{"id":31399,"date":"2020-07-21T17:43:00","date_gmt":"2020-07-21T14:43:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/influenza-virus-induced-oxidized-dna-activates-inflammasomes\/"},"modified":"2020-07-21T17:43:00","modified_gmt":"2020-07-21T14:43:00","slug":"influenza-virus-induced-oxidized-dna-activates-inflammasomes","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/influenza-virus-induced-oxidized-dna-activates-inflammasomes\/","title":{"rendered":"#Influenza virus-induced oxidized DNA activates inflammasomes"},"content":{"rendered":"

“#Influenza virus-induced oxidized DNA activates inflammasomes<\/strong>”<\/p>\n

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\"DNA\"<\/img>
\n Credit: Pixabay\/CC0 Public Domain
\n <\/figcaption><\/figure>\n<\/div>\n<\/div>\n

Both influenza virus M2, a proton-selective ion channel essential for efficient viral replication, and PB1-F2 protein, which localizes to the mitochondria and attenuates host antiviral immunity, are involved in the inflammatory response by stimulating NLRP3 inflammasome-dependent IL-1\u03b2 secretion. However, the precise mechanisms by which these viral proteins activate the NLRP3 inflammasome remain unclear.<\/p>\n

In this study, a research group at The Institute of Medical Science<\/a>, The University of Tokyo (IMSUT) observed nucleus- and mitochondria-derived double-stranded DNA (dsDNA) in extracellular web-like structures in the cytoplasm and extracellular space around influenza virus-infected macrophages.<\/p>\n

According to lead scientist Takeshi Ichinohe, Associate Professor, Division of Viral Infection of IMSUT, Oxidized DNA was included in these DNAs, and the research group found that the ion channel activity of the M2 protein and mitochondrial localization of the PB1-F2 protein is required for oxidized DNA release. While the oxidized DNA enhanced influenza virus-induced IL-1\u03b2 secretion, inhibition of mitochondrial reactive oxygen species decreased the virus-induced IL-1\u03b2 secretion. In addition, they showed that influenza virus stimulates IL-1\u03b2 secretion from macrophages in a manner that is dependent on AIM2, a cytosolic DNA sensor. These results provide a missing link between influenza viral proteins and NLRP3 inflammaseome activation, and reveal the importance of influenza virus-induced oxidized DNA in inflammasomes activation.<\/p>\n

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More information:<\/strong>
\n Miyu Moriyama et al, Influenza Virus-Induced Oxidized DNA Activates Inflammasomes, iScience<\/i> (2020). DOI: 10.1016\/j.isci.2020.101270\n <\/div>\n

Provided by
\n The Institute of Medical Science, The University of Tokyo<\/p>\n

\n Citation<\/strong>:
\n Influenza virus-induced oxidized DNA activates inflammasomes (2020, July 21)
\n retrieved 21 July 2020
\n from https:\/\/phys.org\/news<\/a>\/2020-07-influenza-virus-induced-oxidized-dna-inflammasomes.html<\/p>\n

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“#Influenza virus-induced oxidized DNA activates inflammasomes” Credit: Pixabay\/CC0 Public Domain Both influenza virus M2, a proton-selective ion channel essential for efficient viral replication, and PB1-F2 protein, which localizes to the mitochondria and attenuates host antiviral immunity, are involved in the inflammatory response by stimulating NLRP3 inflammasome-dependent IL-1\u03b2 secretion. However, the precise mechanisms by which these…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[10586,41891],"class_list":["post-31399","post","type-post","status-publish","format-standard","hentry","category-sciencee","tag-cell-microbiology-molecular-computational-biology","tag-influenza-virus-induced-oxidized-dna-activates-inflammasomes"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/31399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=31399"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/31399\/revisions"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=31399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=31399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=31399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}