{"id":295104,"date":"2021-07-09T19:23:14","date_gmt":"2021-07-09T16:23:14","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/dying-cells-protect-their-neighbors-to-maintain-tissue-integrity\/"},"modified":"2021-07-09T19:23:14","modified_gmt":"2021-07-09T16:23:14","slug":"dying-cells-protect-their-neighbors-to-maintain-tissue-integrity","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/dying-cells-protect-their-neighbors-to-maintain-tissue-integrity\/","title":{"rendered":"#Dying cells protect their neighbors to maintain tissue integrity"},"content":{"rendered":"

“#Dying cells protect their neighbors to maintain tissue integrity<\/strong>”<\/p>\n

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\"Dying
\n Artistic rendering of dying cells protecting their neighbors to maintain tissue integrity. Holes in epithelium created by uncoordinated cell death are shown in purple. Credit: Institut Pasteur \/ L\u00e9o Valon and Romain Levayer
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To enable tissue renewal, human tissues constantly eliminate millions of cells, without jeopardizing tissue integrity, form and connectivity. The mechanisms involved in maintaining this integrity remain unknown. Scientists from the Institut Pasteur and the CNRS today revealed a new process which allows eliminated cells to temporarily protect their neighbors from cell death, thereby maintaining tissue integrity. This protective mechanism is vital, and if disrupted can lead to a temporary loss of connectivity. The scientists observed that when the mechanism is deactivated, the simultaneous elimination of several neighboring cells compromises tissue integrity. This lack of integrity could be responsible for chronic inflammation. The results of the research were published in the journal Developmental Cell<\/i> on June 2, 2021.<\/p>\n


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Human epithelia are tissues found in several parts of the body (such as the epidermis and internal mucosa). They are composed of layers of contiguous cells that serve as a physical and chemical barrier. This role is constantly being put to the test by both the outside environment and their own renewal. Tissue renewal involves the formation of new cells by cell division and the elimination of dead cells. The mechanisms that regulate the ability of epithelia to maintain their integrity in contexts involving large numbers of eliminated cells remain poorly understood, despite the fact that this situation occurs regularly during embryogenesis or the maintenance of adult tissues. For example, more than ten billion cells can be eliminated every day in an adult intestine. How are these eliminations orchestrated to maintain tissue integrity and connectivity?<\/p>\n

Scientists from the Institut Pasteur and the CNRS set out to identify the mechanisms involved in epithelial integrity and the conditions that can affect epithelial connectivity by using Drosophila (or vinegar flies), an organism studied in the laboratory with a similar epithelial architecture to humans.<\/p>\n


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