{"id":344386,"date":"2021-09-23T17:25:04","date_gmt":"2021-09-23T14:25:04","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/how-modernas-mrna-technology-is-revolutionizing-health-care\/"},"modified":"2021-09-23T17:25:04","modified_gmt":"2021-09-23T14:25:04","slug":"how-modernas-mrna-technology-is-revolutionizing-health-care","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/how-modernas-mrna-technology-is-revolutionizing-health-care\/","title":{"rendered":"#How Moderna&#8217;s mRNA technology is revolutionizing health care"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3688bb8256c\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3688bb8256c\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/how-modernas-mrna-technology-is-revolutionizing-health-care\/#Ongoing_efficacy_adolescent_approval_booster_shots\" >Ongoing efficacy, adolescent approval, booster shots<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/buradabiliyorum.com\/en\/how-modernas-mrna-technology-is-revolutionizing-health-care\/#mRNA_technology_as_the_future_of_medicine\" >mRNA technology as the future of medicine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/buradabiliyorum.com\/en\/how-modernas-mrna-technology-is-revolutionizing-health-care\/#Robust_R_D_investments_lead_the_way_to_new_ways_to_treat_diseases\" >Robust R&amp;D investments lead the way to new ways to treat diseases<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/buradabiliyorum.com\/en\/how-modernas-mrna-technology-is-revolutionizing-health-care\/#Important_Safety_Information\" >Important Safety Information<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/buradabiliyorum.com\/en\/how-modernas-mrna-technology-is-revolutionizing-health-care\/#Sources\" >Sources<\/a><\/li><\/ul><\/nav><\/div>\n<p>&#8220;<strong>#How Moderna&#8217;s mRNA <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> is revolutionizing health care<\/strong>&#8221;<\/p>\n<div>\n                                                                        <strong>Created by <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">Media<\/a>planet<\/strong><\/p>\n<p><em>This article was made possible with support from ModernaTx<\/em><\/p>\n<p>The fall season is upon us and with it brings a lot of unknowns about the ever-changing COVID-19 variants.<\/p>\n<p>In this climate of uncertainty, vaccination will be key to staying healthy and fighting our way out of the pandemic. \u201c<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/general\/\" data-internallinksmanager029f6b8e52c=\"3\" title=\"General\" target=\"_blank\" rel=\"noopener\">General<\/a>ly, when the public is well vaccinated, whether for flu, meningitis, pneumonia or shingles, we see less disease, and less burden on the healthcare system,\u201d says Dr. Vivien Brown, a family physician in private practice in Toronto.<\/p>\n<p>\u201cWith COVID-19 specifically, the vaccines have had a significant impact on driving down the number of hospitalizations, and deaths, and in helping to create a cocooning effect to protect people who can\u2019t be vaccinated,\u201d she says.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Ongoing_efficacy_adolescent_approval_booster_shots\"><\/span><strong>Ongoing efficacy, adolescent approval, booster shots<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Moderna\u2019s efforts are critical in the global fight against COVID-19. To date almost 146<sup>1<\/sup> million doses of the Moderna\u2019s COVID vaccine have been administered in the US and over 7.2 million in Canada.<sup>2<\/sup> As the pandemic evolves, Moderna is staying ahead of the <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a> with mRNA technology.<\/p>\n<p>Though the variants, waning immunity, and breakthrough infections are concerning, new data published in <em>Science<\/em><sup>3<\/sup> reported that the majority of individuals vaccinated with the Moderna COVID-19 vaccine, maintained antibodies against SARS-CoV-2 variants for six months after the second dose.<\/p>\n<p>On August 27, 2021, Moderna\u2019s COVID-19 vaccine was authorized by Health Canada for use in adolescent populations aged 12 and above. \u201cWe see that as a major win in the fight against COVID-19, says Dr. Beverly Francis, PhD, Director, Scientific Leadership \u2013 North America at Moderna. \u201cVaccinating as many eligible Canadians as possible limits the human pool that serves as a viral reservoir, limits the spread of this virus, and greatly limits the virus\u2019 ability to evolve and mutate into more transmissible or infective strains,\u201d says Dr. Francis.