{"id":424331,"date":"2022-03-30T23:33:42","date_gmt":"2022-03-30T20:33:42","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/boys-whose-dads-took-metformin-likely-to-have-defects-study\/"},"modified":"2022-03-30T23:33:42","modified_gmt":"2022-03-30T20:33:42","slug":"boys-whose-dads-took-metformin-likely-to-have-defects-study","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/boys-whose-dads-took-metformin-likely-to-have-defects-study\/","title":{"rendered":"#Boys whose dads took metformin likely to have defects: study"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a25d9b3be6c1\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a25d9b3be6c1\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/boys-whose-dads-took-metformin-likely-to-have-defects-study\/#%E2%80%9CBoys_whose_dads_took_metformin_likely_to_have_defects_study%E2%80%9D\" >&#8220;Boys whose dads took metformin likely to have defects: study&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CBoys_whose_dads_took_metformin_likely_to_have_defects_study%E2%80%9D\"><\/span>&#8220;Boys whose dads took metformin likely to have defects: study&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<aside class=\"single__inline-module alignleft\">\n<\/aside>\n<p>A popular\u00a0diabetes\u00a0drug\u00a0could be linked to major birth\u00a0defects, according to researchers.\u00a0<\/p>\n<p>In a study from Stanford University, the University of Southern Denmark and Copenhagen University, published Tuesday in the Annals of Internal Medicine, the authors wrote that the offspring of male patients who were taking metformin three months before conception were impacted.\u00a0<\/p>\n<p>Sons born to those men were more than three times as likely to have a genital birth defect as unexposed babies, with metformin associated with a 1.4 times greater risk of birth defects in boys whose fathers were taking it versus those who were not. \u00a0<\/p>\n<p>The mothers in both groups had no history of diabetes or hypertension.<\/p>\n<p>In addition, the fathers who used metformin during sperm development were\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.acpjournals.org\/doi\/10.7326\/M21-4389\">less likely<\/a>\u00a0to have boys than girls compared with the <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/general\/\" data-internallinksmanager029f6b8e52c=\"3\" title=\"General\" target=\"_blank\" rel=\"noopener\">general<\/a> population.<\/p>\n<p>Stanford said in a Monday\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/med.stanford.edu\/news\/all-news\/2022\/03\/birth-defects-diabetes-drug.html\">release<\/a>\u00a0that its conclusions suggest that metformin affects men\u2019s reproductive health in a way that can harm their sons, \u201cthough the mechanisms are still unclear.\u201d<\/p>\n<p>To reach these results, the group used health-registry data from\u00a0Denmark\u00a0that tracked more than 1 million births from 1997 to 2016.\u00a0<\/p>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"684\" src=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/shutterstock_1439349791.jpg?w=1024\" alt=\"A man is treated for diabetes.\" class=\"wp-image-21720170\" srcset=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/shutterstock_1439349791.jpg?quality=75&amp;strip=all&amp;w=2048 2048w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/shutterstock_1439349791.jpg?quality=75&amp;strip=all&amp;w=1536 1536w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/shutterstock_1439349791.jpg?quality=75&amp;strip=all 1024w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/shutterstock_1439349791.jpg?quality=75&amp;strip=all&amp;w=512 512w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\"\/><figcaption>The researchers found that fathers who used metformin during sperm development were less likely to have boys than girls compared with the general population.<\/figcaption><figcaption><span class=\"credit\">Shutterstock<\/span><\/figcaption><\/figure>\n<p>The offspring were considered to be exposed if their father filled one or more pre<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">script<\/a>ions for a diabetes drug during the development of fertilizing sperm, and sex and frequencies of major birth defects were compared across drugs, times of exposure and siblings.<\/p>\n<p>Of the more than 1.1 million babies included in the study,\u00a03.3% had at least one major birth defect and 51.4% were boys.\u00a0<\/p>\n<p>Among the 1,451 babies exposed to metformin, 49.4% were male and the rate of birth defects was 5.2%.\u00a0<\/p>\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\">\n<div class=\"wp-block-embed__wrapper\">\n<div class=\"embed-wrapper twitter\">\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\">\n<p lang=\"en\" dir=\"ltr\">Boys were more likely to be born with genital birth defects if their fathers took the commonly prescribed diabetes drug metformin in the three months before conception, according to a new study. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/t.co\/d9ibThMg2b\">https:\/\/t.co\/d9ibThMg2b<\/a><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/twitter.com\/hashtag\/Diabetes?src=hash&amp;ref_src=twsrc%5Etfw\">#Diabetes<\/a> <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/twitter.com\/hashtag\/MedTwitter?src=hash&amp;ref_src=twsrc%5Etfw\">#MedTwitter<\/a><\/p>\n<p>\u2014 Stanford Medicine (@StanfordMed) <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/twitter.com\/StanfordMed\/status\/1508906860828663815?ref_src=twsrc%5Etfw\">March 29, 2022<\/a><\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/figure>\n<p>Stanford explained that the rates mean metformin use may account for two additional babies born with birth defects every year.<\/p>\n<p>The college noted that the oral treatment is increasingly popular for Type 2 diabetes, but is known to have effects on the reproductive system.<\/p>\n<aside class=\"single__inline-module alignright\">\n    <\/aside>\n<p>The researchers also compared exposure to metformin with exposure to two other common diabetes drugs, insulin and sulfonylureas.<\/p>\n<p>Exposure to insulin did not affect the rate of birth defects or sex ratio; exposure to sulfonylureas showed numbers trending in the same direction as metformin exposure, but they lacked a consistent pattern.<\/p>\n<p>Limitations to the study include that information on underlying disease status was limited, as well as whether fathers took the drug as prescribed.\u00a0<\/p>\n<p>The authors called for further research that clarifies the causation of these defects.<\/p>\n<p>\u201cI think that it\u2019s a single study, so it\u2019s hard to change clinical practice based on that,\u201d Dr. Michael Eisenberg, senior author and professor of urology at Stanford, said. \u201cBut, for somebody considering fatherhood, this study emphasizes the importance of a father\u2019s health on the health of a child.\u201d<\/p>\n<p>Ultimately, he said it will be important to uncover the biological mechanisms at work and to expand the study.<\/p>\n<p><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.statista.com\/statistics\/780332\/metformin-hydrochloride-prescriptions-number-in-the-us\/\">Data<\/a>\u00a0from Statista shows that 86 million prescriptions for metformin were written in the U.S. by 2019.\n                        <\/div>\n<p><script async src=\"\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">News<\/a> articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/news\/\" target=\"_blank\" rel=\"noopener\">News category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/nypost.com\/2022\/03\/30\/boys-whose-dads-took-metformin-likely-to-have-defects-study\/\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Boys whose dads took metformin likely to have defects: study&#8221; A popular\u00a0diabetes\u00a0drug\u00a0could be linked to major birth\u00a0defects, according to researchers.\u00a0 In a study from Stanford University, the University of Southern Denmark and Copenhagen University, published Tuesday in the Annals of Internal Medicine, the authors wrote that the offspring of male patients who were taking metformin&#8230;<\/p>\n","protected":false},"author":1,"featured_media":424332,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/03\/newborn.jpg?quality=75&strip=all&w=1024","fifu_image_alt":"","footnotes":""},"categories":[70897],"tags":[127317,70292,70476,75214,70560],"class_list":["post-424331","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-3-30-22","tag-babies","tag-birth","tag-diabetes","tag-parenting"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/424331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=424331"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/424331\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/424332"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=424331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=424331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=424331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}