{"id":421705,"date":"2022-03-26T00:55:23","date_gmt":"2022-03-25T21:55:23","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/new-pathway-for-dna-transfer-discovered-in-tumor-microenvironment\/"},"modified":"2022-03-26T00:55:23","modified_gmt":"2022-03-25T21:55:23","slug":"new-pathway-for-dna-transfer-discovered-in-tumor-microenvironment","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/new-pathway-for-dna-transfer-discovered-in-tumor-microenvironment\/","title":{"rendered":"#New pathway for DNA transfer discovered in tumor microenvironment"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a2cf1522fc23\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a2cf1522fc23\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/new-pathway-for-dna-transfer-discovered-in-tumor-microenvironment\/#%E2%80%9CNew_pathway_for_DNA_transfer_discovered_in_tumor_microenvironment%E2%80%9D\" >&#8220;New pathway for DNA transfer discovered in tumor microenvironment&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CNew_pathway_for_DNA_transfer_discovered_in_tumor_microenvironment%E2%80%9D\"><\/span>&#8220;New pathway for DNA transfer discovered in tumor microenvironment&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2021\/dna-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2021\/dna-2.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2021\/dna-2.jpg\" alt=\"dna\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>University of Notre Dame researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.<\/p>\n<section class=\"article-banner first-banner ads-336x280\">\n         <!-- \/4988204\/Phys_Story_InText_Box --><\/p>\n<\/section>\n<p>In their latest study, published in <i>Cell Reports<\/i>, Crislyn D&#8217;Souza-Schorey, the Morris Pollard Professor in the Department of Biological <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s, and collaborators discovered that DNA &#8220;cargo&#8221; is transported in small informational sacs called extracellular microvesicles. Their study is a continuation of work her lab has undertaken to further understand the sharing of information between cells.<\/p>\n<p>&#8220;We&#8217;ve shown that DNA present in these microvesicles is related to metastasis, so now we have a great platform to assess for genetic aberrations,&#8221; said D&#8217;Souza-Schorey, who is also affiliated with the Berthiaume Institute for Precision Health, the Boler-Parseghian Center for Rare and Neglected Diseases and the Harper Cancer Research Institute.<\/p>\n<p>Cancer cells, unlike normal cells, are often filled with cytosolic DNA, which is DNA found in the jelly-like fluid outside of the cell&#8217;s nucleus. This DNA can be derived from multiple sources, but recent evidence suggests that chromosomal instability is a primary source of cytosolic DNA in tumor cells. <\/p>\n<p>The research team used a cell model from a male cancer patient to show how Y-chromosomal DNA\u2014present in the cytosol due to chromosomal instability\u2014is carried by extracellular vesicles and transferred to a female mammary epithelial cell line.<\/p>\n<p>&#8220;These female cells do not have Y-chromosomal DNA present without exposure to the male microvesicles,&#8221; said James Clancy, research assistant professor of biological sciences, who is the first author on the paper. &#8220;This is an accessible way to show people that the DNA was transferred, making it easier to prove this form of communication.&#8221;<\/p>\n<p>The researchers demonstrated that cytosolic DNA is moved to microvesicles alongside an enzyme, cGAS, which was discovered in part because of its role during the immune response to bacterial and viral infections. Scientists have increasingly recognized that cGAS may play a part in tumor progression, and this new study delineated a way the DNA is modified to aid that progression. <\/p>\n<p>Work <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/medicalxpress.com\/news\/2019-07-deciphers-packaging-tumor-cargo-cancers.html\">published by D&#8217;Souza-Schorey&#8217;s lab in 2019<\/a> in <i>Nature Cell Biology<\/i> described how microRNA within tumor cells is moved to microvesicles just beginning to form at the cell periphery. Once shed, these vesicles are taken up by non-tumor cells in the microenvironment. Microvesicles can also be found circulating through the body in fluids like blood and urine, and can be used as biomarkers that point to the presence of cancer.<\/p>\n<p>While microRNA can affect protein expression more quickly than DNA, the researchers were interested in the DNA content as it is the actual part of a person&#8217;s genome, including any tumor-associated mutations, Clancy said. It was also more difficult to prove that DNA has moved from one cell to another.<\/p>\n<p>The lab&#8217;s continued foundational research in this area may lead to early detection of different types of tumors.<\/p>\n<p>In addition to D&#8217;Souza-Schorey and Clancy, others who worked on the study include Colin Sheehan, class of &#8217;19, and Alex C. Boomgarden, a fourth-year doctoral student at Notre Dame and recipient of a Berthiaume Institute for Precision Health predoctoral fellowship. Sheehan is now pursuing his doctoral degree at the University of Chicago. The study was supported in part by the National Cancer Institute and the Boler Family Foundation.<\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/medicalxpress.com\/news\/2019-07-deciphers-packaging-tumor-cargo-cancers.html\">Study deciphers packaging of tumor &#8216;cargo,&#8217; leading to better understanding of how cancers spread<\/a>\n                                        <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                James W. Clancy et al, Recruitment of DNA to tumor-derived microvesicles, <i>Cell Reports<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"http:\/\/dx.doi.org\/10.1016\/j.celrep.2022.110443\">DOI: 10.1016\/j.celrep.2022.110443<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of Notre Dame<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/nd.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 New pathway for DNA transfer discovered in tumor microenvironment (2022, March 25)<br \/>\n                                                 retrieved 25 March 2022<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-pathway-dna-tumor-microenvironment.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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In their latest study, published in Cell Reports, Crislyn D&#8217;Souza-Schorey, the Morris Pollard Professor in the Department of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":421706,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2021\/dna-2.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-421705","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/421705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=421705"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/421705\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/421706"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=421705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=421705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=421705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}