{"id":418340,"date":"2022-03-19T00:24:31","date_gmt":"2022-03-18T21:24:31","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/a-dimmer-switch-for-human-brain-cell-growth\/"},"modified":"2022-03-19T00:24:31","modified_gmt":"2022-03-18T21:24:31","slug":"a-dimmer-switch-for-human-brain-cell-growth","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/a-dimmer-switch-for-human-brain-cell-growth\/","title":{"rendered":"#A dimmer switch for human brain cell growth"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3373958552a\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3373958552a\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/a-dimmer-switch-for-human-brain-cell-growth\/#%E2%80%9CA_dimmer_switch_for_human_brain_cell_growth%E2%80%9D\" >&#8220;A dimmer switch for human brain cell growth&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CA_dimmer_switch_for_human_brain_cell_growth%E2%80%9D\"><\/span>&#8220;A dimmer switch for human brain cell growth&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/a-dimmer-switch-for-hu.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/a-dimmer-switch-for-hu.jpg\" data-sub-html=\"Human neurons derived from urine allow students in the Ernst lab to model neurodevelopmental disease such as FOXG1 syndrome. This image shows a large cluster of neuronal cells that are colored for genes known to be expressed in brain cells. Once created, these neurons can be used to study developmental processes, test drugs, or genetically engineer changes to gene products that may be deficient in diseases such as FOXG1 syndrome. Credit: Nuwan Hettige\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/a-dimmer-switch-for-hu.jpg\" alt=\"A dimmer switch for human brain cell growth\" title=\"Human neurons derived from urine allow students in the Ernst lab to model neurodevelopmental disease such as FOXG1 syndrome. This image shows a large cluster of neuronal cells that are colored for genes known to be expressed in brain cells. Once created, these neurons can be used to study developmental processes, test drugs, or genetically engineer changes to gene products that may be deficient in diseases such as FOXG1 syndrome. Credit: Nuwan Hettige\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Human neurons derived from urine allow students in the Ernst lab to model neurodevelopmental disease such as FOXG1 syndrome. This image shows a large cluster of neuronal cells that are colored for genes known to be expressed in brain cells. Once created, these neurons can be used to study developmental processes, test drugs, or genetically engineer changes to gene products that may be deficient in diseases such as FOXG1 syndrome. Credit: Nuwan Hettige<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Controlling how cells grow is fundamental to ensuring proper brain development and stopping aggressive brain tumors. The network of molecules that control brain cell growth is thought to be complex and vast, but now McGill University researchers provide striking evidence of a single gene that can, by itself, control brain cell growth in humans.<\/p>\n<p>                                                                                                                        In a paper published recently in <i>Stem Cell<\/i> reports, Carl Ernst, an Associate Professor in the Department of Psychiatry at McGill University and his team have shown that the loss of the FOXG1 gene in brain cells from patients with severe microcephaly\u2014a disease where the brain does not grow large enough\u2014reduces brain cell growth.  Using genetic engineering, they turned on FOXG1 in cells from a microcephaly patient to different levels and showed corresponding increases in brain cell growth.  They have uncovered a remarkable dimmer switch to turn brain cell growth up or down.<\/p>\n<p>Their research indicates that a single gene could potentially be targeted to stop brain tumor cells from growing. Or that future gene therapy might allow this same gene to be turned up in patients with microcephaly or other neurodevelopmental disorders.<\/p>\n<p>&#8220;FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells&#8221;  by Nuwan C. Hettige et al. was published in <i>Stem Cell Reports<\/i>.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Brain cancer study reveals therapy clues\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Nuwan C. Hettige et al, FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells, <i>Stem Cell Reports<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"http:\/\/dx.doi.org\/10.1016\/j.stemcr.2022.01.010\">DOI: 10.1016\/j.stemcr.2022.01.010<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    McGill University<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.mcgill.ca\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 A dimmer switch for human brain cell growth (2022, March 18)<br \/>\n                                                 retrieved 18 March 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-dimmer-human-brain-cell-growth.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2022-03-dimmer-human-brain-cell-growth.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;A dimmer switch for human brain cell growth&#8221; Human neurons derived from urine allow students in the Ernst lab to model neurodevelopmental disease such as FOXG1 syndrome. This image shows a large cluster of neuronal cells that are colored for genes known to be expressed in brain cells. Once created, these neurons can be used&#8230;<\/p>\n","protected":false},"author":1,"featured_media":418341,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/a-dimmer-switch-for-hu.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-418340","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/418340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=418340"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/418340\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/418341"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=418340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=418340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=418340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}