{"id":421267,"date":"2022-03-24T23:39:57","date_gmt":"2022-03-24T20:39:57","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/cells-dancing-harmonic-duets-could-enable-personalized-cancer-therapies\/"},"modified":"2022-03-24T23:39:57","modified_gmt":"2022-03-24T20:39:57","slug":"cells-dancing-harmonic-duets-could-enable-personalized-cancer-therapies","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/cells-dancing-harmonic-duets-could-enable-personalized-cancer-therapies\/","title":{"rendered":"#Cells dancing harmonic duets could enable personalized cancer therapies"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a27e2a95f5a2\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a27e2a95f5a2\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/cells-dancing-harmonic-duets-could-enable-personalized-cancer-therapies\/#%E2%80%9CCells_dancing_harmonic_duets_could_enable_personalized_cancer_therapies%E2%80%9D\" >&#8220;Cells dancing harmonic duets could enable personalized cancer therapies&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CCells_dancing_harmonic_duets_could_enable_personalized_cancer_therapies%E2%80%9D\"><\/span>&#8220;Cells dancing harmonic duets could enable personalized cancer therapies&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2021\/egg-cells.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2021\/egg-cells.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2021\/egg-cells.jpg\" alt=\"egg cells\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Mechanical engineers at Duke University are using two electronic &#8220;voices&#8221; singing a harmonic duet to control suspended particles and cells in new and valuable ways. Their prototype device can form and rotate a single-layer crystal from a group of particles, create arbitrary shapes with a given number of particles, and move pairs of biological cells together and apart again hundreds of times.<\/p>\n<section class=\"article-banner first-banner ads-336x280\">\n         <!-- \/4988204\/Phys_Story_InText_Box --><\/p>\n<\/section>\n<p>These abilities could serve a wide variety of fields, such as materials <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a>, soft condensed-matter physics, biophysics, life science and medicine.<\/p>\n<p>For example, the researchers have shown that the device can selectively pair two individual cells and measure their adhesion forces\u2014a feat that doctors could use to determine treatment for individual cancer patients. Because of the dexterity and gentleness of the acoustic device, the researchers have named it the HANDS platform. (Harmonic Acoustics for Non-contact, Dynamic, Selective particle manipulation.)<\/p>\n<p>The results <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ear online on March 24 in the journal <i>Nature Materials<\/i>.<\/p>\n<p>&#8220;The separation of paired particles or cells has been a major target in the field of acoustic manipulation for many years,&#8221; said Tony Jun Huang, the William Bevan Distinguished Professor of Mechanical Engineering and Materials Science at Duke. &#8220;Our HANDS platform is the first method of separating paired objects, which provides a way into cell-cell interaction studies that are needed extensively in biophysics studies and drug discovery.&#8221;<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\">\n    <meta itemprop=\"name\" content=\"Cells dancing harmonic duets could enable personalized cancer therapies\"\/><br \/>\n    <meta itemprop=\"url\" content=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic.mp4\"\/><br \/>\n    <meta itemprop=\"description\" content=\"A new sound-based technology developed at Duke University can pair individual cells together and pull them back apart hundreds of times over. Credit: Tony Jun Huang Lab, Duke University\"\/><br \/>\n    <meta itemprop=\"uploadDate\" content=\"2022-03-24T16:22:18-04:00\"\/><br \/>\n        <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/scx1.b-cdn.net\/gfx\/video_tmb\/2022\/cells-dancing-harmonic.mp4.jpg\"\/><br \/>\n    <meta itemprop=\"contentUrl\" content=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic.mp4\"\/><br \/>\n            <video class=\"embed-responsive embed-responsive-16by9\" id=\"jwVID68797\" controls=\"\" poster=\"https:\/\/scx1.b-cdn.net\/gfx\/video_tmb\/2022\/cells-dancing-harmonic.mp4.jpg\"><source src=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic.mp4\" type=\"video\/mp4\"><\/source><\/video><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">A new sound-based <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> developed at Duke University can pair individual cells together and pull them back apart hundreds of times over. Credit: Tony Jun Huang Lab, Duke University<\/figcaption><\/figure>\n<p>Acoustic tweezers are a rapidly developing field that uses various physical phenomena of sound waves to gently manipulate particles or cells suspended in liquids without touching them. Some examples pinch particles between two sound waves and adjust the waves&#8217; phase or origination point to move them. Others create patterns by combining two static standing sound waves together to separate particles into different formations, such as a grid.<\/p>\n<p>Now, researchers have added a new layer of complexity to these devices by introducing piezoelectric melodies and harmonies into the setup. Where previous devices create static standing waves, the HANDS platform prototype uses a function generator to create complex standing waves that change rapidly. One could think of it as though rather than the machines singing a single note, they&#8217;re now hitting the rapid highs and lows of a complicated opera with two singers.<\/p>\n<p>The new device works by placing sound-creating transducers on each side of a small square chamber filled with liquid. These four transducers work in step with those directly across from them, forming two pairs. One creates patterns in the chamber horizontally and the other vertically. The interaction of these two complex, quickly changing sound wave patterns creates dynamic abilities never before demonstrated within the field.<\/p>\n<p>&#8220;I simulated how these waves might combine to manipulate the particles in the chamber and then ran experiments to see actual results,&#8221; said Shujie Yang, a postdoctoral associate in the Huang laboratory. &#8220;It took a long time and many trials, but finally the simulations became good enough to start matching the results. And once the simulations were accurate, I could begin predicting new abilities.