{"id":428912,"date":"2022-04-08T23:30:38","date_gmt":"2022-04-08T20:30:38","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/study-shows-important-change-in-b-cells-in-women-with-ppd\/"},"modified":"2022-04-08T23:30:38","modified_gmt":"2022-04-08T20:30:38","slug":"study-shows-important-change-in-b-cells-in-women-with-ppd","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/study-shows-important-change-in-b-cells-in-women-with-ppd\/","title":{"rendered":"#Study shows important change in B-cells in women with PPD"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a33741cc7bcd\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a33741cc7bcd\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/study-shows-important-change-in-b-cells-in-women-with-ppd\/#%E2%80%9CStudy_shows_important_change_in_B-cells_in_women_with_PPD%E2%80%9D\" >&#8220;Study shows important change in B-cells in women with PPD&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CStudy_shows_important_change_in_B-cells_in_women_with_PPD%E2%80%9D\"><\/span>&#8220;Study shows important change in B-cells in women with PPD&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2019\/bcellblympho.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2019\/bcellblympho.jpg\" data-sub-html=\"3D rendering of a B cell. Credit: Blausen.com staff (2014). &quot;Medical gallery of Blausen Medical 2014&quot;. WikiJournal of Medicine 1 (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436. CC BY-SA 4.0\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2019\/bcellblympho.jpg\" alt=\"B cell , B lymphocyte\" title=\"3D rendering of a B cell. Credit: Blausen.com staff (2014). &quot;Medical gallery of Blausen Medical 2014&quot;. WikiJournal of Medicine 1 (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436. CC BY-SA 4.0\" width=\"800\" height=\"480\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                3D rendering of a B cell. Credit: Blausen.com staff (2014). &#8220;Medical gallery of Blausen Medical 2014&#8221;. WikiJournal of Medicine 1 (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436. CC BY-SA 4.0<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A study published in <i>Molecular Psychiatry <\/i>is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it. PPD affects 1 in 7 women and has negative mental health consequences for both mother and child. However, the precise biological mechanisms behind the disorder are unknown.\n                                                <\/p>\n<p>                                                                                &#8220;We don&#8217;t have PPD figured out,&#8221; said lead author Jerry Guintivano, Ph.D., assistant professor in the UNC Department of Psychiatry. &#8220;A lot of biological research focuses on candidate genes and hormones, and we do have a lead on some PPD-specific medications, but it&#8217;s important to take multiple avenues to target this condition. Not every manifestation of PPD is the same.&#8221;<\/p>\n<p>That&#8217;s why Guintivano led a team of researchers from the UNC School of Medicine to conduct the largest tran<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">script<\/a>ome-wide association study for PPD to date. Previous studies have only analyzed whole blood samples. This study took a deeper look and examined the different components of blood. They took blood samples from 1,500 racially and ethnically diverse women from across North Carolina who had given birth within the past six weeks, 482 of whom were diagnosed with PPD. Researchers used RNA sequencing, DNA genotyping, and assessment of DNA methylation\u2014amounting to three levels of basic biology evaluation\u2014to look for differences in components of the blood samples from women with PPD versus women without PPD.<\/p>\n<p>They found that B-cells had significant differences in women with PPD. B-cells are an important part of the immune system. They become activated when their receptor recognizes an antigen and binds to it. Activated B-cells then produce antibodies, and also secrete pro- and anti-inflammatory factors.<\/p>\n<p>&#8220;There&#8217;s a really delicate interplay of the immune system during pregnancy,&#8221; Guintivano said. &#8220;It has to prevent infection from a cold, and it also has to finely tune itself so it doesn&#8217;t recognize the fetus as a foreign body and attack it. Then in the postpartum period, all these hormones and pathways reset to get back to pre-pregnancy.&#8221;<\/p>\n<p>In women with PPD, the UNC researchers found thousands of individual B-cell transcripts that were different from women without PPD, regulated in part by genetic variants and DNA methylation. To confirm those findings they conducted pathway analysis, which implicated altered B-cell activation and insulin resistance.<\/p>\n<p>&#8220;This is really just the first step in a long line of research that now needs to be done,&#8221; Guintivano said. &#8220;This is the biggest study of its type but we still don&#8217;t know why B-cells are changing. Are they reflecting another change in the body that is caused by or causes PPD? What is driving this B-cell behavior?&#8221;<\/p>\n<p>Guintivano says their next step is to conduct a longitudinal study that tracks women across a longer period of time to see how B-cells change through pregnancy and into the postpartum period. He says none of this research would be possible without many women being dedicated to research on PPD.<\/p>\n<p>&#8220;The women who participated in this study are new moms who came in during a very critical time when their babies are weeks old to participate in research to help other women, Guintivano said. &#8220;I want to thank them for that. We want to do their contributions justice with our research.&#8221;\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Postpartum trajectory differs by race after hypertensive disorders of pregnancy\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Jerry Guintivano et al, Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance, <i>Molecular Psychiatry<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41380-022-01525-7\">DOI: 10.1038\/s41380-022-01525-7<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of North Carolina Health Care<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.med.unc.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Study shows important change in B-cells in women with PPD (2022, April  8)<br \/>\n                                                 retrieved  9 April 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-04-important-b-cells-women-ppd.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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Credit: Blausen.com staff (2014). &#8220;Medical gallery of Blausen Medical 2014&#8221;. WikiJournal of Medicine 1 (2). DOI:10.15347\/wjm\/2014.010. ISSN 2002-4436. CC BY-SA 4.0 A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women&#8230;<\/p>\n","protected":false},"author":1,"featured_media":428913,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2019\/bcellblympho.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-428912","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/428912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=428912"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/428912\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/428913"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=428912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=428912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=428912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}