{"id":427863,"date":"2022-04-07T09:54:44","date_gmt":"2022-04-07T06:54:44","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/sugar-substitutes-may-interfere-with-livers-ability-to-detoxify-researchers-say\/"},"modified":"2022-04-07T09:54:44","modified_gmt":"2022-04-07T06:54:44","slug":"sugar-substitutes-may-interfere-with-livers-ability-to-detoxify-researchers-say","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/sugar-substitutes-may-interfere-with-livers-ability-to-detoxify-researchers-say\/","title":{"rendered":"#Sugar substitutes may interfere with liver\u2019s ability to detoxify, researchers say"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3e213c0ee01\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3e213c0ee01\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/sugar-substitutes-may-interfere-with-livers-ability-to-detoxify-researchers-say\/#%E2%80%9CSugar_substitutes_may_interfere_with_livers_ability_to_detoxify_researchers_say%E2%80%9D\" >&#8220;Sugar substitutes may interfere with liver\u2019s ability to detoxify, researchers say&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CSugar_substitutes_may_interfere_with_livers_ability_to_detoxify_researchers_say%E2%80%9D\"><\/span>&#8220;Sugar substitutes may interfere with liver\u2019s ability to detoxify, researchers say&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<aside class=\"single__inline-module alignleft\">\n<\/aside>\n<p>Two sugar substitutes, also known as non-nutritive sweeteners, may disrupt the function of a protein that plays an important role in detoxifying the liver and the metabolizing certain\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.foxnews.com\/category\/us\/crime\/drugs\">drugs<\/a>, including blood pressure medications and antidepressants, a\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.eurekalert.org\/news-releases\/947477\">new study<\/a>\u00a0suggested.\u00a0<\/p>\n<p>These sweeteners are commonly used in\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.foxnews.com\/category\/food-drink\/food\/healthy-foods\">foods<\/a>\u00a0and even some medications to give a sweet taste while providing an alternative to table sugar with few or no calories, according to\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.foxnews.com\/category\/health\/nutrition-and-fitness\/nutrition\">nutrition<\/a>\u00a0experts.\u00a0<\/p>\n<p>\u201cWith an estimated 40% of Americans regularly consuming non-nutritive sweeteners, it\u2019s important to understand how they affect the body,\u201d Laura Danner, a doctoral student at the Medical College of Wisconsin said in the release.<\/p>\n<p>Danner, who presented the new research at the American Society for Biochemistry and Molecular Biology annual\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.asbmb.org\/meetingsevents\/2022-annual-meeting\">meeting<\/a>\u00a0this week in\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.foxnews.com\/category\/us\/philadelphia\">Philadelphia<\/a>, also said in the release, \u201cIn fact, many people don\u2019t realize that these sweeteners are found in light or zero-sugar versions of yogurts and snack foods and even in non-food products like liquid medicines and certain\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.foxnews.com\/category\/health\/beauty-and-skin\/cosmetics\">cosmetics<\/a>.\u201d\u00a0<\/p>\n<p>Non-nutritive sweeteners, acesulfame potassium and sucralose, were analyzed while using liver cells and cell-free assays, which allow the study of cellular processes such as transport, the authors explained in the release.\u00a0<\/p>\n<p>The investigators found that acesulfame potassium and sucralose inhibited the activity of a protein in the body called P-glycoprotein (PGP). PGP pumps many foreign substances out of cells, according to\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.foxnews.com\/health\">health<\/a>\u00a0experts, and is part of a group of transporters that help cleanse the body of drugs, toxins, and drug metabolites.\u00a0<\/p>\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"683\" src=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1304768995.jpg?w=1024\" alt=\"According to research, the study also showed that the sweeteners stimulate transport activity and likely bind to PGP.\" class=\"wp-image-21812367\" srcset=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1304768995.jpg?quality=75&amp;strip=all&amp;w=2048 2048w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1304768995.jpg?quality=75&amp;strip=all&amp;w=1536 1536w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1304768995.jpg?quality=75&amp;strip=all 1024w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1304768995.jpg?quality=75&amp;strip=all&amp;w=512 512w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\"\/><figcaption>According to research, the study also showed that the sweeteners stimulate transport activity and likely bind to PGP.<\/figcaption><figcaption><span class=\"credit\">Gado via Getty Images<\/span><\/figcaption><\/figure>\n<p>\u201cWe observed that sweeteners impacted PGP activity in liver cells at concentrations expected through consumption of common foods and beverages, far below the recommended FDA maximum limits,\u201d Stephanie Olivier Van Stichelen, PhD, who lead the research team, said in the release. \u201cTo our knowledge, we are the first group to decipher the molecular mechanism by which non-nutritive sweeteners impact detoxification in the liver.\u201d\u00a0<\/p>\n<p>According to the team\u2019s work, the study also showed that the sweeteners stimulate transport activity and likely bind to PGP. This causes a competition with and inhibits the transport of other substrates such as xenobiotics, drugs and their metabolites, short-chain lipids and bile acids, the release stated. According to a presentation by Danner, this potentially leaves other PGP substrates such as certain medications left tr<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>ed in cells, possibly leading to\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.eurekalert.org\/multimedia\/822884\">liver toxicity<\/a>.<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-nypost-small-post\"><img decoding=\"async\" loading=\"lazy\" width=\"231\" height=\"345\" src=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1371632327.jpg?w=231\" alt=\"The non-nutritive sweeteners may disrupt the function of a protein that plays an important role in detoxifying the liver.\" class=\"wp-image-21812464\" srcset=\"https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1371632327.jpg?quality=75&amp;strip=all&amp;w=462 462w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1371632327.jpg?quality=75&amp;strip=all&amp;w=347 346w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1371632327.jpg?quality=75&amp;strip=all&amp;w=231 231w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1371632327.jpg?quality=75&amp;strip=all&amp;w=116 115w, https:\/\/nypost.com\/wp-content\/uploads\/sites\/2\/2022\/04\/GettyImages-1371632327.jpg?quality=75&amp;strip=all 1024w\" sizes=\"auto, (max-width: 231px) 100vw, 231px\"\/><figcaption>The non-nutritive sweeteners may disrupt the function of a protein that plays an important role in detoxifying the liver.<\/figcaption><figcaption><span class=\"credit\"><a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">Media<\/a><a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">News<\/a> Group via Getty Images<\/span><\/figcaption><\/figure>\n<\/div>\n<p>In a case where an individual takes blood pressure medications, antidepressants and antibiotics, which are medications that rely on PGP as a primary detoxification transporter, this could be problematic, the researchers said in the release.\u00a0<\/p>\n<p>The researchers did recommend that the findings be further confirmed through preclinical and clinical studies, since their study is preliminary.\u00a0<\/p>\n<p>\u201cIf future\u00a0<a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.foxnews.com\/category\/food-drink\/food\/studies\">studies<\/a>\u00a0confirm that non-nutritive sweeteners impair the body\u2019s detoxification process, it would be essential to study the potential interactions and determine safe levels of consumption for at-risk groups,\u201d Danner said in the release and added, \u201cIt might also be important to include specific amounts non-nutritive sweeteners included on food labels so that people can better track their intake.\u201d\u00a0]<\/p>\n<p>The researchers noted in the release that PGP also plays a role with maintaining the blood-brain barrier and therefore it is important to explore how inhibition of this protein may interfere with the function of cells in other organs besides the liver.\u00a0<\/p>\n<p>The researchers plan on conducting further research on the two sweeteners using more complex models of drug transport and also plan on studying mixes of these sweeteners, since that is typically how they are found in food products.\n                        <\/p><\/div>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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