{"id":412021,"date":"2022-03-04T12:20:07","date_gmt":"2022-03-04T09:20:07","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/researchers-develop-new-treatment-to-combat-obesity-and-heart-disease-2\/"},"modified":"2022-03-04T12:20:07","modified_gmt":"2022-03-04T09:20:07","slug":"researchers-develop-new-treatment-to-combat-obesity-and-heart-disease-2","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/researchers-develop-new-treatment-to-combat-obesity-and-heart-disease-2\/","title":{"rendered":"#Researchers develop new treatment to combat obesity and heart disease"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3f9187b90aa\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3f9187b90aa\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/researchers-develop-new-treatment-to-combat-obesity-and-heart-disease-2\/#%E2%80%9CResearchers_develop_new_treatment_to_combat_obesity_and_heart_disease%E2%80%9D\" >&#8220;Researchers develop new treatment to combat obesity and heart disease&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CResearchers_develop_new_treatment_to_combat_obesity_and_heart_disease%E2%80%9D\"><\/span>&#8220;Researchers develop new treatment to combat obesity and heart disease&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2018\/5b8fad320b89a.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2018\/5b8fad320b89a.jpg\" data-sub-html=\"3D Model of the heart by Dr. Matthew Bramlet. Credit: NIH\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2018\/5b8fad320b89a.jpg\" alt=\"heart\" title=\"3D Model of the heart by Dr. Matthew Bramlet. Credit: NIH\" width=\"800\" height=\"529\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                3D Model of the heart by Dr. Matthew Bramlet. Credit: NIH<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>An interdisciplinary research team at The University of Texas at San Antonio has successfully developed an innovative inhibitor that shows promise in fighting obesity and potentially preventing heart disease. Francis Yoshimoto, an assistant professor in the UTSA College of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s&#8217; Department of Chemistry, is leading a team that developed an anti-obesity drug that blocks the effects of cytochrome P450 8B1, the enzyme linked to cholesterol absorption and obesity.\n                                                <\/p>\n<p>                                                                                Yoshimoto collaborated with Eunhee Chung, an associate professor in the UTSA College of Health, Community and Policy&#8217;s Department of Kinesiology to test the new drug. After designing and synthesizing it, Yoshimoto sent test samples to Chung&#8217;s National Institutes of Health-funded laboratory, where she and her research team are conducting research on the effects of bioactive compounds\u2014chemicals found in small amounts in plants and certain foods\u2014and how exercise can be used to treat obesity and associated metabolic disorders.<\/p>\n<p>Their research findings were published in the February 2022 issue of the scientific journal, <i>Steroids<\/i>.<\/p>\n<p>&#8220;Growing up, I dreamed of helping my family members, who were affected by obesity and heart disease and other medical conditions,&#8221; Yoshimoto said. &#8220;This dream is now turning into a reality, as we have developed a small molecule that can be used to fight obesity, a problem seen in many families around the world.&#8221;<\/p>\n<p>&#8220;As an exercise physiologist, I truly believe exercise is the best medicine to fight against noncommunicable diseases,&#8221; added Chung. &#8220;Unfortunately, the adherence to exercise is quite low, and the prevalence of obesity is continuously rising. Based on promising data, I have high hopes of further testing Dr. Yoshimoto&#8217;s inhibitor.&#8221;<\/p>\n<p>UTSA&#8217;s drug has the potential to stop the activity of P450 8B1, the enzyme that creates cholic acid in the body. This inhibition, in turn, decreases cholesterol absorption. This process may hold the key to treating obesity-associated metabolic disorders and other diseases linked to obesity, such as heart disease and diabetes.<\/p>\n<p>The team&#8217;s research included treating mice with the inhibitor drug for seven days. The result was a decrease in the levels of glucose in their blood\u2014despite having been fed a high-fat and high-sucrose diet\u2014without affects to their body weight. The results demonstrate how a P450 8B1 inhibitor could lead to a healthier metabolic profile and its potential could lead to developing a therapeutic strategy to treat obesity-associated insulin resistance.<\/p>\n<p>Yoshimoto and Chung&#8217;s work is representative of UTSA&#8217;s mission to develop solutions for complex challenges that will improve the health and well-being of society. Creating a drug effective in preventing obesity could improve quality of life around the world.<\/p>\n<p>According to the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight:\/\/\">World Health Organization<\/a>, 1.9 billion adults worldwide were overweight in 2016, and 650 million were classified as obese. Closer to home, one in every four deaths in the U.S. is due to heart disease, of which obesity is a major contributor. Locally, 71% of adults are overweight or obese, according to a <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.sanantonio.gov\/Portals\/0\/Files\/health\/News\/Reports\/StrategicPlan.pdf\">recent report<\/a> from the San Antonio Metropolitan Health District.<\/p>\n<p>&#8220;These results show how our research in synthetic chemistry can significantly contribute to the well-being of society by treating obesity and heart disease,&#8221; Yoshimoto said.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Scientists design protein blockers to fight obesity and heart disease\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Eunhee Chung et al, A synthesis of a rationally designed inhibitor of cytochrome P450 8B1, a therapeutic target to treat obesity, <i>Steroids<\/i> (2021).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"http:\/\/dx.doi.org\/10.1016\/j.steroids.2021.108952\">DOI: 10.1016\/j.steroids.2021.108952<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of Texas at San Antonio<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/www.utsa.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Researchers develop new treatment to combat obesity and heart disease (2022, March  4)<br \/>\n                                                 retrieved  4 March 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-treatment-combat-obesity-heart-disease.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: NIH An interdisciplinary research team at The University of Texas at San Antonio has successfully developed an innovative inhibitor that shows promise in fighting obesity and potentially preventing heart disease. Francis Yoshimoto, an assistant professor&#8230;<\/p>\n","protected":false},"author":1,"featured_media":412023,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2018\/5b8fad320b89a.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-412021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/412021","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=412021"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/412021\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/412023"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=412021"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=412021"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=412021"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}