{"id":463639,"date":"2022-06-16T00:00:43","date_gmt":"2022-06-15T21:00:43","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/scientists-reveal-function-of-cell-death-enzyme-capsase-7\/"},"modified":"2022-06-16T00:00:43","modified_gmt":"2022-06-15T21:00:43","slug":"scientists-reveal-function-of-cell-death-enzyme-capsase-7","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/scientists-reveal-function-of-cell-death-enzyme-capsase-7\/","title":{"rendered":"#Scientists reveal function of cell death enzyme capsase-7"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3dbda502596\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3dbda502596\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/scientists-reveal-function-of-cell-death-enzyme-capsase-7\/#%E2%80%9CScientists_reveal_function_of_cell_death_enzyme_capsase-7%E2%80%9D\" >&#8220;Scientists reveal function of cell death enzyme capsase-7&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CScientists_reveal_function_of_cell_death_enzyme_capsase-7%E2%80%9D\"><\/span>&#8220;Scientists reveal function of cell death enzyme capsase-7&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/scientists-reveal-func.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/scientists-reveal-func.jpg\" data-sub-html=\"Capsase-7 illustration. Credit: University of North Carolina School of Medicine\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/scientists-reveal-func.jpg\" alt=\"Scientists reveal function of cell death enzyme capsase-7\" title=\"Capsase-7 illustration. Credit: University of North Carolina School of Medicine\" width=\"600\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Capsase-7 illustration. Credit: University of North Carolina School of Medicine<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Researchers have unmasked a component of the cell death process that could play a vital role in a better infection-fighting strategy.<\/p>\n<section class=\"article-banner first-banner ads-336x280\">\n         <!-- \/4988204\/Phys_Story_InText_Box --><\/p>\n<\/section>\n<p>Scientists at the Duke University School of Medicine and the UNC School of Medicine partnered with researchers at the University of Virginia to identify the function behind caspase-7, an enzyme that is part of a cell&#8217;s self-destruct program. While researchers have known the enzyme is involved in the process, its exact function has been unclear.<\/p>\n<p>The findings are published June 15 in the journal <i>Nature<\/i>.<\/p>\n<p>The researchers found that caspase-7 kicks off a Rube Goldberg <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/watch-movies-tv-seriess\/\" data-internallinksmanager029f6b8e52c=\"8\" title=\"Watch Movies &amp; TV Series\" target=\"_blank\" rel=\"noopener\">series<\/a> of events that allow the cell to die in an orderly fashion, said the study&#8217;s senior author, Edward Miao, MD, Ph.D., a professor in the departments of Immunology and Molecular Genetics and Microbiology at Duke and previously an associate professor in the UNC Department of Microbiology &amp; Immunology.<\/p>\n<p>An orderly cell death is essential for the immune response. Without the enzyme, however, the dying cell might violently explode and cause collateral damage.<\/p>\n<p>Miao said this research lays groundwork to explore exciting possibilities for therapeutic <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>lications, especially if caspase-7 can be boosted or blocked.<\/p>\n<p>&#8220;There is still so much we need to understand about the basic components of our cells, what they do and why,&#8221; Miao said. &#8220;If we can uncover this blueprint, it may become a map for understanding how disease moves in the body, allowing scientists to devise a more precise plan of action. With the discovery of caspase-7&#8217;s role in the cell, we&#8217;re one step closer to a complete schematic.&#8221;<\/p>\n<p>In the study, the researchers found that caspase-7 serves as a timing device in cell death. It activates a protein, called acid sphingomyelinase or ASM, which kicks off a cell membrane repair mechanism, which in turn gives the cell enough time to get its affairs in order before dying.<\/p>\n<p>To identify the function of the caspase-7 enzyme, the team studied different infection models in genetically altered mice and cultured intestinal tissue. They looked at caspase-7&#8217;s role in two types of orderly cell death\u2014extrusion and apoptosis.<\/p>\n<p>Caspase-7&#8217;s role was different in the context of different pathogens\u2014Salmonella, Listeria, and a rare pathogen called Chromobacterium.