 weeks, bringing the total number of participants in the trial to 1,050.<\/p>\n<p>Volunteers would have received either the AstraZeneca or the Pfizer\u2013BioNTech vaccine, and then be randomly allocated to receive either the same vaccine for their second dose or a dose of the vaccines produced by Moderna or Novavax. The trial is designed as a so-called \u2018noninferiority\u2019 study, which means its intent is to demonstrate that mixing isn\u2019t substantially worse than not mixing.<\/p><\/div>\n<\/div><\/div>\n<p><\/p>\n<div class=\"byline article__byline\">\n<p>      <span>By<\/span><\/p>\n<div class=\"author  hasMenu\" data-scrim='{\"type\":\"author\",\"header\":\"Lina Saigol\",\"subhead\":\"The Wall Street Journal\",\"list\":[]}' itemscope itemprop=\"author\" itemtype=\"http:\/\/schema.org\/Person\">\n<h4 itemprop=\"name\"><span class=\"ez-toc-section\" id=\"Lina_Saigol\"><\/span>Lina Saigol<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<\/p><\/div>\n<\/div>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">News<\/a> articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/news\/\" target=\"_blank\" rel=\"noopener\">News category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"http:\/\/www.marketwatch.com\/news\/story.asp?guid=%7B20C05575-04D4-B545-7416-7B51F20448A2%7D&#038;siteid=rss&#038;rss=1\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;# Mixing Pfizer and AstraZeneca COVID-19 vaccines increases mild side effects but is safe, study shows &#8221; Adverse reactions were short-lived, with no other safety concerns, researchers say Mixing doses of COVID-19 vaccines increases the risk of mild to moderate side effects when compared with administering two shots of the same vaccine, but is safe,&#8230;<\/p>\n","protected":false},"author":1,"featured_media":248633,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[70897],"tags":[],"class_list":["post-248632","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/248632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=248632"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/248632\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/248633"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=248632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=248632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=248632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}