{"id":460014,"date":"2022-06-09T14:20:07","date_gmt":"2022-06-09T11:20:07","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/gene-variant-gives-mice-super-powered-tendons-for-jumping-and-running\/"},"modified":"2022-06-09T14:20:07","modified_gmt":"2022-06-09T11:20:07","slug":"gene-variant-gives-mice-super-powered-tendons-for-jumping-and-running","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/gene-variant-gives-mice-super-powered-tendons-for-jumping-and-running\/","title":{"rendered":"#Gene variant gives mice super-powered tendons for jumping and running"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3945ffb21ee\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3945ffb21ee\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/gene-variant-gives-mice-super-powered-tendons-for-jumping-and-running\/#%E2%80%9CGene_variant_gives_mice_super-powered_tendons_for_jumping_and_running%E2%80%9D\" >&#8220;Gene variant gives mice super-powered tendons for jumping and running&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CGene_variant_gives_mice_super-powered_tendons_for_jumping_and_running%E2%80%9D\"><\/span>&#8220;Gene variant gives mice super-powered tendons for jumping and running&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/gene-variant-gives-mic.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/gene-variant-gives-mic.jpg\" data-sub-html=\"Tendon-specific R2482H Piezo1 enhances jumping power and maximum running speed in mice. (A) Representative images of jumping in WT, Piezo1&lt;sup&gt;systemic-mut\/+&lt;\/sup&gt;, Piezo1&lt;sup&gt;tendon-mut\/+&lt;\/sup&gt;, and Piezo1&lt;sup&gt;muscle-mut\/+&lt;\/sup&gt;mice. (B) Maximum jumping distance of each mouse. Male and female. n = 10 of each. Error bars represent SDs; *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, and ****P &lt; 0.0001, Tukey\u2019s multiple comparisons test. (C and D) Running distance (C) and maximum running speed (D) during the run-to-exhaustion test in WT, Piezo1&lt;sup&gt;systemic-mut\/+&lt;\/sup&gt;, Piezo1&lt;sup&gt;tendon-mut\/+&lt;\/sup&gt;, and Piezo1&lt;sup&gt;muscle-mut\/+&lt;\/sup&gt;mice. n = 10. Error bars represent SDs; *P &lt; 0.05 and **P &lt; 0.01, Dunn\u2019s multiple comparisons test. Credit: &lt;i&gt;Science Translational Medicine&lt;\/i&gt; (2022). DOI: 10.1126\/scitranslmed.abj5557\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/gene-variant-gives-mic.jpg\" alt=\"Gene variant gives mice super-powered tendons for jumping and running\" title=\"Tendon-specific R2482H Piezo1 enhances jumping power and maximum running speed in mice. (A) Representative images of jumping in WT, Piezo1&lt;sup&gt;systemic-mut\/+&lt;\/sup&gt;, Piezo1&lt;sup&gt;tendon-mut\/+&lt;\/sup&gt;, and Piezo1&lt;sup&gt;muscle-mut\/+&lt;\/sup&gt;mice. (B) Maximum jumping distance of each mouse. Male and female. n = 10 of each. Error bars represent SDs; *P &lt; 0.05, **P &lt; 0.01, ***P &lt; 0.001, and ****P &lt; 0.0001, Tukey\u2019s multiple comparisons test. (C and D) Running distance (C) and maximum running speed (D) during the run-to-exhaustion test in WT, Piezo1&lt;sup&gt;systemic-mut\/+&lt;\/sup&gt;, Piezo1&lt;sup&gt;tendon-mut\/+&lt;\/sup&gt;, and Piezo1&lt;sup&gt;muscle-mut\/+&lt;\/sup&gt;mice. n = 10. Error bars represent SDs; *P &lt; 0.05 and **P &lt; 0.01, Dunn\u2019s multiple comparisons test. Credit: &lt;i&gt;Science Translational Medicine&lt;\/i&gt; (2022). DOI: 10.1126\/scitranslmed.abj5557\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Tendon-specific R2482H Piezo1 enhances jumping power and maximum running speed in mice. (A) Representative images of jumping in WT, Piezo1<sup>systemic-mut\/+<\/sup>, Piezo1<sup>tendon-mut\/+<\/sup>, and Piezo1<sup>muscle-mut\/+<\/sup>mice. (B) Maximum jumping distance of each mouse. Male and female. n = 10 of each. Error bars represent SDs; *P systemic-mut\/+, Piezo1<sup>tendon-mut\/+<\/sup>, and Piezo1<sup>muscle-mut\/+<\/sup>mice. n = 10. Error bars represent SDs; *P <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a> Translational Medicine (2022). DOI: 10.1126\/scitranslmed.abj5557<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>When you <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>laud the strength and speed of an animal or athlete, you probably don&#8217;t praise their tendons (the cords of connective tissue that attach muscles to bones)\u2014but maybe you should. Scientists at Scripps Research have discovered a genetic mutation that gives tendons the ability to store more energy, letting mice jump higher and reach faster speeds than usual, as the team reported June 1, 2022, in <i>Science Translational Medicine<\/i>. Preliminary data on humans suggests that the gene variant, which is in a sensor protein known as PIEZO1, might play a similar role in people.\n                                                <\/p>\n<p>                                                                                &#8220;Based on our data, PIEZO1 plays a key role in the properties of tendons,&#8221; says senior author Hiroshi Asahara, MD, Ph.D., professor of Molecular Medicine at Scripps Research. &#8220;It also has the potential to be a therapeutic target for treating age-related declines in physical performance.&#8221;<\/p>\n<p>The PIEZO1 protein is a touch-sensitive ion channel; it sits on the membranes of cells and, when it detects pressure, opens to allow charge ions to flow through. It was first discovered in 2010 by Scripps Research professor Ardem Patapoutian, Ph.D., who won the 2021 Nobel Prize in Physiology or Medicine in part for the finding and for showing how the related protein PIEZO2 enables our senses of touch and proprioception.<\/p>\n<p>&#8220;This new role of PIEZO1 in tendon biology, identified in mice, underscores just how important this group of ion channels is,&#8221; says Patapoutian, who is also a Howard Hughes Medical Investigator and who collaborated with Asahara on the new work. &#8220;We&#8217;re discovering more possible new roles of PIEZOs in health and disease as we keep studying them.