{"id":25011,"date":"2020-07-10T20:19:00","date_gmt":"2020-07-10T17:19:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/nanocage-tool-untangles-molecular-spaghetti\/"},"modified":"2020-07-10T20:19:00","modified_gmt":"2020-07-10T17:19:00","slug":"nanocage-tool-untangles-molecular-spaghetti","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/nanocage-tool-untangles-molecular-spaghetti\/","title":{"rendered":"#&#8217;Nanocage&#8217; tool untangles (molecular) spaghetti"},"content":{"rendered":"<p>&#8220;<strong>#&#8217;Nanocage&#8217; tool untangles (molecular) spaghetti<\/strong>&#8221;<\/p>\n<div>\n<div>\n<div data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2020\/inventionquo.jpg\" data-sub-html=\"University of Vermont post-doctoral researcher Mona Sharafi helped build a nanoscale tool that can untie knots of protein, plastic or other polymers. Called a \"nanocage,\" the advance in chemistry promises to help create new kinds of industrial and biological materials. Credit: Joshua Brown\/UVM\" data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2020\/inventionquo.jpg\">\n<figure><img loading=\"lazy\" decoding=\"async\" alt=\"Invention: \"Nanocage\" tool untangles (molecular) spaghetti\" height=\"480\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800\/2020\/inventionquo.jpg\" title=\"University of Vermont post-doctoral researcher Mona Sharafi helped build a nanoscale tool that can untie knots of protein, plastic or other polymers. Called a \"nanocage,\" the advance in chemistry promises to help create new kinds of industrial and biological materials. Credit: Joshua Brown\/UVM\" width=\"800\"><\/img><figcaption>\n                University of Vermont post-doctoral researcher Mona Sharafi helped build a nanoscale tool that can untie knots of protein, plastic or other polymers. Called a &#8220;nanocage,&#8221; the advance in chemistry promises to help create new kinds of industrial and biological materials. Credit: Joshua Brown\/UVM<br \/>\n            <\/figcaption><\/figure>\n<\/div>\n<\/div>\n<p>A team of scientists at the University of Vermont have invented a new tool\u2014they call it a &#8220;nanocage&#8221;\u2014that can catch and straighten out molecule-sized tangles of polymers.<\/p>\n<section>\n      <\/section>\n<p>Once a knotty polymer strand\u2014whether made of protein or plastic\u2014is pulled open &#8220;then we can activate just the polymers we want, while leaving the rest alone, &#8221; says UVM chemist Severin Schneebeli who led the new research. This tool\u2014that works a bit like pulling a wad of thread through a needle hole\u2014&#8221;opens a new way to create custom materials that have never been made before,&#8221; he says. These might include nanoscale pill coatings that wrap around single molecules of medicine or new industrial products assembled from precisely arranged strands of plastic at the atomic scale.<\/p>\n<p>The tool, composed of molecular edges with special &#8220;shape-directing&#8221; hydrogen bonds\u2014and thousands of times smaller than a pinhead\u2014can select out shorter strands of a polymer, leaving longer ones behind, demonstrating that the nanocage can be used to selectively find particular sizes of molecules in a soup of material. &#8220;It&#8217;s selective and that&#8217;s never been done before,&#8221; Schneebeli says. This research is the first time that <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a> has been able distinguish and activate different size polymer chains in a lab\u2014opening the door to new possibilities for precision chemistry.<br \/>\nThe new research was published in the June edition of the journal <i>Chem<\/i>.<\/p>\n<figure itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\"><meta content=\"Invention: \"Nanocage\" tool untangles (molecular) spaghetti\" itemprop=\"name\"><\/meta><meta content=\"https:\/\/youtu.be\/ooQcB-SDrOs\" itemprop=\"url\"><\/meta><meta content=\"This 17-second animation shows a new tool--called a \"nanocage\"--that can catch and straighten out molecule-sized tangles of polymers. It works a bit like pulling a wad of thread through a needle hole--opening a new way to create custom materials that have never been made before. Credit: Schneebeli Lab\/UVM\" itemprop=\"description\"><\/meta><meta content=\"2020-07-10T13:19:07-04:00\" itemprop=\"uploadDate\"><\/meta><meta content=\"https:\/\/img.youtube.com\/vi\/ooQcB-SDrOs\/maxresdefault.jpg\" itemprop=\"thumbnailUrl\"><\/meta><br \/>\n             <iframe allowfullscreen=\"\" frameborder=\"0\" src=\"https:\/\/www.youtube.com\/embed\/ooQcB-SDrOs?color=white\"><\/iframe><figcaption itemprop=\"caption\">This 17-second animation shows a new tool&#8211;called a &#8220;nanocage&#8221;&#8211;that can catch and straighten out molecule-sized tangles of polymers. It works a bit like pulling a wad of thread through a needle hole&#8211;opening a new way to create custom materials that have never been made before. Credit: Schneebeli Lab\/UVM<\/figcaption><\/figure>\n<p><b>Nature knows<\/b><br \/>\nThe abilities of the nanocage are new to science\u2014but not to nature. For billions of years, life has evolved ways to select just the bit of a protein or other biological knot that it wants to untie and turn on\u2014what scientists call &#8220;functionalize.