{"id":463178,"date":"2022-06-15T12:27:54","date_gmt":"2022-06-15T09:27:54","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/genetic-discovery-could-spell-mosquitoes-death-knell\/"},"modified":"2022-06-15T12:27:54","modified_gmt":"2022-06-15T09:27:54","slug":"genetic-discovery-could-spell-mosquitoes-death-knell","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/genetic-discovery-could-spell-mosquitoes-death-knell\/","title":{"rendered":"#Genetic discovery could spell mosquitoes&#8217; death knell"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a2f4ebb30af1\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a2f4ebb30af1\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/genetic-discovery-could-spell-mosquitoes-death-knell\/#%E2%80%9CGenetic_discovery_could_spell_mosquitoes_death_knell%E2%80%9D\" >&#8220;Genetic discovery could spell mosquitoes&#8217; death knell&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CGenetic_discovery_could_spell_mosquitoes_death_knell%E2%80%9D\"><\/span>&#8220;Genetic discovery could spell mosquitoes&#8217; death knell&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/genetic-discovery-coul.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/genetic-discovery-coul.jpg\" data-sub-html=\"Larval and pupal developmental stages of yellow fever-carrying mosquito. Credit: Lewis Hun\/UCR\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/genetic-discovery-coul.jpg\" alt=\"Genetic discovery could spell mosquitoes' death knell\" title=\"Larval and pupal developmental stages of yellow fever-carrying mosquito. Credit: Lewis Hun\/UCR\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Larval and pupal developmental stages of yellow fever-carrying mosquito. Credit: Lewis Hun\/UCR<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A UC Riverside genetic discovery could turn disease-carrying mosquitoes into insect Peter Pans, preventing them from ever maturing or multiplying.<\/p>\n<section class=\"article-banner first-banner ads-336x280\">\n         <!-- \/4988204\/Phys_Story_InText_Box --><\/p>\n<\/section>\n<p>In 2018, UCR entomologist Naoki Yamanaka found, contrary to accepted scientific wisdom, that an important steroid hormone requires transporter proteins to enter or exit fruit fly cells. The hormone, ecdysone, is called the &#8220;molting hormone.&#8221; Without it, flies will never mature, or reproduce.<\/p>\n<p>Before his discovery, textbooks taught that ecdysone <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/trip-and-travel\/\" data-internallinksmanager029f6b8e52c=\"10\" title=\"Trip &amp; Travel\" target=\"_blank\" rel=\"noopener\">travel<\/a>s freely across cell membranes, slipping past them with ease. &#8220;We now know that&#8217;s not true,&#8221; Yamanaka said. <\/p>\n<p>Every insect species requires ecdysone for some aspect of their journey from egg to offspring-producing adult. And every insect that Yamanaka has tested also possesses the ecdysone transporter that he found in 2018, plus a few more found in a new study. But in this new study, he found mosquitoes to be different. <\/p>\n<p>Mosquitoes have only three of the four transporter proteins that fruit flies possess. They lack the most important, primary ecdysone transporter. <\/p>\n<p>&#8220;This primary one is somehow, mysteriously, missing in mosquitoes,&#8221; Yamanaka said. <\/p>\n<p>These findings have now been published in the <i>Proceedings of the National Academy of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s<\/i>.<\/p>\n<p>The discovery opens the door to a mosquito-specific insecticide that would not harm beneficial bees or other pollinators. It would, however, affect mosquitoes like the ones used in the study, Aedes aegypti, which spread Zika, dengue, yellow fever, chikungunya and other viruses.<\/p>\n<p>&#8220;We can develop chemicals to block the functions of these ecdysone transporters but do not affect the original transporter that is so key for other insects,&#8221; Yamanaka said. &#8220;The chances for off-target effects would be low.&#8221;<\/p>\n<p>A related UC Riverside study, led by cell biologist Sachiko Haga-Yamanaka, is attempting to locate similar hormone transporting machinery in humans. <\/p>\n<p>&#8220;Textbooks say that steroid hormones transport freely into and out of human cells, but based on our insect research, we doubt that to be the case,&#8221; Yamanaka said. <\/p>\n<p>Yamanaka&#8217;s research has been funded by the National Institutes of Health. His laboratory is now screening for chemicals that can block mosquitoes&#8217; ecdysone importers. He is also investigating ecdysone transporters in other animals.<\/p>\n<p>Other methods do exist of ensuring local populations of mosquitoes cannot breed. Releasing sterile, irradiated male mosquitoes into the wild to mate with females results in eggs that do not hatch, a technique that eliminates the need for insecticides. <\/p>\n<p>Though there are effective methods like this for controlling local populations of mosquitoes, Yamanaka feels it is important to develop additional tools so we can handle mosquito-related issues in many different scenarios.<\/p>\n<p>&#8220;It is impossible to make mosquitoes go extinct,&#8221; Yamanaka said. &#8220;Depending on one tool to control them is dangerous. As the climate heats up, it creates even more favorable conditions for them to multiply, and they&#8217;re only likely to become a bigger problem, especially in Southern California.&#8221;<\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            Rewriting the textbook on how steroid hormones enter cells\n                                        <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Lewis V. Hun et al, Essential functions of mosquito ecdysone importers in development and reproduction, <i>Proceedings of the National Academy of Sciences<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1073\/pnas.2202932119\">DOI: 10.1073\/pnas.2202932119<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of California &#8211; Riverside<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.ucr.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Genetic discovery could spell mosquitoes&#8217; death knell (2022, June 15)<br \/>\n                                                 retrieved 15 June 2022<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-06-genetic-discovery-mosquitoes-death-knell.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/phys.org\/news\/2022-06-genetic-discovery-mosquitoes-death-knell.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Genetic discovery could spell mosquitoes&#8217; death knell&#8221; Larval and pupal developmental stages of yellow fever-carrying mosquito. Credit: Lewis Hun\/UCR A UC Riverside genetic discovery could turn disease-carrying mosquitoes into insect Peter Pans, preventing them from ever maturing or multiplying. In 2018, UCR entomologist Naoki Yamanaka found, contrary to accepted scientific wisdom, that an important steroid&#8230;<\/p>\n","protected":false},"author":1,"featured_media":463179,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/genetic-discovery-coul.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-463178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/463178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=463178"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/463178\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/463179"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=463178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=463178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=463178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}