<\/p>\n<p>Anticipating the combination of the force of the current Delta variant, waning immunity, and pandemic fatigue will require further defensive action. Moderna is already preparing by advancing its mRNA-1273 vaccine as a booster candidate<sup>4<\/sup>. \u201cInitial research has found it to be effective in boosting responses broadly against both the ancestral and major variant strains of the virus, and the safety profile of the booster was similar to that observed previously for dose 2 of the vaccine,\u201d says Dr. Francis.<\/p>\n<p>Finally, to ensure a steady supply, Moderna has been working closely with the Government of Canada to secure supply for up to 105 million doses of the COVID vaccine and its booster candidates, when authorized, for delivery through to 2024.<sup>5<\/sup><\/p>\n<h2><span class=\"ez-toc-section\" id=\"mRNA_technology_as_the_future_of_medicine\"><\/span><strong>mRNA technology as the future of medicine<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The Moderna COVID-19 vaccine is the first mRNA vaccine that the company has brought to market. mRNA technology is built on the foundation that our bodies can create their own defense mechanism. mRNA-based vaccines are designed to deliver the instructions to our cells to create proteins that help activate the immune response against the virus. \u201cIt\u2019s like giving the cell a recipe to follow, in this case a recipe to produce a spike protein, which then stimulates the antibodies,\u201d says Dr. Brown.<\/p>\n<p>Moderna\u2019s COVID-19 mRNA vaccines build on more than a decade of basic and <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>lied mRNA science, delivery technology, and manufacturing. The precision, speed, and flexibility of the platform enabled Moderna to respond quickly to the COVID-19 pandemic, providing an effective vaccine in just under a year. \u201cIt\u2019s such an elegant and precise platform,\u201d says Dr. Brown. \u201cIt\u2019s just so fortuitous that it was ready at a time when we urgently needed it,\u201d says Dr. Brown.<\/p>\n<p>Moderna\u2019s mRNA platform and approach will enable the company to research, develop, and manufacture medicines in new and potentially ground-breaking ways that can help single patients with individualized therapy, or millions of patients with infectious diseases. \u201cWe\u2019re essentially industrializing mRNA technology and scaling the scope of therapeutic targets to address diseases, viruses, and pathogens in ways that were previously considered unimaginable,\u201d says Dr. Francis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Robust_R_D_investments_lead_the_way_to_new_ways_to_treat_diseases\"><\/span><strong>Robust R&amp;D investments lead the way to new ways to treat diseases<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In 2020, Moderna invested $1.37 billion on R&amp;D<sup>6<\/sup> \u2013 and $2.3 billion over the past three years. Moderna\u2019s mRNA pipeline includes 23 projects in development, and 15 clinical study programs currently underway.<sup>7<\/sup><br \/>\n<img loading=\"lazy\" decoding=\"async\" data-sizes=\"auto\" class=\"aligncenter size-full wp-image-1226534 lazyload\" src=\"https:\/\/www.macleans.ca\/wp-content\/uploads\/2021\/09\/moderna-infographic-sept-.png\" alt=\"\" width=\"254\" height=\"606\"\/>Within the infectious disease modality Moderna currently has nine vaccines in development for major unmet needs, including next-generation COVID-19 vaccines, influenza, cytomegalovirus (CMV), respiratory syncytial virus (RSV), human metapneumovirus (hMPV), parainfluenza (PIV3), and Zika. It has an additional 12 medicines in development across four therapeutic areas \u2013 immune-oncology, rare diseases like propionic acidemia, cardiovascular, and autoimmune diseases.<sup>8<\/sup><\/p>\n<p>\u201cThe breadth of the mRNA platform and its capabilities is really energizing,\u201d says Dr. Francis. \u201cIf you understand what mRNA is at its core and figure out how to deliver it, as we have done, you can see we\u2019re just at the beginning,\u201d she says.<\/p>\n<p>Clinical trials are underway to assess two of Moderna\u2019s new respiratory vaccine candidates \u2013 one is a quadrivalent mRNA seasonal flu vaccine candidate, and the other aims to protect against respiratory syncytial virus (RSV)<sup>9<\/sup>. \u201cOur vision is to develop a combination respiratory vaccine for adult and older adult populations, combining seasonal flu, RSV, and COVID-19 booster all in one shot,\u201d says Dr. Francis. \u201cDoing many things in parallel to protect against three serious respiratory viruses at once is typical of the spirit and boldness of Moderna,\u201d says Dr. Francis.<\/p>\n<p>To explore how mRNA science is being used in vaccines, visit <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659404&amp;s=659402\">Moderna Canada.