{"id":423013,"date":"2022-03-29T00:14:01","date_gmt":"2022-03-28T21:14:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/biochemical-technique-for-finding-small-molecules-discovered-by-researchers\/"},"modified":"2022-03-29T00:14:01","modified_gmt":"2022-03-28T21:14:01","slug":"biochemical-technique-for-finding-small-molecules-discovered-by-researchers","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/biochemical-technique-for-finding-small-molecules-discovered-by-researchers\/","title":{"rendered":"#Biochemical technique for finding small molecules discovered by researchers"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a2924c2d9697\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a2924c2d9697\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/biochemical-technique-for-finding-small-molecules-discovered-by-researchers\/#%E2%80%9CBiochemical_technique_for_finding_small_molecules_discovered_by_researchers%E2%80%9D\" >&#8220;Biochemical technique for finding small molecules discovered by researchers&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CBiochemical_technique_for_finding_small_molecules_discovered_by_researchers%E2%80%9D\"><\/span>&#8220;Biochemical technique for finding small molecules discovered by researchers&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/biochemical-technique.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/biochemical-technique.jpg\" data-sub-html=\"Graphical abstract. Credit: &lt;i&gt;ACS Central Science&lt;\/i&gt; (2022). DOI: 10.1021\/acscentsci.1c01058\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/biochemical-technique.jpg\" alt=\"Biochemical technique for finding small molecules discovered by researchers\" title=\"Graphical abstract. Credit: &lt;i&gt;ACS Central Science&lt;\/i&gt; (2022). DOI: 10.1021\/acscentsci.1c01058\" width=\"500\" height=\"268\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Graphical abstract. Credit: <i>ACS Central <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a><\/i> (2022). DOI: 10.1021\/acscentsci.1c01058<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Lipid rafts, a component of the plasma membranes that surround all cells in the human body, are essential in regulating the membranes&#8217; structure, among other functions. But they are hard to study because traditional biochemical methods tend to destroy them.<\/p>\n<section class=\"article-banner first-banner ads-336x280\">\n         <!-- \/4988204\/Phys_Story_InText_Box --><\/p>\n<\/section>\n<p>Chuck Sanders, associate dean for research, professor of biochemistry and medicine and Aileen M. Lange &amp; Annie Mary Lyle Chair for Cardiovascular Research, and his lab collaborated with corresponding author Anne Kenworthy at the University of Virginia School of Medicine to develop new techniques for discovering the small molecules that regulate lipid rafts. Their article was published in <i>ACS Central Science<\/i> in February 2022. <\/p>\n<p>&#8220;Raft-modulatory small molecules are likely an important part of fundamental biological processes,&#8221; Sanders said. &#8220;Lipid rafts are like a clique at a party\u2014always together. This work describes a way of discovering the small molecules that either &#8216;dissolve&#8217; these molecular cliques or that enhance their formation.&#8221; <\/p>\n<p>Lipid rafts are composed of lipids and proteins that stick together as they move within the plasma membrane, like small rafts in the ocean. They assist in cellular transport, signal transduction and immune system functions. For example, the enzymes responsible for production of the amyloid-beta polypeptide closely associated with Alzheimer&#8217;s disease are thought to reside in lipid rafts.  <\/p>\n<p>So learning more about the molecules that regulate lipid raft function may turn out to be disease therapeutic. In addition to Alzheimer&#8217;s, alterations in lipid rafts have been associated with cancer cells that are resistant to chemotherapy. These molecules will also be important research tools that will better enable investigators to study the roles of rafts in healthy and diseased biological processes. <\/p>\n<p>&#8220;In the short term, the robust methods described in this work should lead to the discovery of small molecule tools that can be used either to enhance or to suppress lipid raft formation in research,&#8221; Sanders said. &#8220;In the long term, we hope some of the molecules discovered will have utility in research, bio<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> and medicine.&#8221;  <\/p>\n<p>The screening technique is up for a patent that will be shared by Vanderbilt and the University of Virginia. The Sanders lab will expand and refine the screening <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach described in this paper.  <\/p>\n<p>&#8220;We are seeking to further this approach to discover small molecules that specifically assist with driving membrane proteins in and out of the lipid rafts,&#8221; Sanders said.<\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/medicalxpress.com\/news\/2018-04-toxin-lipid-rafts.html\">Toxin floats on lipid rafts<\/a>\n                                        <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Nico Fricke et al, High-Content Imaging Platform to Discover Chemical Modulators of Plasma Membrane Rafts, <i>ACS Central Science<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1021\/acscentsci.1c01058\">DOI: 10.1021\/acscentsci.1c01058<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Vanderbilt University<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.vanderbilt.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Biochemical technique for finding small molecules discovered by researchers (2022, March 28)<br \/>\n                                                 retrieved 28 March 2022<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-03-biochemical-technique-small-molecules.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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Credit: ACS Central Science (2022). DOI: 10.1021\/acscentsci.1c01058 Lipid rafts, a component of the plasma membranes that surround all cells in the human body, are essential in regulating the membranes&#8217; structure, among other functions. But they are hard to study because traditional biochemical methods tend&#8230;<\/p>\n","protected":false},"author":1,"featured_media":423014,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/biochemical-technique.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-423013","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/423013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=423013"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/423013\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/423014"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=423013"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=423013"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=423013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}