{"id":249673,"date":"2021-05-14T15:09:42","date_gmt":"2021-05-14T12:09:42","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/researchers-use-deep-learning-to-denoise-nanopore-data\/"},"modified":"2021-05-14T15:09:42","modified_gmt":"2021-05-14T12:09:42","slug":"researchers-use-deep-learning-to-denoise-nanopore-data","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/researchers-use-deep-learning-to-denoise-nanopore-data\/","title":{"rendered":"#Researchers use deep learning to &#8216;denoise&#8217; nanopore data"},"content":{"rendered":"<p>&#8220;<strong>#Researchers use deep learning to &#8216;denoise&#8217; nanopore data<\/strong>&#8221;<\/p>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2021\/above-the-noise.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2021\/above-the-noise.jpg\" data-sub-html=\"Deep learning helps researchers to find hidden features in resistive pulse signals in nanopore sensing of nanoscale objects. Credit: Osaka University\">\n<figure class=\"article-img\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2021\/above-the-noise.jpg\" alt=\"Above the noise\" title=\"Deep learning helps researchers to find hidden features in resistive pulse signals in nanopore sensing of nanoscale objects. Credit: Osaka University\" width=\"658\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Deep learning helps researchers to find hidden features in resistive pulse signals in nanopore sensing of nanoscale objects. Credit: Osaka University<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>Scientists from the Institute of Scientific and Industrial Research at Osaka University have used machine-learning methods to enhance the signal-to-noise ratio in data collected when tiny spheres are passed through microscopic nanopores cut into silicon substrates. This work may lead to much more sensitive data collection when sequencing DNA or detecting small concentrations of pathogens.<\/p>\n<p>                                                                                Miniaturization has opened the possibility for a wide range of diagnostic tools, such as point-of-care detection of diseases, to be performed quickly and with very small samples. For example, unknown particles can be analyzed by passing them through nanopores and recording tiny changes in the electrical current. However, the intensity of these signals can be very low, and is often buried under random noise. New techniques for extracting the useful information are clearly needed.<\/p>\n<p>Now, scientists from Osaka University have used deep learning to &#8220;denoise&#8221; nanopore data. Most machine learning methods need to be trained with many &#8220;clean&#8221; examples before they can interpret noisy datasets. However, using a technique called Noise2Noise, which was originally developed for enhancing images, the team was able to improve resolution of noisy runs even though no clean data was available. Deep neural networks, which act like layered neurons in the brain, were utilized to reduce the interference in the data.<\/p>\n<p>&#8220;The deep denoising enabled us to reveal faint features in the ionic current signals hidden by random fluctuations,&#8221; first author Makusu Tsutsui says. &#8220;Our algorithm was designed to select features that best represented the input data, thus allowing the computer to detect and subtract the noise from the raw data.&#8221;<\/p>\n<p>The process was repeated many times until the underlying signal was recovered. Essentially, many noisy runs were utilized to produce one clean signal.<\/p>\n<p>&#8220;Our method may expand the capability nanopore sensing for rapid and accurate detection of infection diseases,&#8221; explains senior author Takashi Washio. &#8220;This research may lead to much more accurate diagnostic tests, even when the underlying signal is very weak.&#8221;\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/phys.org\/news\/2020-11-viruses-machine.html\">Sorting out viruses with machine learning<\/a>\n                                        <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Deep learning-enhanced nanopore sensing of single-nanoparticle translocation dynamics. <i>Small Methods<\/i>, DOI: <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1002\/smtd.202100191\">doi.org\/10.1002\/smtd.202100191<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Osaka University<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.osaka-u.ac.jp\/en\"><br \/>\n                                                        <svg><use href=\"https:\/\/techx.b-cdn.net\/tmpl\/v2\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/><\/svg><\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Researchers use deep learning to &#8216;denoise&#8217; nanopore data (2021, May 14)<br \/>\n                                                 retrieved 14 May 2021<br \/>\n                                                 from https:\/\/techxplore.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2021-05-deep-denoise-nanopore.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: Osaka University Scientists from the Institute of Scientific and Industrial Research at Osaka University have used machine-learning methods to enhance the signal-to-noise ratio in data collected when tiny&#8230;<\/p>\n","protected":false},"author":1,"featured_media":249674,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2021\/above-the-noise.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-249673","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/249673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=249673"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/249673\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/249674"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=249673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=249673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=249673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}