{"id":417472,"date":"2022-03-17T15:20:29","date_gmt":"2022-03-17T12:20:29","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/how-spider-silk-could-one-day-be-used-in-cancer-treatment\/"},"modified":"2022-03-17T15:20:29","modified_gmt":"2022-03-17T12:20:29","slug":"how-spider-silk-could-one-day-be-used-in-cancer-treatment","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/how-spider-silk-could-one-day-be-used-in-cancer-treatment\/","title":{"rendered":"#How spider silk could one day be used in cancer treatment"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3df948e7f6f\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3df948e7f6f\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/how-spider-silk-could-one-day-be-used-in-cancer-treatment\/#%E2%80%9CHow_spider_silk_could_one_day_be_used_in_cancer_treatment%E2%80%9D\" >&#8220;How spider silk could one day be used in cancer treatment&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CHow_spider_silk_could_one_day_be_used_in_cancer_treatment%E2%80%9D\"><\/span>&#8220;How spider silk could one day be used in cancer treatment&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/how-spider-silk-could.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/how-spider-silk-could.jpg\" data-sub-html=\"Credit: Vadym Lesyk\/Shutterstock\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/how-spider-silk-could.jpg\" alt=\"How spider silk could one day be used in cancer treatment \u2013 new research\" title=\"Credit: Vadym Lesyk\/Shutterstock\" width=\"800\" height=\"394\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Vadym Lesyk\/Shutterstock<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Cancer is simultaneously one of the most common and devastating diseases in our society. So working out new ways to treat it is an enduring scientific challenge.<\/p>\n<section class=\"article-banner first-banner ads-336x280\">\n         <!-- \/4988204\/Phys_Story_InText_Box --><\/p>\n<\/section>\n<p>A protein called p53 plays <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/ki.se\/en\/research\/p53-the-guardian-of-the-genome\">a key role<\/a> in the body&#8217;s immune response to cancer, and therefore makes an interesting target for cancer treatment. Specifically, our bodies rely on p53 to prevent cancer cells from growing and dividing uncontrollably.<\/p>\n<p>P53 has been called the &#8220;guardian of the genome&#8221; because it can stop cells with DNA damage turning into cancer cells. Essentially, it shuts down the cell if it detects any damage that could cause cells to grow into tumors.<\/p>\n<p>In up to <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/cdd2017180\">60% of all cancers<\/a>, p53 is missing or damaged, making this the most common feature shared across human cancers. So introducing intact p53 protein into cancer cells would be an elegant way of treating the disease.<\/p>\n<p>This is more difficult than it sounds, though. P53 is a relatively large and floppy protein, which means our cells do not produce large amounts of it, it can easily clump together and stop working, and it is quickly broken down once it has been made.<\/p>\n<p>To find a possible solution to this problem, we looked at how nature deals with similar proteins. Somewhat unexpectedly, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/nchembio.1789\">spidroins<\/a>, the proteins that spiders spin into silk, are a bit like p53. They, too, are large, floppy, and easily clump together. But unlike p53, they are c<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ed by a small, compact part (called a domain) that is very stable and can easily be made by the cellular protein production machinery.<\/p>\n<p>In <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.cell.com\/structure\/fulltext\/S0969-2126(22)00049-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0969212622000491%3Fshowall%3Dtrue\">our study<\/a>, which has recently been published in the journal <i>Structure<\/i>, we attached a small section of a spider silk protein\u2014a domain\u2014onto the human p53 protein. When we introduced this &#8220;fusion protein&#8221; to cells in the lab, we found that the cells produced it in very large amounts.<\/p>\n<p>To understand why, we analyzed the protein with electron microscopy, computer simulations, nuclear magnetic resonance, and mass spectrometry. These experiments tell us where the different parts of the protein are located, and how they work together, like parts of a robot. <\/p>\n<p>It turned out that the floppiest part of the p53 protein was wrapped around the spider silk domain like a thread around a spindle. By &#8220;winding up&#8221; the protein like that, the spider silk domain pulled it out from the cellular production machinery, and as a result, more protein was produced.<\/p>\n<p>To test if the spider silk-p53 protein is active, we put it into cancer cells that contain so-called &#8220;reporter genes,&#8221; which cause the cell to light up if p53 turns on genes that make the cell stop growing. To our surprise, the fusion protein gave a stronger response than normal p53, which means that we could in principle use the spider silk domain to increase the ability of p53 to shut down cancer cells.<\/p>\n<p><b>What now?<\/b><\/p>\n<p>None of our findings so far amount to a new cancer therapy. But they do open up new possibilities: we could use this knowledge to design new protein domains that make p53 less floppy and easier to produce.<\/p>\n<p>If we deliver the RNA, the genetic &#8220;blueprint&#8221; for how to make p53, into cells, we could include modified spider silk domains to increase the cells&#8217; ability to make the protein. <\/p>\n<p>As next steps, we will test how well healthy human cells tolerate the spider silk proteins, and whether this addition extends the lifetime of the p53 protein inside the cells.<\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            Spider silk could stabilize cancer-suppressing protein\n                                        <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    The Conversation<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/theconversation.com\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p class=\"article-main__note mt-4\">\n                                                This article is republished from <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\">The Conversation<\/a> under a Creative Commons license. Read the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/how-spider-silk-could-one-day-be-used-in-cancer-treatment-new-research-179230\">original article<\/a>.<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/counter.theconversation.com\/content\/179230\/count.gif?distributor=republish-lightbox-advanced\" alt=\"The Conversation\" width=\"1\" height=\"1\"\/><\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 How spider silk could one day be used in cancer treatment (2022, March 17)<br \/>\n                                                 retrieved 17 March 2022<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-spider-silk-day-cancer-treatment.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/phys.org\/news\/2022-03-spider-silk-day-cancer-treatment.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;How spider silk could one day be used in cancer treatment&#8221; Credit: Vadym Lesyk\/Shutterstock Cancer is simultaneously one of the most common and devastating diseases in our society. So working out new ways to treat it is an enduring scientific challenge. A protein called p53 plays a key role in the body&#8217;s immune response to&#8230;<\/p>\n","protected":false},"author":1,"featured_media":417473,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/how-spider-silk-could.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-417472","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/417472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=417472"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/417472\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/417473"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=417472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=417472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=417472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}