{"id":432474,"date":"2022-04-15T20:34:58","date_gmt":"2022-04-15T17:34:58","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/targeting-cell-clustering-by-gene-deletion-reduces-drug-resistance\/"},"modified":"2022-04-15T20:34:58","modified_gmt":"2022-04-15T17:34:58","slug":"targeting-cell-clustering-by-gene-deletion-reduces-drug-resistance","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/targeting-cell-clustering-by-gene-deletion-reduces-drug-resistance\/","title":{"rendered":"#Targeting &#8216;cell clustering&#8217; by gene deletion reduces drug resistance"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a271449b7b5b\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a271449b7b5b\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/targeting-cell-clustering-by-gene-deletion-reduces-drug-resistance\/#%E2%80%9CTargeting_%E2%80%98cell_clustering_by_gene_deletion_reduces_drug_resistance%E2%80%9D\" >&#8220;Targeting &#8216;cell clustering&#8217; by gene deletion reduces drug resistance&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CTargeting_%E2%80%98cell_clustering_by_gene_deletion_reduces_drug_resistance%E2%80%9D\"><\/span>&#8220;Targeting &#8216;cell clustering&#8217; by gene deletion reduces drug resistance&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/targeting-cell-cluster.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/targeting-cell-cluster.jpg\" data-sub-html=\"Image of clustering yeast cells and yeast cells separated after removal of the AMN1 gene. Credit: G\u00e1bor Bal\u00e1zsi\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/targeting-cell-cluster.jpg\" alt=\"Targeting \u201cCell Clustering\u201d by Gene Deletion Reduces Drug Resistance\" title=\"Image of clustering yeast cells and yeast cells separated after removal of the AMN1 gene. Credit: G\u00e1bor Bal\u00e1zsi\" width=\"600\" height=\"333\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Image of clustering yeast cells and yeast cells separated after removal of the AMN1 gene. Credit: G\u00e1bor Bal\u00e1zsi<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A recent study that shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roach to combatting drug resistance when treating microbial infections or cancer. Led by G\u00e1bor Bal\u00e1zsi, Ph.D., of Stony Brook University, and published in <i>Communications Biology<\/i>, the study centers on disassembling cell clusters that can form an added barrier of drug resistance in the disease process.\n                                                <\/p>\n<p>                                                                                Drug resistance is a major global health challenge. Knowing how microbial and cancer cells resist drugs can help with the development of better drugs to treat disease. While scientists have uncovered a great deal about individual molecular mechanisms of resistance, the problem of multicellular mechanisms that resist drug treatments is more difficult. One of these multicellular mechanisms of resistance is a phenomenon where cells say together forming clusters, which reduce drug uptake.<\/p>\n<p>Bal\u00e1zsi and colleagues used a budding yeast (Saccharomyces cerevisiae) as an experimental model that exhibited antifungal drug resistance and cell clustering. They removed the AMN1 gene, which was responsible for cell clustering in this model.<\/p>\n<p>&#8220;We found that after we deleted this gene, cells stayed alone and no multicellular clumps formed,&#8221; explains Bal\u00e1zsi, lead author and the Henry Laufer Professor for the Louis and Beatrice Center for Physical &amp; Quantitative Biology, and Professor in the Department of Biomedical Engineering at the Renaissance School of Medicine at Stony Brook University. &#8220;Furthermore, the resulting unicellular yeast was more sensitive to four common antifungal chemicals. This suggests that disrupting multicellular clumps may lead to more effective treatments.&#8221;<\/p>\n<p>The research team includes co-authors Lesia Guinn and Evan Lo, who performed experiments and developed mathematical models with Bal\u00e1zsi to quantitate the drug effects and to tease apart the various effects of the AMN1 deletion.<\/p>\n<p>Overall, the findings suggest that AMN1 may be a future gene target for antifungal therapies against cluster-forming infectious fungi.<\/p>\n<p>The authors suggest similar cluster-disruptive strategies could be developed and tested to better eliminate cluster-forming infectious microbes or circulating tumor cell clusters.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/phys.org\/news\/2019-11-evolution-genes-regain-function.html\">Study shows evolution turns genes back on to regain function<\/a>\n                                                                                    <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Lesia Guinn et al, Drug-dependent growth curve reshaping reveals mechanisms of antifungal resistance in Saccharomyces cerevisiae, <i>Communications Biology<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s42003-022-03228-9\">DOI: 10.1038\/s42003-022-03228-9<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Stony Brook University<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.stonybrook.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Targeting &#8216;cell clustering&#8217; by gene deletion reduces drug resistance (2022, April 15)<br \/>\n                                                 retrieved 16 April 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-04-cell-clustering-gene-deletion-drug.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: G\u00e1bor Bal\u00e1zsi A recent study that shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating&#8230;<\/p>\n","protected":false},"author":1,"featured_media":432475,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/targeting-cell-cluster.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-432474","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/432474","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=432474"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/432474\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/432475"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=432474"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=432474"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=432474"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}