{"id":422031,"date":"2022-03-26T17:30:01","date_gmt":"2022-03-26T14:30:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/male-contraceptive-pill-found-99-effective-in-mice\/"},"modified":"2022-03-26T17:30:01","modified_gmt":"2022-03-26T14:30:01","slug":"male-contraceptive-pill-found-99-effective-in-mice","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/male-contraceptive-pill-found-99-effective-in-mice\/","title":{"rendered":"#Male contraceptive pill found 99% effective in mice"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a35fe5fcf383\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a35fe5fcf383\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/male-contraceptive-pill-found-99-effective-in-mice\/#%E2%80%9CMale_contraceptive_pill_found_99_effective_in_mice%E2%80%9D\" >&#8220;Male contraceptive pill found 99% effective in mice&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CMale_contraceptive_pill_found_99_effective_in_mice%E2%80%9D\"><\/span>&#8220;Male contraceptive pill found 99% effective in mice&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/this-picture-taken-on-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/this-picture-taken-on-2.jpg\" data-sub-html=\"This picture taken on June 1, 2021 shows a mouse feeding on grains in a wheat hold on Col Tink's farmland in the New South Wales' agricultural hub of Dubbo.\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/this-picture-taken-on-2.jpg\" alt=\"This picture taken on June 1, 2021 shows a mouse feeding on grains in a wheat hold on Col Tink's farmland in the New South Wales\" title=\"This picture taken on June 1, 2021 shows a mouse feeding on grains in a wheat hold on Col Tink's farmland in the New South Wales' agricultural hub of Dubbo.\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                This picture taken on June 1, 2021 shows a mouse feeding on grains in a wheat hold on Col Tink&#8217;s farmland in the New South Wales&#8217; agricultural hub of Dubbo.<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A team of scientists said Wednesday they had developed a male oral contraceptive that was 99 percent effective in mice and didn&#8217;t cause observable side effects, with the drug expected to enter human trials by the end of this year.\n                                                <\/p>\n<p>                                                                                The findings will be presented at the American Chemical Society&#8217;s spring meeting, and mark a key step towards expanding birth control options\u2014as well as responsibilities\u2014for men.<\/p>\n<p>Ever since the female birth control pill was first <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roved in the 1960s, researchers have been interested in a male equivalent, Md Abdullah Al Noman, a graduate student at the University of Minnesota who will present the work, told AFP.<\/p>\n<p>&#8220;Multiple studies showed that men are interested in sharing the responsibility of birth control with their partners,&#8221; he said\u2014but until now, there have been only two effective options available: condoms or vasectomies. <\/p>\n<p>Vasectomy reversal surgery is expensive and not always successful.<\/p>\n<p>The female pill uses hormones to disrupt the menstrual cycle, and historic efforts to develop a male equivalent targeted the male sex hormone testosterone.<\/p>\n<p>The problem with this approach, however, was that it caused side effects such as weight gain, depression and increased levels of a cholesterol known as low-density lipoprotein, which increases heart disease risks.<\/p>\n<p>The female pill also carries side effects, including blood-clotting risks\u2014but since women face becoming pregnant in the absence of contraception, the risk calculation differs.<\/p>\n<p><b>Non-hormonal<\/b><\/p>\n<p>To develop a non-hormonal drug, Noman, who works in the lab of Professor Gunda Georg, targeted a protein called &#8220;retinoic acid receptor (RAR) alpha.&#8221;<\/p>\n<p>Inside the body, vitamin A is converted into different forms, including retinoic acid, which plays important roles in cell growth, sperm formation, and embryo development.<\/p>\n<p>Retinoic acid needs to interact with RAR-alpha to perform these functions, and lab experiments have shown mice without the gene that creates RAR-alpha are sterile.<\/p>\n<p>For their work, Noman and Georg developed a compound that blocks the action of RAR-alpha. They identified the best molecular structure with the help of a computer model.<\/p>\n<p>&#8220;If we know what the keyhole looks like, then we can make a better key\u2014that&#8217;s where the computational model comes in,&#8221; said Noman.<\/p>\n<p>Their chemical, known as YCT529, was also designed to interact specifically with RAR-alpha, and not two other related receptors RAR-beta and RAR-gamma, in order to minimize potential side effects.<\/p>\n<p><b>Five years to market?<\/b><\/p>\n<p>When administered orally to male mice for four weeks, YCT529 drastically reduced sperm counts and was 99 percent effective in preventing pregnancy in a mating trial.<\/p>\n<p>The researchers monitored weight, appetite and overall activity, finding no apparent adverse impacts, although mice of course can&#8217;t report side effects like headaches or mood changes.<\/p>\n<p>Four to six weeks after they were taken off the drug, the mice could once more sire pups.<\/p>\n<p>The team, which received funding from the National Institutes of Health and the Male Contraceptive Initiative, is working with a company called YourChoice Therapeutics to start human trials by the third or fourth quarter of 2022, said Georg.<\/p>\n<p>&#8220;I&#8217;m optimistic this will move forward quickly,&#8221; she said, envisaging a possible timeline to market in five years or under.<\/p>\n<p>&#8220;There is no guarantee that it will work&#8230;but I would really be surprised if we didn&#8217;t see an effect in humans as well,&#8221; she added.<\/p>\n<p>A persistent question about future male contraceptive pills has been whether women will trust men to use them.<\/p>\n<p>But surveys have shown that most women would in fact have faith in their partners, and significant numbers of men have indicated they would be open to the medication.<\/p>\n<p>&#8220;Male contraceptives will add to the method mix, providing new options that allow men and women to contribute in whatever way they deem appropriate to contraceptive use,&#8221; argues the nonprofit Male Contraceptive Initiative, which engages in fundraising and advocacy.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        A non-hormonal pill could soon expand men&#8217;s birth control options\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<p class=\"article-main__note mt-4\">\n                                                \u00a9 2022 AFP<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Male contraceptive pill found 99% effective in mice (2022, March 26)<br \/>\n                                                 retrieved 26 March 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-male-contraceptive-pill-effective-mice.html<\/p>\n<p>                                            This document is subject to copyright. 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A team of scientists said Wednesday they had developed a male oral contraceptive that was 99 percent&#8230;<\/p>\n","protected":false},"author":1,"featured_media":422032,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/this-picture-taken-on-2.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-422031","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/422031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=422031"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/422031\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/422032"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=422031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=422031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=422031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}