<\/a><\/p>\n<hr\/>\n<h2><span class=\"ez-toc-section\" id=\"Important_Safety_Information\"><\/span>Important Safety Information<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>SPIKEVAX\u2122 (elasomeran mRNA vaccine) is a vaccine used to prevent the coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus. It can be given to individuals aged 12 years and older. As with any vaccine, SPIKEVAX may not fully protect all those who receive it. Even after you have had both doses of the vaccine, continue to follow the recommendations of local public health officials to prevent the spread of COVID-19. Individuals may not be optimally protected until after receiving the second dose of the vaccine.<\/em><\/p>\n<p><em>The most common or very common side effects of SPIKEVAX are pain at the injection site, tiredness, headache, muscle ache and stiffness, chills, fever, swelling or redness at the injection site, nausea and\/or vomiting and enlarged lymph nodes. Allergic reactions may also occur.<\/em><\/p>\n<p><em>Vaccination may not be suitable for everyone, so ask your healthcare professional if SPIKEVAX is right for you. Full product information can be found on <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659404&amp;s=659402\">https:\/\/www.modernacovid19global.com\/ca\/<\/a>. To report an adverse event, please call 1-866-MODERNA (1-866-663-3762).<\/em><\/p>\n<p><em>\u00a9 2021 Moderna, Inc.<\/em><\/p>\n<p><em>ISI-0006 09\/2021<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Sources\"><\/span>Sources<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><sup>1 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659406&amp;s=659402\">Centres for Disease Control and Prevention. COVID-19 vaccinations in the United States. U.S Department of Health &amp; Human Services: September 2, 2021.<\/a><\/p>\n<p><sup>2 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659408&amp;s=659402\">Public Health Agency of Canada. Canadian COVID-19 vaccination coverage report. Ottawa: Public Health Agency of Canada; August 21, 2021.<\/a><\/p>\n<p><sup>3 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659410&amp;s=659402\">Moderna press release, August 12, 2021.<\/a><\/p>\n<p><sup>4 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659412&amp;s=659402\">Moderna press release, September 1, 2021.<\/a><\/p>\n<p><sup>5, 7 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659414&amp;s=659402\">Moderna press release, August 16, 2021.<\/a><\/p>\n<p><sup>6 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659416&amp;s=659402\">Moderna press release, February 25, 2021.<\/a><a rel=\"nofollow noopener\" target=\"_blank\" href=\"#_ftnref7\" name=\"_ftn7\"><\/p>\n<p><sup>8 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659418&amp;s=659402\">2Q2021 Moderna Earnings Call Business Update presentation, August 5, 2021.<\/a> (slide 9).<\/p>\n<p><sup>9 <\/sup><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/sr.studiostack.com\/c\/link?l=659420&amp;s=659402\">2Q2021 Moderna Earnings Call Business Update presentation, August 5, 2021.<\/a> (slide 34).<br \/>\n<span class=\"ctx-article-root\"><!-- --><\/span><\/p><\/div>\n<p><script async defer crossorigin=\"anonymous\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">News<\/a> articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/general\/\" target=\"_blank\" rel=\"noopener\">General category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/www.macleans.ca\/sponsored\/mrna-revolutionizing-health-care\/\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;#How Moderna&#8217;s mRNA technology is revolutionizing health care&#8221; Created by Mediaplanet This article was made possible with support from ModernaTx The fall season is upon us and with it brings a lot of unknowns about the ever-changing COVID-19 variants. In this climate of uncertainty, vaccination will be key to staying healthy and fighting our way&#8230;<\/p>\n","protected":false},"author":1,"featured_media":344387,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/www.macleans.ca\/wp-content\/uploads\/2021\/09\/MODERNA_3_FEATURE_TP_CHE-766x431.jpg","fifu_image_alt":"","footnotes":""},"categories":[1],"tags":[116589],"class_list":["post-344386","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","tag-mediaplanet0921"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/344386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=344386"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/344386\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/344387"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=344386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=344386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=344386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}