{"id":333974,"date":"2021-09-02T21:00:05","date_gmt":"2021-09-02T18:00:05","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/cavalier-king-charles-spaniels-carry-more-harmful-genetic-variants-than-other-breeds\/"},"modified":"2021-09-02T21:00:05","modified_gmt":"2021-09-02T18:00:05","slug":"cavalier-king-charles-spaniels-carry-more-harmful-genetic-variants-than-other-breeds","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/cavalier-king-charles-spaniels-carry-more-harmful-genetic-variants-than-other-breeds\/","title":{"rendered":"#Cavalier King Charles spaniels carry more harmful genetic variants than other breeds"},"content":{"rendered":"

“#Cavalier King Charles spaniels carry more harmful genetic variants than other breeds<\/strong>”<\/p>\n

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\n Comparisons of dachshunds with and without signs of heart disease were used to help identify mutations that potentially predispose cavalier King Charles spaniels to develop MMVD. Credit: M\u00e5ns Engelbrektsson, Swedish Kennel Club, CC-BY 4.0 (creativecommons.org\/licenses\/by\/4.0\/)
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Recent dog breeding practices have loaded up cavalier King Charles spaniels with disease-causing mutations, including variants linked to the common heart condition, myxomatous mitral valve disease (MMVD). Erik Axelsson of Uppsala University and colleagues published these new findings September 2nd in the journal PLOS Genetics<\/i>.<\/p>\n


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The past 300 years of dog breeding have created an incredible diversity of breeds with various sizes, shapes, and abilities. Unfortunately, this process has also caused many breeds to become more inbred and more likely to inherit genetic diseases. The study’s researchers wanted to know whether recent breeding practices had increased the number of disease-causing variants in dogs. They sequenced entire genomes from 20 dogs from eight common breeds, such as beagles, German shepherds, and golden retrievers. They found that the cavalier King Charles spaniel, which experienced the most intense breeding, carried more harmful genetic variants than the other breeds they examined.<\/p>\n

The researchers also looked for genetic variants in the cavalier King Charles spaniel genomes linked to MMVD. In this condition, the mitral valve in the heart degenerates, allowing blood to leak from the left ventricle back into the left atrium. They identified two genetic variants linked to the disease, which app<\/a>ear to regulate a gene that codes for a common protein in heart muscle. The findings offer a potential explanation for why the cavalier King Charles spaniel is predisposed to develop the disease.<\/p>\n

The especially large number of potentially harmful genes in the genomes of cavalier King Charles spaniels, compared to other dogs, likely resulted from its breeding history. Records suggest that small spaniel-type dogs have existed for at least 1,000 years and were popular at royal courts for several hundred years throughout Asia and Europe, including at the court of King Charles II (1630-1685). These spaniels experienced several “bottlenecks” where only a small percentage of the population passed on their genes to the next generation. The bottlenecks may have made the harmful genes more common in the cavalier King Charles spaniel genome before the dog achieved recognition as a breed in 1945.<\/p>\n

Axelsson adds, “We find that recent breeding may have led to an accelerated accumulation of harmful mutations in certain dog breeds. In the Cavalier King Charles spaniel specifically, one or several of these mutations affect heart muscle protein NEBL and may predispose this breed to devastating heart disease.”<\/p>\n\n

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Studies offer new hope for diagnosis of Chiari-malformation in toy dog breeds\n <\/p><\/div>\n

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\n More information:<\/strong>
\n Axelsson E, Ljungvall I, Bhoumik P, Conn LB, Muren E, Ohlsson \u00c5, et al. (2021) The genetic consequences of dog breed formation\u2014Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels. PLoS Genet<\/i> 17(9): e1009726. doi.org\/10.1371\/journal.pgen.1009726<\/a><\/p><\/div>\n
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Citation<\/strong>:
\n Cavalier King Charles spaniels carry more harmful genetic variants than other breeds (2021, September 2)
\n retrieved 2 September 2021
\n from https:\/\/phys.org\/news<\/a>\/2021-09-cavalier-king-charles-spaniels-genetic.html<\/p>\n

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