{"id":251562,"date":"2021-05-17T15:56:34","date_gmt":"2021-05-17T12:56:34","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/virtual-brain-bank-could-help-us-get-the-most-out-of-brain-donation\/"},"modified":"2021-05-17T15:56:34","modified_gmt":"2021-05-17T12:56:34","slug":"virtual-brain-bank-could-help-us-get-the-most-out-of-brain-donation","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/virtual-brain-bank-could-help-us-get-the-most-out-of-brain-donation\/","title":{"rendered":"#Virtual brain bank could help us get the most out of brain donation"},"content":{"rendered":"

“#Virtual brain bank could help us get the most out of brain donation<\/strong>”<\/p>\n

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A virtual brain bank could maximize the potential of brain donation by extending the core physical bank to include existing repositories of clinical tissues and data, according to the authors of a Perspective published today by the Medical Journal of Australia<\/i>.\n <\/p>\n

Dr. Amanda Rush, from the NSW Health Statewide Biobank, and Associate Professor Greg Sutherland, from the Charles Perkins Center at the University of Sydney, wrote that in Australia “that post-mortem brain tissue is a key component of neuroscience<\/a> research.” However, “autopsies in general<\/a> are now uncommon” and “brain removal is not routinely included as part of an autopsy or post mortem examination.”<\/p>\n

“For brain donor programs, brain removal logistics are often complex and costly, with reliance on in-kind support from funeral directors, clinicians and mortuary staff,” Rush and Sutherland wrote.<\/p>\n

“After tissue harvesting, brains require specialist processing expertise and large storage areas, resulting in increased labor and space costs.<\/p>\n

“The timing and finality of brain removal can also have an impact on the collection of longitudinal clinical data, which may require medical records departmental input and\/or facilitation by family members.”<\/p>\n

With the predicted rise in the morbidity and mortality of dementia, and “reported increases in the prevalence of mental health in Australia” there is a growing need for “research into risk factors and therapies for neurological diseases.”<\/p>\n

“In the future, even larger cohorts will be required to examine the probable gene\u2013 environment interactions that confer risk for many sporadic brain diseases,” they wrote.<\/p>\n

“We propose a novel brain banking strategy that maximizes the potential of brain donation by extending the core physical bank to include existing repositories of clinical tissues and data, creating a virtual brain bank.”<\/p>\n

Rush and Sutherland proposed a next-generation brain bank which incorporates alternative technologies into a “suite of products offered to researchers.”<\/p>\n

“An integrated brain bank could extend their involvement to more comprehensive clinical data collection, generation and analysis,” Rush and Sutherland wrote.<\/p>\n

“This would make samples and derivatives such as serum, DNA, images and genetic\/-omic data available for researchers, allowing brain banks to contribute to research on brain diseases for living patients.<\/p>\n

“We suggest extending this app<\/a>roach beyond just a brain focus by “integrating into multi-purpose biobanking initiatives.<\/p>\n

“In this scenario, the brain bank could remain responsible for the characterisation and provision of brain-related tissue and data but be just one component in an integrated resource that characterizes the lifespan of an individual donor.”<\/p>\n

The authors concluded that:<\/p>\n

“To be most effective, biobanking needs to change its modus operandi from a static operation that banks tissue indefinitely to one that is actively involved in the research process\u2014a so-called biolibrary.<\/p>\n

“By integrating with wider biobanking initiatives, next-generation brain banks can contribute to the clinical, pathological and clinicopathological characterisation of a range of tissues and data for researchers of all disease interests.<\/p>\n

“Importantly, a virtual brain bank or brain and body biolibrary will create future research synergies that otherwise would not be achieved.”\n <\/p>\n\n

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‘Zombie’ genes? Research shows some genes come to life in the brain after death\n <\/p><\/div>\n

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\n More information:<\/strong>
\n Amanda Rush et al. The future of brain banking in Australia: an integrated brain and body biolibrary, Medical Journal of Australia<\/i> (2021). DOI: 10.5694\/mja2.51049<\/a><\/p><\/div>\n

\n Provided by
\n Medical Journal of Australia (MJA)<\/p>\n

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Citation<\/strong>:
\n Virtual brain bank could help us get the most out of brain donation (2021, May 17)
\n retrieved 17 May 2021
\n from https:\/\/medicalxpress.com\/news<\/a>\/2021-05-virtual-brain-bank-donation.html<\/p>\n

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