{"id":348976,"date":"2021-10-05T19:56:20","date_gmt":"2021-10-05T16:56:20","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/implanted-device-stimulates-patients-brain-treats-severe-depression-researchers-find\/"},"modified":"2021-10-05T19:56:20","modified_gmt":"2021-10-05T16:56:20","slug":"implanted-device-stimulates-patients-brain-treats-severe-depression-researchers-find","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/implanted-device-stimulates-patients-brain-treats-severe-depression-researchers-find\/","title":{"rendered":"#Implanted device stimulates patient\u2019s brain, treats severe depression, researchers find"},"content":{"rendered":"<p>&#8220;<strong>#Implanted device stimulates patient\u2019s brain, treats severe depression, researchers find<\/strong>&#8221;<\/p>\n<div>\n<aside class=\"single__inline-module alignleft\">\n<\/aside>\n<p>A woman with severe depression saw near-im<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a>te relief when treated with a surgically implanted device to stimulate the neural circuit causing the illness, researchers at the University of California San Francisco announced Monday.<\/p>\n<p>The so-called \u201cdeep brain stimulation\u201d (DBS) device was described as the equivalent of a pacemaker for the brain, according to a university release posted Monday, with a\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41591-021-01480-w\">report\u00a0<\/a>on the proof-of-principle trial published in the Nature Medicine journal.\u00a0<\/p>\n<p>\u201cThis study points the way to a new paradigm that is desperately needed in psychiatry,\u201d Andrew Krystal, PhD, professor of psychiatry and member of the\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/weill.ucsf.edu\/\">UCSF Weill Institute for Neurosciences<\/a>, said in a statement. \u201cWe\u2019ve developed a precision-medicine <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach that has successfully managed our patient\u2019s treatment-resistant depression by identifying and modulating the circuit in her brain that\u2019s uniquely associated with her symptoms.\u201d<\/p>\n<p>Researchers said that prior clinical trials on DBS only indicated limited success in treating depression because most devices offer constant electrical stimulation, usually in one area of the brain, whereas depression may affect different areas of the brain for different people. This time, the early findings were deemed successful because researchers discovered a neural biomarker, described as \u201ca specific pattern of brain activity that indicates the onset of symptoms,\u201d and then customized the device to respond only upon detection of that pattern.<\/p>\n<p>The team of researchers cautioned that the findings stemmed from the first patient in the trial, and more work needs to be done. Nevertheless, the personalized therapy involved placing an electrode lead in the patient\u2019s brain area found with the biomarker to monitor activity, and another lead was placed in the patient\u2019s depression circuit, that when treated, best relieved the patient\u2019s mood symptoms.\u00a0<\/p>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"682\" src=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2021\/10\/depression-09.jpg?quality=90&amp;strip=all&amp;w=1024\" alt=\"The study, which appears in the Oct. 4, 2021, issue of Nature Medicine, represents a landmark success in the years-long effort to apply advances in neuroscience to the treatment of psychiatric disorders.\" class=\"wp-image-19702410\" srcset=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2021\/10\/depression-09.jpg?quality=90&amp;strip=all&amp;w=1535 1536w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2021\/10\/depression-09.jpg?quality=90&amp;strip=all 1024w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2021\/10\/depression-09.jpg?quality=90&amp;strip=all&amp;w=512 512w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\"\/><figcaption>The study, which appears in the Oct. 4, 2021, issue of Nature Medicine, represents a landmark success in the years-long effort to apply advances in neuro<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a> to the treatment of psychiatric disorders.<\/figcaption><figcaption><span class=\"credit\">Maurice Ramirez<\/span><\/figcaption><\/figure>\n<p>When the first lead \u201cdetected the biomarker, the device signaled the other lead to deliver a tiny (1mA) dose of electricity for 6 seconds, which caused the neural activity to change, the\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.ucsf.edu\/news\/2021\/09\/421541\/treating-severe-depression-demand-brain-stimulation\">release\u00a0<\/a>reads. Researchers assessed the approach in June under an FDA investigational device exemption, and according to the university, FDA approval for the treatment is \u201cstill far down the road.\u201d<\/p>\n<p>However, the patient\u2019s near-immediate benefit contrasted to a reported 4-8 week delay of standard treatment models and her symptoms have been eased for over 15 months since the device was implanted, according to the university.<\/p>\n<p>\u201cI was at the end of the line,\u201d said the patient, Sarah, who requested to be identified by her first name. \u201cI was severely depressed. I could not see myself continuing if this was all I\u2019d be able to do, if I could never move beyond this. It was not a life worth living.\u201d<\/p>\n<p>The findings were said to have resulted from former President Obama\u2019s BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative in 2014, followed by studies led by UCSF neurosurgeon Dr.\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/profiles.ucsf.edu\/edward.chang\">Edward Chang<\/a>\u00a0and others on depression and anxiety among patients surgically treated for epilepsy, finding that new areas of the brain could be stimulated to alleviate depressed mood, among other results.<\/p>\n<p>\u201cThe effectiveness of this therapy showed that not only did we identify the correct brain circuit and biomarker, but we were able to replicate it at an entirely different, later phase in the trial using the implanted device,\u201d said first author Katherine Scangos in a statement. \u201cThis success in itself is an incredible advancement in our knowledge of the brain function that underlies mental illness.\u201d<\/p>\n<p>The treated patient, Sarah, said that a combination of the therapy and self-care has so far stopped a cycle of irrational thoughts and emotional triggers.\u00a0<\/p>\n<p>Further research efforts will examine varying circuits across patients and whether biomarkers or brain circuits change over time during the treatment period, Scangos said.\n                        <\/p><\/div>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">News<\/a> articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/news\/\" target=\"_blank\" rel=\"noopener\">News category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/nypost.com\/2021\/10\/05\/implanted-device-stimulates-patients-brain-treats-severe-depression-researchers-find\/\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;#Implanted device stimulates patient\u2019s brain, treats severe depression, researchers find&#8221; A woman with severe depression saw near-immediate relief when treated with a surgically implanted device to stimulate the neural circuit causing the illness, researchers at the University of California San Francisco announced Monday. The so-called \u201cdeep brain stimulation\u201d (DBS) device was described as the equivalent&#8230;<\/p>\n","protected":false},"author":1,"featured_media":348977,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2021\/10\/depression-12.jpeg?quality=90&strip=all&w=1024","fifu_image_alt":"","footnotes":""},"categories":[70897],"tags":[117067,70276,73745,5047,70989,61514,4965],"class_list":["post-348976","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-10-5-21","tag-brains","tag-depression","tag-health","tag-mental-health","tag-research","tag-technology"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/348976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=348976"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/348976\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/348977"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=348976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=348976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=348976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}