<\/p>\n<p>With Salmonella, cells undergo an orderly manner of cell death called extrusion. In this context, researchers found the absence of caspase-7 caused the unnecessary death of healthy cells, which were the collateral damage of nearby infected cells failing to detach themselves, or extrude, from their neighbors.<\/p>\n<p>With Chromobacterium and Listeria, dying cells normally undergo a process called apoptosis, or programmed cell death. The lack of caspase-7 enabled the bacteria to survive an immune system attack, presumably because their infected cell host didn&#8217;t accomplish some apoptotic task before exploding.<\/p>\n<p>If caspase-7 can be manipulated, Miao said a potential application is investigating the possibility of targeting the enzyme as a detonator of cell death to circumvent antibiotic resistance.<\/p>\n<p>Antibiotics are a standard and broad approach for fighting infection, but pathogens have devised strategies to adapt and resist.<\/p>\n<p>&#8220;Antibiotics don&#8217;t take into account that each pathogen has its own strategy\u2014some of them are living outside cells, some are living inside cells. If a pathogen is inside the cell,&#8221; he said, &#8220;you could boost caspase-7 to allow the infected cell to die in the correct way. If you know the strategy that the pathogen is using, you can help the immune system by tweaking it in the correct direction.&#8221;<\/p>\n<p>&#8220;On the other hand, if you have a pathogen <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/trip-and-travel\/\" data-internallinksmanager029f6b8e52c=\"10\" title=\"Trip &amp; Travel\" target=\"_blank\" rel=\"noopener\">travel<\/a>ing outside of the cell, and cells are exploding inappropriately, maybe we could boost caspase-7 to keep them alive, thereby prevent excessive damage,&#8221; Miao said, noting that this approach might be effective against sepsis.<\/p>\n<p>Miao said this enzyme could also potentially play a major role in triggering the immune system to fight cancer.<\/p>\n<p>&#8220;Cancer cells are probably running the full Rube Goldberg machine and dying in an orderly manner,&#8221; Miao said. &#8220;When the immune system comes and looks around, it sees that everything seems to be in order and then leaves.<\/p>\n<p>&#8220;If you could shut down the Rube Goldberg contraption, instead of putting itself away nice and neat, the tumor cell would be just dead on the floor,&#8221; Miao said. &#8220;This might cause the immune system to become alarmed and activated. Theoretically, that could cause the immune system to attack a tumor it would otherwise ignore.&#8221;<\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/medicalxpress.com\/news\/2022-04-handbrake-immune-cells-supercharge-immunity.html\">Could releasing &#8216;handbrake&#8217; immune cells help supercharge immunity?<\/a>\n                                        <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Kengo Nozaki et al, Caspase-7 activates ASM to repair gasdermin and perforin pores, <i>Nature<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s41586-022-04825-8\">DOI: 10.1038\/s41586-022-04825-8<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    University of North Carolina School of Medicine<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.med.unc.edu\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/phys.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Scientists reveal function of cell death enzyme capsase-7 (2022, June 15)<br \/>\n                                                 retrieved 16 June 2022<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-06-scientists-reveal-function-cell-death.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/phys.org\/news\/2022-06-scientists-reveal-function-cell-death.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Scientists reveal function of cell death enzyme capsase-7&#8221; Capsase-7 illustration. Credit: University of North Carolina School of Medicine Researchers have unmasked a component of the cell death process that could play a vital role in a better infection-fighting strategy. Scientists at the Duke University School of Medicine and the UNC School of Medicine partnered with&#8230;<\/p>\n","protected":false},"author":1,"featured_media":463640,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/scientists-reveal-func.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-463639","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/463639","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=463639"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/463639\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/463640"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=463639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=463639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=463639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}