{"id":432696,"date":"2022-04-16T16:20:01","date_gmt":"2022-04-16T13:20:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/nasal-antiviral-blocks-sars-cov-2-infection-in-mice\/"},"modified":"2022-04-16T16:20:01","modified_gmt":"2022-04-16T13:20:01","slug":"nasal-antiviral-blocks-sars-cov-2-infection-in-mice","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/nasal-antiviral-blocks-sars-cov-2-infection-in-mice\/","title":{"rendered":"#Nasal antiviral blocks SARS-CoV-2 infection in mice"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3aa2fc0d4c1\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3aa2fc0d4c1\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/nasal-antiviral-blocks-sars-cov-2-infection-in-mice\/#%E2%80%9CNasal_antiviral_blocks_SARS-CoV-2_infection_in_mice%E2%80%9D\" >&#8220;Nasal antiviral blocks SARS-CoV-2 infection in mice&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CNasal_antiviral_blocks_SARS-CoV-2_infection_in_mice%E2%80%9D\"><\/span>&#8220;Nasal antiviral blocks SARS-CoV-2 infection in mice&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/nasal-antiviral-blocks.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/nasal-antiviral-blocks.jpg\" data-sub-html=\"Colorized scanning electron micrograph of cells (tan) infected with a variant strain of SARS-CoV-2 virus particles (purple), isolated from a patient sample. Credit: NIAID Integrated Research Facility\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/nasal-antiviral-blocks.jpg\" alt=\"Nasal antiviral blocks SARS-CoV-2 infection in mice\" title=\"Colorized scanning electron micrograph of cells (tan) infected with a variant strain of SARS-CoV-2 virus particles (purple), isolated from a patient sample. Credit: NIAID Integrated Research Facility\" width=\"382\" height=\"328\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Colorized scanning electron micrograph of cells (tan) infected with a variant strain of SARS-CoV-2 virus particles (purple), isolated from a patient sample. Credit: NIAID Integrated Research Facility<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>SARS-CoV-2, the virus that causes COVID-19, has continuously mutated since it emerged in late 2019. This rapid evolution poses challenges for vaccines and treatments designed to target the virus. A booster shot is now needed to produce antibodies to fight off the Omicron variant of SARS-CoV-2. And several combinations of antibody treatments <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roved earlier in the pandemic don&#8217;t work well against Omicron.\n                                                <\/p>\n<p>                                                                                An alternate approach to treating COVID-19 is blocking proteins on human cells that the virus uses to infect them. These proteins change very little, if at all, over time.<\/p>\n<p>A team led by Dr. Hector Aguilar-Carre\u00f1o from Cornell University and collaborators in Canada have been developing compounds that can block one such protein, called TMPRSS2. The virus needs this protein to help its spike protein fuse with the cell membrane and get inside the cell.<\/p>\n<p>The work was funded in part by NIH&#8217;s National Institute of Allergy and Infectious Diseases (NIAID). Results were published on March 28, 2022, in <i>Nature<\/i>.<\/p>\n<p>In experiments in cells, several of the new compounds inhibited the activity of TMPRSS2, some by more than 80%. Four of the most promising compounds worked well at very low concentrations and had no negative impact on normal cell survival.<\/p>\n<p>The researchers next screened these top candidates for their ability to prevent SARS-CoV-2 from infecting cells. The most effective compound, called N-0385, substantially reduced the amount of virus that could get into cells derived from lung and colon tissues. Similar results were seen with newer variants of the virus, including Delta.<\/p>\n<p>The team then tested delivering N-0385 through the nose in a mouse model of severe COVID-19. Antiviral nasal sprays should have several potential advantages for treatment. SARS-CoV-2 enters the body mainly through the nose. Nasal sprays could easily be used by people at home. And delivering drugs directly into the nose and lungs reduces exposure to the rest of the body, potentially limiting side effects.<\/p>\n<p>The researchers first gave N-0385 once a day, starting one day before viral exposure through 6 days afterwards. None of the ten mice that received a control dose of saline survived, but seven of the ten that received N-0385 did. Most of the mice that survived had little or no lung damage.<\/p>\n<p>When the team repeated the experiment with a shorter course of treatment, from one day before exposure through 2 days afterwards, all 10 of the mice given N-0385 survived. In contrast, only one of the 10 that received the saline lived. Samples taken from 3 days after infection found that mice treated with N-0385 had 97% less virus in the lungs. When the experiment was done with only a single dose of N-0385 given the day of infection, treated mice had a high survival rate as well.<\/p>\n<p>The treatment also showed protection against the Delta variant. These experiments were done before Omicron. However, because N-0385 works on host cells, it&#8217;s likely to be able to block different variants from using the target host proteins.<\/p>\n<p>&#8220;The N-0385 therapy is simpler and less expensive to mass produce than other types of COVID-19 treatments, such as monoclonal antibodies,&#8221; Aguilar-Carre\u00f1o notes.<\/p>\n<p>The researchers are currently working with a bio<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> company to produce a version of the drug for testing in people.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Promising nose spray could prevent, treat COVID-19\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Tirosh Shapira et al, A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic, <i>Nature<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41586-022-04661-w\">DOI: 10.1038\/s41586-022-04661-w<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    National Institutes of Health<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.nih.gov\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Nasal antiviral blocks SARS-CoV-2 infection in mice (2022, April 16)<br \/>\n                                                 retrieved 16 April 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-04-nasal-antiviral-blocks-sars-cov-infection.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2022-04-nasal-antiviral-blocks-sars-cov-infection.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Nasal antiviral blocks SARS-CoV-2 infection in mice&#8221; Colorized scanning electron micrograph of cells (tan) infected with a variant strain of SARS-CoV-2 virus particles (purple), isolated from a patient sample. Credit: NIAID Integrated Research Facility SARS-CoV-2, the virus that causes COVID-19, has continuously mutated since it emerged in late 2019. This rapid evolution poses challenges for&#8230;<\/p>\n","protected":false},"author":1,"featured_media":432697,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/nasal-antiviral-blocks.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-432696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/432696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=432696"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/432696\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/432697"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=432696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=432696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=432696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}