{"id":267506,"date":"2021-06-04T19:30:05","date_gmt":"2021-06-04T16:30:05","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/how-to-retard-time-for-cells\/"},"modified":"2021-06-04T19:30:05","modified_gmt":"2021-06-04T16:30:05","slug":"how-to-retard-time-for-cells","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/how-to-retard-time-for-cells\/","title":{"rendered":"#How to retard time for cells"},"content":{"rendered":"

“#How to retard time for cells<\/strong>”<\/p>\n

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\n Fluorescence images showed that cells did not visibly change morphologically. The slowing down of their dynamics was solely due to the presence of heavy water. Credit: Leipzig University
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Scientists at Leipzig University, in collaboration with colleagues from Germany and England, have succeeded in reversibly slowing down cellular processes. A team of biophysicists led by Professor Josef Alfons K\u00e4s and Dr J\u00f6rg Schnau\u00df were able to show in experiments that cells can be transferred into slow motion without changing the temperature.<\/p>\n


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From a physical point of view, such possibilities have so far only been available in the context of the theory of relativity. The researchers recently published their findings in the renowned journal Advanced Materials<\/i>. Cells are not only our biological building blocks, but also highly dynamic, active systems. The research group led by Professor K\u00e4s has succeeded in significantly reducing these dynamics with heavy water, without damaging the cells.<\/p>\n

“General<\/a>ly, a lot of people know heavy water for its important technical use in nuclear power plants. We took a different app<\/a>roach here and were able to show that for cells, time\u2014or, more specifically, their dynamics\u2014can be significantly slowed down in the presence of heavy water,” said K\u00e4s, who has devoted himself to researching the physical properties of cells and tissue. <\/p>\n

The research showed on various biological levels that the movement of cells and their dynamics was only taking place in slow motion. “It is very intriguing that cellular dynamics can be slowed down at the same temperature. So far, only the theory of relativity has offered such possibilities in the physical context,” explained K\u00e4s. He added that the results form the basis of a method to offer cells and organs longer-lasting protection against degeneration.<\/p>\n

The researchers confirmed this effect with a variety of complementary methods and attributed the observations to an increased interaction between the structural proteins. “Heavy water also forms hydrogen bonds, but these are stronger than in normal aqueous environments. As a result, structural proteins such as actin seem to interact more strongly with one another and briefly stick together. What is spectacular here is that the effects are reversible, with cells showing their native properties again as soon as they are transferred into a normal aqueous medium,” said Dr. J\u00f6rg Schnau\u00df. “What is even more astonishing is that these changes show the fingerprint of a passive material. However, cells are highly active and far from thermodynamic equilibrium. If they behave like a passive material, they are usually dead,” added K\u00e4s.<\/p>\n

However, as the researchers were able to show, this was not the case in their experiments. They now hope to be able to use the knowledge gained to keep cells or even tissue vital for longer. If this approach is confirmed, heavy water could be used for longer storage times, for example during organ transplants.<\/p>\n\n

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Physics of tumours: Cancer cells become fluidised and squeeze through tissue\n <\/p><\/div>\n

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\n More information:<\/strong>
\n J\u00f6rg Schnau\u00df et al, Cells in Slow Motion: Apparent Undercooling Increases Glassy Behavior at Physiological Temperatures, Advanced Materials<\/i> (2021). DOI: 10.1002\/adma.202101840<\/a><\/p><\/div>\n

Provided by
\n Universit\u00e4t Leipzig<\/p>\n

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Citation<\/strong>:
\n How to retard time for cells (2021, June 4)
\n retrieved 5 June 2021
\n from https:\/\/phys.org\/news<\/a>\/2021-06-retard-cells.html<\/p>\n

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