{"id":416736,"date":"2022-03-16T01:37:00","date_gmt":"2022-03-15T22:37:00","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/how-a-skin-graft-could-be-the-next-addiction-treatment\/"},"modified":"2022-03-16T01:37:00","modified_gmt":"2022-03-15T22:37:00","slug":"how-a-skin-graft-could-be-the-next-addiction-treatment","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/how-a-skin-graft-could-be-the-next-addiction-treatment\/","title":{"rendered":"#How a skin graft could be the next addiction treatment"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3f9b160ec3a\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3f9b160ec3a\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/how-a-skin-graft-could-be-the-next-addiction-treatment\/#%E2%80%9CHow_a_skin_graft_could_be_the_next_addiction_treatment%E2%80%9D\" >&#8220;How a skin graft could be the next addiction treatment&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CHow_a_skin_graft_could_be_the_next_addiction_treatment%E2%80%9D\"><\/span>&#8220;How a skin graft could be the next addiction treatment&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<aside class=\"single__inline-module alignleft\">\n<\/aside>\n<p>A potential new surgical treatment for cocaine and alcohol addiction only goes skin deep, but could leave a long-lasting impact.<\/p>\n<p>Following successful <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/polsky.uchicago.edu\/2022\/01\/10\/crispr-modified-skin-grafts-to-treat-addiction-the-opportunities-are-endless-says-ceo\/\">experiments reported<\/a> earlier this year <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41380-021-01043-y\">in the journal Nature<\/a>, researchers at the University of Chicago hope to launch human clinical trials of a new way to combat addiction through a genetically engineered skin graft.<\/p>\n<p>University researchers\u00a0Xiaoyang Wu and Ming Xu have seen mice hooked on cocaine and alcohol turn up their whiskers at the stuff after receiving a graft of genetically altered human skin.<\/p>\n<p>By taking just a thumbnail size piece of skin from the patient, scientists can now use the gene-editing tool CRISPR to edit and grow new and improved cells, designed to regulate dopamine spikes against alcohol cravings or produce an enzyme that blocks the effects of cocaine, then reattach to the patient. <\/p>\n<p>Mice forced to drink water laced with cocaine and alcohol were found to ignore their spiked options in favor of plain water after receiving a skin graft of altered human cells.  <\/p>\n<p>\u201cThe relapse rate is extremely high in the untreated mouse population, where it\u2019s extremely low in the treated population because they have less of the craving,\u201d Ryan Meyers, an MBA candidate at the University of Chicago, told the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.chicagotribune.com\/news\/ct-cocaine-alcohol-addiction-skin-graft-chicago-20220315-4vrokl3amvccvekggj7ortmxd4-story.html\">Chicago Tribune<\/a>. \u201cThey\u2019re not necessarily going to actually look for it.\u201d<\/p>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"682\" src=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-02.jpg?quality=90&amp;strip=all&amp;w=1024\" alt=\"diagram of skin graft sampling\" class=\"wp-image-21538014\" srcset=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-02.jpg?quality=90&amp;strip=all&amp;w=1535 1536w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-02.jpg?quality=90&amp;strip=all 1024w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-02.jpg?quality=90&amp;strip=all&amp;w=512 512w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\"\/><figcaption>A piece of skin about the size of a thumbnail would be harvested from the patient, as illustrated in a video by AddGraft Therapeutics.<\/figcaption><figcaption><span class=\"credit\">Courtesy of AddGraft<\/span><\/figcaption><\/figure>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"682\" src=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-04.jpg?quality=90&amp;strip=all&amp;w=1024\" alt=\"diagram of skin graft\" class=\"wp-image-21538018\" srcset=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-04.jpg?quality=90&amp;strip=all&amp;w=1535 1536w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-04.jpg?quality=90&amp;strip=all 1024w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addgraft-video-04.jpg?quality=90&amp;strip=all&amp;w=512 512w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\"\/><figcaption>The skin would be genetically altered to dull the effects of addictive substances and transplanted back onto the patient.<\/figcaption><figcaption><span class=\"credit\">Courtesy of AddGraft<\/span><\/figcaption><\/figure>\n<p>In humans, a small piece of harvested skin would be grown to the size of two credit cards, then transplanted back onto their body. The graft would rewrite how their bodies respond to those substances.<\/p>\n<aside class=\"single__inline-module alignright\">\n    <\/aside>\n<p>Wu told the Chicago Tribune that he and Xu are seeking <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roval from the Food and Drug Administration to try their hand at human skin. From there, it could take five years or more for the treatment to reach the public. The researchers also hope such a procedure could later be used to treat other diseases and disorders.<\/p>\n<p>It holds promise for addicts with a history of relapse.<\/p>\n<p>\u201cWe\u2019ve gotten some heartbreaking emails from individuals asking to be in clinical trials,\u201d said Meyers, a former health care consultant who formed the company AddGraft Therapeutics with Wu and Xu, according to the Chicago Tribune.<\/p>\n<p>Michael Darcy, former CEO of Gateway Foundation rehab centers and now an unpaid member of AddGraft\u2019s board of advisers, hopes it could help those who struggle to stick with other behavioral or pharmaceutical regimen to stave off cravings. <\/p>\n<p>\u201cThe AddGraft is just another option for people,\u201d he said. \u201cI don\u2019t think AddGraft is going to replace medication-assisted treatment or outpatient treatment or residential treatment, but it does add another possibility.\u201d\n                        <\/p><\/div>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">News<\/a> articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/news\/\" target=\"_blank\" rel=\"noopener\">News category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/nypost.com\/2022\/03\/15\/how-a-skin-graft-could-be-the-next-addiction-treatment\/\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;How a skin graft could be the next addiction treatment&#8221; A potential new surgical treatment for cocaine and alcohol addiction only goes skin deep, but could leave a long-lasting impact. Following successful experiments reported earlier this year in the journal Nature, researchers at the University of Chicago hope to launch human clinical trials of a&#8230;<\/p>\n","protected":false},"author":1,"featured_media":416737,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/addiction.jpg?quality=90&strip=all&w=1024","fifu_image_alt":"","footnotes":""},"categories":[70897],"tags":[126801,71059,70510,73401,94113],"class_list":["post-416736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-3-15-22","tag-addiction","tag-genetics","tag-medical-breakthroughs","tag-substance-abuse"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/416736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=416736"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/416736\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/416737"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=416736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=416736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=416736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}