{"id":295559,"date":"2021-07-09T19:12:00","date_gmt":"2021-07-09T16:12:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/updated-recommendations-for-managing-hereditary-breast-cancer\/"},"modified":"2021-07-09T19:12:00","modified_gmt":"2021-07-09T16:12:00","slug":"updated-recommendations-for-managing-hereditary-breast-cancer","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/updated-recommendations-for-managing-hereditary-breast-cancer\/","title":{"rendered":"#Updated recommendations for managing hereditary breast cancer"},"content":{"rendered":"

“#Updated recommendations for managing hereditary breast cancer<\/strong>”<\/p>\n

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\"ASCO<\/figure>\n<\/div>\n<\/div>\n

(HealthDay)\u2014One year of adjuvant olaparib should be offered to patients with high-risk early-stage human epidermal growth factor receptor 2 (HER2)-negative breast cancer and germline BRCA<\/i> mutations after completion of (neo)adjuvant chemotherapy and local treatment, according to a rapid recommendation update published by the American Society for Clinical Oncology (ASCO).\n <\/p>\n

Following presentation of the results from the OlympiA randomized controlled trial at the 2021 ASCO Annual Meeting and publication in the New England Journal of Medicine<\/i>, ASCO updated its recommendations for the management of hereditary breast cancer.<\/p>\n

According to the updated recommendation, one year of adjuvant olaparib should be offered after completion of (neo)adjuvant chemotherapy and local treatment, including radiation, for patients with early-stage, HER2-negative breast cancer with a high risk for recurrence and germline BRCA1<\/i> or BRCA2<\/i> pathogenic or likely pathogenic variants. For patients who had surgery first, one year of adjuvant olaparib should be offered to those with trip<\/a>le-negative breast cancer (TNBC) and tumor size >2 cm or any involved lymph nodes. Among patients with hormone receptor-positive disease, adjuvant olaparib should be offered to those with at least four involved axillary lymph nodes. Additional recommendations for adjuvant olaparib address those with TNBC or hormone receptor-positive disease who have residual cancer.<\/p>\n

“Guideline updates have traditionally required months to review new data, assemble an expert panel, develop, app<\/a>rove, and publish recommendations\u2014making it difficult to provide timely support to clinicians seeking to keep abreast of rapidly advancing research,” Clifford A. Hudis, M.D., chief executive officer of ASCO, said in a statement. “ASCO’s new rapid guideline updating strategy is meant to address this need by providing rapid evidence review and dissemination of practice-changing trial results.”\n <\/p>\n\n

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New findings offer improved therapy of early-stage, BRCA mutation-associated breast cancer\n <\/p><\/div>\n

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\n More information:<\/strong>
\n Rapid Recommendation Update<\/a><\/p><\/div>\n

\n Copyright \u00a9 2021 HealthDay<\/a>. All rights reserved.<\/p>\n

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Citation<\/strong>:
\n Updated recommendations for managing hereditary breast cancer (2021, July 9)
\n retrieved 9 July 2021
\n from https:\/\/medicalxpress.com\/news<\/a>\/2021-07-hereditary-breast-cancer.html<\/p>\n

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\n part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n