&#8221; But people have had a hard time doing the same thing. &#8220;Despite plenty of examples in biology,&#8221; the UVM scientists write, &#8220;efficient and selective modification of man-made polymers is still difficult.&#8221;<br \/>\nWhether altering biological strands, like DNA, or industrial materials, like plastics, the new tetrahedron-shaped tool promises to let scientists do what nature already does well. &#8220;It took years of hard work in the lab to assemble this tetrahedron before we could test it,&#8221; says Mona Sharafi, the lead author on the new study, and post-doctoral researcher at the Unversity of Vermont who came to the United States from Iran. &#8220;It&#8217;s entirely man-made&#8221; she says, &#8220;but inspired by nature.&#8221;<\/p>\n<p><b>Potent polymers<\/b><br \/>\nThe word polymer comes from a pair of Greek words that mean &#8220;many parts.&#8221; And polymers are just that: materials made from huge molecules comprised of many repeating parts. They&#8217;re found in many everyday products. Some are natural, like rubber and shellac. Many are synthetic, and are used to produce much of the material in everyday life\u2014from shopping bags to diapers, clothing to water pipes. Polymers can be found in tidy long strings at the molecular level\u2014or they can be tied up in godawful knots like a billion strands of micro-spaghetti<br \/>\nNature has had eons to figure out how to both synthesize these huge molecules\u2014biopolymers, like DNA\u2014and how to edit and activate selected portions. People have gotten pretty good at making new synthetic polymers\u2014but not so good at selecting and editing them. Many scientists and engineers\u2014working on new <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>lications for renewable energy (e.g., next-generation solar cells), precision medicine (like delivery of cancer drugs to targeted parts of the body) and advanced electronics (including flexible devices)\u2014would like to have greater control and efficiency working with what the UVM team call &#8220;functional polymers with complex topologies.&#8221; With support from the National Science Foundation and the National Institutes of Health (which supported the computational studies, directed by UVM chemist Jianing Li), the research on the nanocage provides a new tool to do so\u2014 &#8220;to untie the knot, opening polymers that would have been inaccessible before,&#8221; say UVM&#8217;s Mona Sharafi. &#8220;We have opened something big.&#8221;<\/p>\n<hr>\n<\/hr>\n<hr>\n<\/hr>\n<div>\n<p><strong>More information:<\/strong><br \/>\n                                                Mona Sharafi et al, Size-Selective Catalytic Polymer Acylation with a Molecular Tetrahedron, <i>Chem<\/i> (2020).  DOI: 10.1016\/j.chempr.2020.05.011<\/p>\n<div>\n<p><strong>Journal information:<\/strong><br \/>\n                                                                                                            <cite>Chem<\/cite><\/p>\n<p><a href=\"http:\/\/www.cell.com\/chem\/home\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><br \/>\n                                                            <svg><use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"><\/use><\/svg><\/a> <\/p><\/div>\n<\/p><\/div>\n<div>\n<p><strong>Citation<\/strong>:<br \/>\n                                                 &#8216;Nanocage&#8217; tool untangles (molecular) spaghetti (2020, July 10)<br \/>\n                                                 retrieved 10 July 2020<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2020-07-nanocage-tool-untangles-molecular-spaghetti.html<\/p>\n<p>                                            This document is subject to copyright. 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The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener noreferrer\">Science category.<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>if you want to <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/watch-movies-tv-seriess\/\" data-internallinksmanager029f6b8e52c=\"8\" title=\"Watch Movies &amp; TV Series\" target=\"_blank\" rel=\"noopener\">watch Movies<\/a> or Tv Shows go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/dizi.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Dizi.BuradaBiliyorum.Com<\/a> <\/span> for forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;#&#8217;Nanocage&#8217; tool untangles (molecular) spaghetti&#8221; University of Vermont post-doctoral researcher Mona Sharafi helped build a nanoscale tool that can untie knots of protein, plastic or other polymers. Called a &#8220;nanocage,&#8221; the advance in chemistry promises to help create new kinds of industrial and biological materials. Credit: Joshua Brown\/UVM A team of scientists at the University&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[36587,11880],"class_list":["post-25011","post","type-post","status-publish","format-standard","hentry","category-sciencee","tag-nanocage-tool-untangles-molecular-spaghetti","tag-bio-medicine-nanomaterials"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/25011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=25011"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/25011\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=25011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=25011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=25011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}