{"id":424910,"date":"2022-04-01T12:00:05","date_gmt":"2022-04-01T09:00:05","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/higher-blood-fats-more-harmful-than-first-thought\/"},"modified":"2022-04-01T12:00:05","modified_gmt":"2022-04-01T09:00:05","slug":"higher-blood-fats-more-harmful-than-first-thought","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/higher-blood-fats-more-harmful-than-first-thought\/","title":{"rendered":"#Higher blood fats more harmful than first thought\u00a0"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a32d3f8be9e8\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a32d3f8be9e8\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/higher-blood-fats-more-harmful-than-first-thought\/#%E2%80%9CHigher_blood_fats_more_harmful_than_first_thought_%E2%80%9C\" >&#8220;Higher blood fats more harmful than first thought\u00a0&#8220;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CHigher_blood_fats_more_harmful_than_first_thought_%E2%80%9C\"><\/span>&#8220;Higher blood fats more harmful than first thought\u00a0&#8220;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/higher-blood-fats-more.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/higher-blood-fats-more.jpg\" data-sub-html=\"Microscopy image showing human muscle cells with nuclei in blue, and stress caused by the ceramide stress signals shown in red. Credit: Lee Roberts\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/higher-blood-fats-more.jpg\" alt=\"Higher blood fats more harmful than first thought\u00a0\" title=\"Microscopy image showing human muscle cells with nuclei in blue, and stress caused by the ceramide stress signals shown in red. Credit: Lee Roberts\" width=\"507\" height=\"391\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Microscopy image showing human muscle cells with nuclei in blue, and stress caused by the ceramide stress signals shown in red. Credit: Lee Roberts<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Increased levels of blood fats in people with type 2 diabetes and obesity are more harmful than previously thought, a new study has found.\n                                                <\/p>\n<p>                                                                                In patients with metabolic diseases, elevated fat levels in the blood create stress in muscle cells\u2014a reaction to changes outside the cell which damage their structure and function.<\/p>\n<p>University of Leeds researchers have discovered that these stressed-out cells give off a signal which can be passed on to other cells. <\/p>\n<p>The signals, known as ceramides, may have a protective benefit in the short-term, because they are part of a mechanism designed to reduce stress in the cell. But in metabolic diseases, which are long term conditions, the signals can kill the cells, make symptoms more severe, and worsen the illness. <\/p>\n<p>Increased fat in the blood has long been known to damage tissues and organs, contributing to the development of cardiovascular and metabolic diseases including type 2 diabetes. The condition can be caused by obesity, rates of which have nearly <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/trip-and-travel\/\" data-internallinksmanager029f6b8e52c=\"10\" title=\"Trip &amp; Travel\" target=\"_blank\" rel=\"noopener\">trip<\/a>led worldwide since 1975. In 2016, there were more than 650 million adults aged 18 and above with obesity. <\/p>\n<p>Research supervisor Lee Roberts, Professor of Molecular Physiology and Metabolism in the University of Leeds&#8217;s School of Medicine, said: &#8220;Although this research is at an early stage, our discovery may form the basis of new therapies or therapeutic <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roaches to prevent the development of cardiovascular and metabolic diseases such as diabetes in people with elevated blood fats in obesity.&#8221; <\/p>\n<p>In the lab, the team replicated the blood fat levels observed in humans with metabolic disease by exposing skeletal muscle cells to a fatty acid called palmitate. The cells began to transmit the ceramide signal.  <\/p>\n<p>When these cells were mixed with others which had not been previously exposed to fats, the researchers found that they communicated with each other, transporting the signal in packages called extracellular vesicles.  <\/p>\n<p>The experiment was reproduced in human volunteers with metabolic diseases and gave comparable results. The findings provide a completely new angle on how cells respond to stress, with important consequences for our understanding of certain metabolic diseases including obesity. <\/p>\n<p>Professor Roberts said: &#8220;This research gives us a novel perspective on how stress develops in the cells of individuals with obesity, and provides new pathways to consider when looking to develop new treatments for metabolic diseases.  <\/p>\n<p>&#8220;With obesity an ever-increasing epidemic, the burden of associated chronic disease such as type 2 diabetes necessitates new treatments. We hope the results of our research here open a new avenue for research to help address this growing concern.&#8221; <\/p>\n<p>The paper, titled &#8220;Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle,&#8221; is published today in <i>Nature Communications<\/i>. <\/p>\n<p>The international research team included colleagues from the University of Cambridge, the University of Bonn, University of Bari, Imperial College and AstraZeneca.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Ceramides\u2014Blood lipids provide new insights into the link between diet and diabetes and cardiovascular disease\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle, <i>Nature Communications<\/i> (2022). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41467-022-29363-9\">DOI: 10.1038\/s41467-022-29363-9<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of Leeds<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.leeds.ac.uk\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Higher blood fats more harmful than first thought\u00a0 (2022, April  1)<br \/>\n                                                 retrieved  1 April 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-04-higher-blood-fats-thought.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: Lee Roberts Increased levels of blood fats in people with type 2 diabetes and obesity are more harmful than previously thought, a new study has&#8230;<\/p>\n","protected":false},"author":1,"featured_media":424911,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/higher-blood-fats-more.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-424910","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/424910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=424910"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/424910\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/424911"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=424910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=424910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=424910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}