&#8221;<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\">\n    <meta itemprop=\"name\" content=\"Cells dancing harmonic duets could enable personalized cancer therapies\"\/><br \/>\n    <meta itemprop=\"url\" content=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic-1.mp4\"\/><br \/>\n    <meta itemprop=\"description\" content=\"A new sound-based technology developed at Duke University can selectively choose two individual cells near one another to pair and pull apart again\u2014a feat that doctors could use to determine the best treatment for individual cancer patients. Credit: Tony Jun Huang Lab, Duke University\"\/><br \/>\n    <meta itemprop=\"uploadDate\" content=\"2022-03-24T16:22:21-04:00\"\/><br \/>\n        <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/scx1.b-cdn.net\/gfx\/video_tmb\/2022\/cells-dancing-harmonic-1.mp4.jpg\"\/><br \/>\n    <meta itemprop=\"contentUrl\" content=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic-1.mp4\"\/><br \/>\n            <video class=\"embed-responsive embed-responsive-16by9\" id=\"jwVID68798\" controls=\"\" poster=\"https:\/\/scx1.b-cdn.net\/gfx\/video_tmb\/2022\/cells-dancing-harmonic-1.mp4.jpg\"><source src=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic-1.mp4\" type=\"video\/mp4\"><\/source><\/video><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">A new sound-based technology developed at Duke University can selectively choose two individual cells near one another to pair and pull apart again\u2014a feat that doctors could use to determine the best treatment for individual cancer patients. Credit: Tony Jun Huang Lab, Duke University<\/figcaption><\/figure>\n<p>In the paper, Yang demonstrates several novel abilities of the harmonic duet acoustic tweezers. In one experiment, he shows that the HANDS platform can flatten and pattern a 3D cluster of 24 particles into a crystalline structure. It can spin these flat formations like a plate on a fingertip.<\/p>\n<p>Moving to individual particle manipulation, the paper demonstrates particles coaxed into three different formations bearing a striking resemblance to the letters O, D and K. The device then pairs together dozens of single particles like teenagers at a school dance and shows that it can pull each pair apart and put them back together again more than a thousand times.<\/p>\n<p>In the final demonstration, Yang shows that the device can select a single pair of cells out of a lineup, push them together and pull them back apart. He then uses this ability to measure the adhesion forces at work between two cells touching one another.<\/p>\n<p>According to the researchers, this is the most exciting ability of the HANDS platform, as it could allow detailed tests for personalized medicine.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\">\n    <meta itemprop=\"name\" content=\"Cells dancing harmonic duets could enable personalized cancer therapies\"\/><br \/>\n    <meta itemprop=\"url\" content=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic-2.mp4\"\/><br \/>\n    <meta itemprop=\"description\" content=\"A new sound-based technology developed at Duke University can form an ordered, single-layer crystalline structure out of a group of particles or cells. Credit: Tony Jun Huang Lab, Duke University\"\/><br \/>\n    <meta itemprop=\"uploadDate\" content=\"2022-03-24T16:22:25-04:00\"\/><br \/>\n        <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/scx1.b-cdn.net\/gfx\/video_tmb\/2022\/cells-dancing-harmonic-2.mp4.jpg\"\/><br \/>\n    <meta itemprop=\"contentUrl\" content=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic-2.mp4\"\/><br \/>\n            <video class=\"embed-responsive embed-responsive-16by9\" id=\"jwVID68799\" controls=\"\" poster=\"https:\/\/scx1.b-cdn.net\/gfx\/video_tmb\/2022\/cells-dancing-harmonic-2.mp4.jpg\"><source src=\"https:\/\/scx2.b-cdn.net\/gfx\/video\/2022\/cells-dancing-harmonic-2.mp4\" type=\"video\/mp4\"><\/source><\/video><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">A new sound-based technology developed at Duke University can form an ordered, single-layer crystalline structure out of a group of particles or cells. Credit: Tony Jun Huang Lab, Duke University<\/figcaption><\/figure>\n<p>&#8220;I am thrilled about the capabilities of this platform, which is as gentle as a mother&#8217;s hands,&#8221; said Luke Lee, professor of medicine at Harvard Medical School, who is a co-leader of the research. &#8220;Gentle and sensitive mother&#8217;s hands allow us to establish the foundation of quantitative cell biology and translational precision medicine.&#8221;<\/p>\n<p>&#8220;For example, we can systematically study T-cell interactions with cancer cells in a high-throughput manner and obtain precision cell-cell interaction forces,&#8221; Lee said. &#8220;This could help doctors find the most effective and specific cell therapy for patients as personalized precision medicine.&#8221;<\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            Sound waves replace human hands in petri dish experiments\n                                        <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Luke Lee, Harmonic acoustics for dynamic and selective particle manipulation, <i>Nature Materials<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"http:\/\/dx.doi.org\/10.1038\/s41563-022-01210-8\">DOI: 10.1038\/s41563-022-01210-8<\/a>. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41563-022-01210-8\">www.nature.com\/articles\/s41563-022-01210-8<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Duke University<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.duke.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Cells dancing harmonic duets could enable personalized cancer therapies (2022, March 24)<br \/>\n                                                 retrieved 25 March 2022<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-cells-harmonic-duets-enable-personalized.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/phys.org\/news\/2022-03-cells-harmonic-duets-enable-personalized.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Cells dancing harmonic duets could enable personalized cancer therapies&#8221; Credit: Pixabay\/CC0 Public Domain Mechanical engineers at Duke University are using two electronic &#8220;voices&#8221; singing a harmonic duet to control suspended particles and cells in new and valuable ways. Their prototype device can form and rotate a single-layer crystal from a group of particles, create arbitrary&#8230;<\/p>\n","protected":false},"author":1,"featured_media":421268,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2021\/egg-cells.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-421267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/421267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=421267"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/421267\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/421268"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=421267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=421267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=421267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}