{"id":278700,"date":"2021-06-18T20:37:44","date_gmt":"2021-06-18T17:37:44","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/losartan-found-ineffective-in-reducing-hospitalization-from-mild-covid-19\/"},"modified":"2021-06-18T20:37:44","modified_gmt":"2021-06-18T17:37:44","slug":"losartan-found-ineffective-in-reducing-hospitalization-from-mild-covid-19","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/losartan-found-ineffective-in-reducing-hospitalization-from-mild-covid-19\/","title":{"rendered":"#Losartan found ineffective in reducing hospitalization from mild COVID-19"},"content":{"rendered":"

“#Losartan found ineffective in reducing hospitalization from mild COVID-19<\/strong>”<\/p>\n

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University of Minnesota Medical School researchers determined that the common blood pressure medication, losartan, is not effective in reducing hospitalization for mildly-ill COVID-19 outpatients.\n <\/p>\n

In the multicenter, randomized, double-blinded clinical trial, non-hospitalized patients recently diagnosed with COVID-19 were given either losartan or a placebo and monitored for 15 days. The study’s results, which were published in EClinicalMedicine,<\/i> showed that although losartan does not reduce the likelihood of hospitalization, the medication does not app<\/a>ear to worsen symptoms of COVID-19 or have any significant or harmful side effects on patients with mild COVID-19.<\/p>\n

“Based on our results, there is no benefit to starting losartan for newly diagnosed outpatients with COVID-19, but those who are already taking the medication for pre-existing health conditions should feel safe continuing it,” said Michael Puskarich, MD, an associate professor in the Department of Emergency Medicine at the U of M Medical School and co-principal investigator of this study. He is also an emergency physician at Hennepin Healthcare.<\/p>\n

Conflicting hypotheses since the start of the pandemic led this research team to investigate losartan as a potential treatment option. While some experts believed drugs like losartan may reduce inflammation and help those infected recover, others worried that the drug could worsen COVID-19 symptoms.<\/p>\n

“Given SARS-CoV-2 binding with ACE2 there has been significant research interest into the utility of ACE and AT1R blocking agents to combat COVID-19. This study provides insight that for patients with mild COVID-19, who do not require hospital admission, that there is no benefit or harm from such agents,” said co-principal investigator Christopher Tignanelli, MD, MS, an assistant professor in the Department of Surgery at the U of M Medical School and critical care surgeon with M Health Fairview.<\/p>\n

The same team has been working on another trial for inpatients to evaluate if losartan prevents lung injury in hospitalized patients with COVID-19 pneumonia. They have completed enrollment and are currently analyzing the data.\n <\/p>\n\n

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Could heart medications increase COVID-19 risk?\n <\/p><\/div>\n

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\n More information:<\/strong>
\n Michael A. Puskarich et al, A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19, EClinicalMedicine<\/i> (2021). DOI: 10.1016\/j.eclinm.2021.100957<\/a><\/p><\/div>\n
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\n University of Minnesota Medical School
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\n Citation<\/strong>:
\n Losartan found ineffective in reducing hospitalization from mild COVID-19 (2021, June 18)
\n retrieved 19 June 2021
\n from https:\/\/medicalxpress.com\/news<\/a>\/2021-06-losartan-ineffective-hospitalization-mild-covid-.html<\/p>\n

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