{"id":436398,"date":"2022-04-23T20:40:01","date_gmt":"2022-04-23T17:40:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/study-mines-cancer-genetics-to-help-with-targeted-treatment\/"},"modified":"2022-04-23T20:40:01","modified_gmt":"2022-04-23T17:40:01","slug":"study-mines-cancer-genetics-to-help-with-targeted-treatment","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/study-mines-cancer-genetics-to-help-with-targeted-treatment\/","title":{"rendered":"#Study mines cancer genetics to help with targeted treatment"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a36e9f4119ce\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a36e9f4119ce\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/study-mines-cancer-genetics-to-help-with-targeted-treatment\/#%E2%80%9CStudy_mines_cancer_genetics_to_help_with_targeted_treatment%E2%80%9D\" >&#8220;Study mines cancer genetics to help with targeted treatment&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CStudy_mines_cancer_genetics_to_help_with_targeted_treatment%E2%80%9D\"><\/span>&#8220;Study mines cancer genetics to help with targeted treatment&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/study-mines-cancer-gen.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/study-mines-cancer-gen.jpg\" data-sub-html=\"This microscope image made available by the National Cancer Institute Center for Cancer Research in 2015 shows human colon cancer cells with the nuclei stained red. Cancer is a disease of the genome, or full set of instructions for running cells, that occurs when changes in a person\u2019s DNA cause cells to grow and divide uncontrollably. Credit: NCI Center for Cancer Research via AP\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/study-mines-cancer-gen.jpg\" alt=\"Study mines cancer genetics to help with targeted treatment\" title=\"This microscope image made available by the National Cancer Institute Center for Cancer Research in 2015 shows human colon cancer cells with the nuclei stained red. Cancer is a disease of the genome, or full set of instructions for running cells, that occurs when changes in a person\u2019s DNA cause cells to grow and divide uncontrollably. Credit: NCI Center for Cancer Research via AP\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                This microscope image made available by the National Cancer Institute Center for Cancer Research in 2015 shows human colon cancer cells with the nuclei stained red. Cancer is a disease of the genome, or full set of instructions for running cells, that occurs when changes in a person\u2019s DNA cause cells to grow and divide uncontrollably. Credit: NCI Center for Cancer Research via AP<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Scientists have analyzed the full genetic blueprints of more than 18,000 cancer samples, finding new patterns of mutations that could help doctors provide better, more personalized treatment.\n                                                <\/p>\n<p>                                                                                Their study, published Thursday in the journal <i><a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a><\/i>, isn&#8217;t the first to do such comprehensive &#8220;whole genome&#8221; analyses of cancer samples. But no one has ever done so many.<\/p>\n<p>&#8220;This is the largest cohort in the world. It is extraordinary,&#8221; said Serena Nik-Zainal of the University of Cambridge, who was part of the team.<\/p>\n<p>Just over 12,200 surgical specimens came from patients recruited from the U.K. National Health Service as part of a project to study whole genomes from people with common cancers and rare diseases. The rest came from existing cancer data sets.<\/p>\n<p>Researchers were able to analyze such a large number because of the same improvements in genetic sequencing <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/technology\/\" data-internallinksmanager029f6b8e52c=\"4\" title=\"Technology\" target=\"_blank\" rel=\"noopener\">technology<\/a> that recently allowed scientists to finally finish decoding the entire human genome\u2014more capable, accurate machines.<\/p>\n<p>&#8220;We can really begin to tease out the underpinnings of the erosive sort of forces that go to sort of generate cancer,&#8221; said Andrew Futreal, a genomic medicine expert at MD Anderson Cancer Center in Houston who was not involved in the study.<\/p>\n<p>Cancer is a disease of the genome, or full set of instructions for running cells, that occurs when changes in a person&#8217;s DNA cause cells to grow and divide uncontrollably. In 2020, there were about 19 million new cancer cases worldwide.<\/p>\n<p>For the study, researchers looked at 19 different types\u2014breast, colorectal, prostate, brain and others\u2014and identified 58 new clues to the causes of cancer called &#8220;mutational signatures&#8221; that contribute to the development of the disease. They also confirmed 51 of more than 70 previously reported mutation patterns, Nik-Zainal said.<\/p>\n<p>Some arise because of problems within a person&#8217;s cells; others are sparked by environmental exposures such as ultraviolet radiation, tobacco smoke or chemicals.<\/p>\n<p>Knowing more of them &#8220;helps us to understand each person&#8217;s cancer more precisely,&#8221; which can help guide treatment, Nik-Zainal said.<\/p>\n<p>Genetic sequencing is already being woven into cancer care as part of the growing trend of personalized medicine, or care based on a patient&#8217;s genes and specific disease. Now doctors will have much more information to draw from when they look at individual cancers.<\/p>\n<p>To help doctors use this information, researchers developed a computer algorithm that will allow them to find common mutation patterns and seek out rare ones. Based on a particular pattern, Nik-Zainal said a doctor may suggest a certain course of action, such as getting immunotherapy.<\/p>\n<p>Futreal said the data can also show doctors what tends to h<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>en over time when a patient develops a cancer with a certain mutation pattern\u2014helping them intervene earlier and hopefully stop the developing disease in its tracks.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Largest study of whole genome sequencing data reveals &#8216;treasure trove&#8217; of clues about causes of cancer\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Andrea Degasperi et al, Substitution mutational signatures in whole-genome-sequenced cancers of the UK national health service, <i>Science<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1126\/science.abl9283\">DOI: 10.1126\/science.abl9283<\/a>. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abl9283\">www.science.org\/doi\/10.1126\/science.abl9283<\/a><\/p><\/div>\n<p class=\"article-main__note mt-4\">\n                                                \u00a9 2022 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Study mines cancer genetics to help with targeted treatment (2022, April 23)<br \/>\n                                                 retrieved 23 April 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-04-cancer-genetics-treatment.html<\/p>\n<p>                                            This document is subject to copyright. 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Cancer is a disease of the genome, or full set of instructions for running cells, that occurs when changes in&#8230;<\/p>\n","protected":false},"author":1,"featured_media":436399,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/study-mines-cancer-gen.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-436398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/436398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=436398"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/436398\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/436399"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=436398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=436398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=436398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}