&#8221;<\/p>\n<p><b>Supercharged mice<\/b><\/p>\n<p>In the years since Patapoutian discovered PIEZO1, the protein has been shown to play a role in the development of blood vessels, heart, bone and immune cells. Last year, Patapoutian&#8217;s group found that a variant of the PIEZO1 gene, carried by up to a third of people of African descent, helps protect against malaria but may predispose people to high levels of iron in their blood.<\/p>\n<p>Recently, another group of researchers found that PIEZO1 regulates MKX, a gene that Asahara discovered and was already studying for its importance in tendon development. Asahara wondered how the PIEZO1 gene variant probed by Patapoutian&#8217;s group might impact tendons.<\/p>\n<p>The researchers studied mice with a genetic change to PIEZO1 that led to the same effect as that seen in humans: the PIEZO1 ion channel closes more slowly every time it is activated. Some mice had the genetic alteration in all the cells in their body, some only in muscle cells, and some only in tendon cells. Mice with the genetic change in all their cells, or in tendons alone, could jump about one and a half times further than other mice. When the researchers tested how far the mice could run, they found no difference in endurance, but observed that the mice with the PIEZO1 mutation in either all their cells or their tendons could reach higher top speeds.<br \/>\n                                            <!-- Google middle Adsense block --><\/p>\n<p>&#8220;All these results suggested that this PIEZO1 mutation is enhancing tendon tissue in a way that really impacts physical ability,&#8221; says first author of the paper Ryo Nakamichi, MD, Ph.D., a former member of the Asahara lab who is now working as an orthopedic surgeon at Okayama University in Japan.<\/p>\n<p>When the team repeated the experiments with mice that had normal PIEZO1 activity during embryonic development but the PIEZO1 mutation after birth, they observed the same results\u2014suggesting that the impact of the mutation is not only on the initial development of tendons.<\/p>\n<p>To learn how the PIEZO1 variation might be giving mice the ability to jump higher and run faster, the researchers took a closer look at the animals&#8217; muscles and tendons. Overall, they found high levels of the PIEZO1 gene in tendon cells and low levels in muscle cells, suggesting that the gene was not important to muscle function. In tendons, the ion channel was responsible for letting calcium flow in and out of cells, they showed. This altered flow of calcium changed the levels of a number of other genes\u2014including MKX\u2014that are involved in the generation and structure of tendon cells.<\/p>\n<p>When Nakamichi, Asahara and colleagues measured the Achille&#8217;s tendons of the mice, they discovered that mice with the PIEZO1 mutation had tendons that were about 1.2 times wider, as well as wider fibrils composing each tendon. Further analysis showed that the tendons from mice with the PIEZO1 mutation were more compliant\u2014the opposite of stiff\u2014and could store about three times more energy than tendons from other mice, explaining their improved ability to jump and sprint. There were no differences in the muscles or nerves of the animals.<\/p>\n<p><b>Jumping to humans<\/b><\/p>\n<p>To probe how their findings in mice might translate to humans, the group teamed up with researchers at the Athlome Consortium, who collect genetic information on elite athletes. Among 91 Jamaican sprinters in the Athlome database, 46% had one copy of PIEZO1 with the tendon-impacting mutation and 8% had two copies of the mutation. Among Jamaican students who had not competed in track events, 31% had one version of the mutation and only 2% had two copies. Data on Greek athletes showed similar trends, with 3 to 5 times more sprinters having two copies of the mutation than controls, and 1.3 to 1.75 times more sprinters having one copy of the mutation compared to controls.<\/p>\n<p>&#8220;These data suggested that what we observed in mice might hold true in humans but more work is needed to understand the full role of PIEZO1 in human tendons,&#8221; says Asahara.<\/p>\n<p>The researchers say that in the future, targeting the protein could help treat tendon injuries or combat age-related declines in movement.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Why exercise gets harder the less you do\u00a0\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Ryo Nakamichi et al, The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance, <i>Science Translational Medicine<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1126\/scitranslmed.abj5557\">DOI: 10.1126\/scitranslmed.abj5557<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    The Scripps Research Institute<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.scripps.edu\/e_index.html\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Gene variant gives mice super-powered tendons for jumping and running (2022, June  9)<br \/>\n                                                 retrieved  9 June 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-06-gene-variant-mice-super-powered-tendons.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2022-06-gene-variant-mice-super-powered-tendons.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Gene variant gives mice super-powered tendons for jumping and running&#8221; Tendon-specific R2482H Piezo1 enhances jumping power and maximum running speed in mice. (A) Representative images of jumping in WT, Piezo1systemic-mut\/+, Piezo1tendon-mut\/+, and Piezo1muscle-mut\/+mice. (B) Maximum jumping distance of each mouse. Male and female. n = 10 of each. Error bars represent SDs; *P systemic-mut\/+, Piezo1tendon-mut\/+,&#8230;<\/p>\n","protected":false},"author":1,"featured_media":460015,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/gene-variant-gives-mic.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-460014","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/460014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=460014"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/460014\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/460015"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=460014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=460014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=460014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}