{"id":422827,"date":"2022-03-28T20:10:58","date_gmt":"2022-03-28T17:10:58","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/new-test-predicts-sepsis-soon-after-infection\/"},"modified":"2022-03-28T20:10:58","modified_gmt":"2022-03-28T17:10:58","slug":"new-test-predicts-sepsis-soon-after-infection","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/new-test-predicts-sepsis-soon-after-infection\/","title":{"rendered":"#New test predicts sepsis soon after infection"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3a1c73bbfcf\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3a1c73bbfcf\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/new-test-predicts-sepsis-soon-after-infection\/#%E2%80%9CNew_test_predicts_sepsis_soon_after_infection%E2%80%9D\" >&#8220;New test predicts sepsis soon after infection&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CNew_test_predicts_sepsis_soon_after_infection%E2%80%9D\"><\/span>&#8220;New test predicts sepsis soon after infection&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/clot-buster-1.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/clot-buster-1.jpg\" data-sub-html=\"Bacterial infection results in catastrophic changes in blood proteins that can be used as a platform to develop rapid and easy-to-perform tests to predict sepsis for early intervention. Credit: University of California - Santa Barbara\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/clot-buster-1.jpg\" alt=\"Clot buster\" title=\"Bacterial infection results in catastrophic changes in blood proteins that can be used as a platform to develop rapid and easy-to-perform tests to predict sepsis for early intervention. Credit: University of California - Santa Barbara\" width=\"750\" height=\"456\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Bacterial infection results in catastrophic changes in blood proteins that can be used as a platform to develop rapid and easy-to-perform tests to predict sepsis for early intervention. Credit: University of California &#8211; Santa Barbara<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>In a potential paradigm change for sepsis diagnostics, a new test predicted sepsis soon after infection in mice\u2014well before blood clotting and organ failure\u2014enabling early antibiotic treatment and markedly increased survival. The findings provide a platform to develop rapid and easy-to-perform clinical tests for early sepsis detection and clinical intervention in human patients.\n                                                <\/p>\n<p>                                                                                The collaborative effort by a research team including scientists from UC Santa Barbara, UC San Diego, and Sanford Burnham Prebys Medical Discovery Institute (SBPMDI) is detailed in a new study published in the <i>Lancet<\/i> journal, <i>eBioMedicine<\/i>. The team succeeded in detecting a catastrophic shift in blood protein abundance soon after infection that can predict sepsis well before disease symptoms and organ damage arise.<\/p>\n<p>The project was led by professor Michael Mahan of UC Santa Barbara, along with professors Dzung Le of UC San Diego, and Jeffrey Smith and Jamey Marth of SBPMDI. Additional collaborators include UCSB scientists Douglas Heithoff and Scott Mahan, as well as SBPMDI scientists Genaro Pimienta and Won Ho Yang, and University of Sydney veterinarian scientist John House.<\/p>\n<p>Sepsis is the number one cause of death in U.S. hospitals. In the clinic, sepsis is diagnosed by a symptom-based <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach that may include kidney or liver failure, blood clotting or bleeding\u2014which often occurs well after permanent organ damage. Thus, molecular diagnostics that detect infection at early stages of disease to minimize host injury are sorely needed.<\/p>\n<p>&#8220;The key finding was identifying proteins in the blood that arise very soon after infection\u2014well before overt disease symptoms,&#8221; Mahan explained. &#8220;Early detection is critical for clinical intervention to increase survival in sepsis patients.&#8221;<\/p>\n<p>To carry out the test, a small amount of blood was collected and analyzed for an increase in coagulation proteins that are induced but inactive at early stages of infection. Such detection enabled early antibiotic treatment\u2014well before activated coagulation proteins induced blood clotting\u2014resulting in markedly increased survival in mice. The <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> is open source and freely accessible to all.<\/p>\n<p>The study also demonstrated that antibiotics are less effective after blood proteins increase in response to infection. Treatment failure may be due to host injury triggered by excessive blood clotting, providing insight into why delays in antibiotic treatment in human sepsis are associated with increased risk for death.<\/p>\n<p>&#8220;The future plan is to identify a biopanel of early sepsis blood proteins for incorporation into existing blood tests, enabling sepsis prediction well before excessive blood clotting and permanent organ damage,&#8221; Heithoff explained.<\/p>\n<p>The researchers demonstrated that the changes in blood proteins soon after infection observed in mice were similar to that reported for human sepsis. Thus, they are optimistic that these findings are translatable for the early detection and treatment of sepsis in humans.<\/p>\n<p>&#8220;Currently, one in four patients die of sepsis, with many survivors experiencing lifelong debilitation with cognitive decline,&#8221; Scott Mahan said. &#8220;We hope technologies like this offer new ways of delivering state-of-the-art molecular diagnostics that predict sepsis before permanent injury occurs.&#8221;\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Consumer Health: Sepsis is serious\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Douglas M. Heithoff et al, Coagulation factor protein abundance in the pre-septic state predicts coagulopathic activities that arise during late-stage murine sepsis, <i>eBioMedicine<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1016\/j.ebiom.2022.103965\">DOI: 10.1016\/j.ebiom.2022.103965<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of California &#8211; Santa Barbara<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.ucsb.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 New test predicts sepsis soon after infection (2022, March 28)<br \/>\n                                                 retrieved 28 March 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-sepsis-infection.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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Credit: University of California &#8211; Santa Barbara In a potential paradigm change for sepsis diagnostics, a new test predicted sepsis&#8230;<\/p>\n","protected":false},"author":1,"featured_media":422828,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/clot-buster-1.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-422827","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/422827","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=422827"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/422827\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/422828"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=422827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=422827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=422827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}