{"id":467222,"date":"2022-06-24T21:00:05","date_gmt":"2022-06-24T18:00:05","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/porous-cells-lead-to-poorer-livers\/"},"modified":"2022-06-24T21:00:05","modified_gmt":"2022-06-24T18:00:05","slug":"porous-cells-lead-to-poorer-livers","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/porous-cells-lead-to-poorer-livers\/","title":{"rendered":"#Porous cells lead to poorer livers"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3bf7250c065\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3bf7250c065\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/porous-cells-lead-to-poorer-livers\/#%E2%80%9CPorous_cells_lead_to_poorer_livers%E2%80%9D\" >&#8220;Porous cells lead to poorer livers&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CPorous_cells_lead_to_poorer_livers%E2%80%9D\"><\/span>&#8220;Porous cells lead to poorer livers&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/porous-cells-lead-to-p.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/porous-cells-lead-to-p.jpg\" data-sub-html=\"High-fat diets weaken gut barrier function, resulting in the migration and accumulation of lipoteichoic acid in the liver. The accumulated lipoteichoic acid stimulates the cleavage of gasdermin D protein, forming cell membrane pores where the SASP factors IL-1\u03b2 and IL-33 are released from hepatic stellate cells. IL-33 activates regulatory T cells that suppress immune response, accelerating cancer development. Credit: Osaka Metropolitan University\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/porous-cells-lead-to-p.jpg\" alt=\"Porous cells lead to poorer livers\" title=\"High-fat diets weaken gut barrier function, resulting in the migration and accumulation of lipoteichoic acid in the liver. The accumulated lipoteichoic acid stimulates the cleavage of gasdermin D protein, forming cell membrane pores where the SASP factors IL-1\u03b2 and IL-33 are released from hepatic stellate cells. IL-33 activates regulatory T cells that suppress immune response, accelerating cancer development. Credit: Osaka Metropolitan University\" width=\"800\" height=\"450\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                High-fat diets weaken gut barrier function, resulting in the migration and accumulation of lipoteichoic acid in the liver. The accumulated lipoteichoic acid stimulates the cleavage of gasdermin D protein, forming cell membrane pores where the SASP factors IL-1\u03b2 and IL-33 are released from hepatic stellate cells. IL-33 activates regulatory T cells that suppress immune response, accelerating cancer development. Credit: Osaka Metropolitan University<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Need another reason to think twice before ordering that extra helping of fries? It could lead to a higher risk of developing liver cancer. Cases of nonalcoholic steatohepatitis (NASH)\u2014a type of fatty liver disease that might also lead to cancer\u2014are on the rise, and treatment remains elusive. A research group led by Osaka Metropolitan University took a potential step toward suppression and treatment of NASH-associated liver cancer with their research using obese mice that explains the importance of secreted proteins from cell membrane pores formed in cells in the vicinity of cancer cells in the tumor microenvironment for cancer development. Their findings were published in <i><a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a> Immunology<\/i>.\n                                                <\/p>\n<p>                                                                                While cancer cells themselves are obviously detrimental, neighboring cells including cancer-associated fibroblasts in a so-called &#8220;tumor microenvironment&#8221; can play a part in cancer development as well. &#8220;In the obesity-associated liver tumor microenvironment, the fibroblasts called &#8216;hepatic stellate cells&#8217; become senescent,&#8221; explained lead researcher Professor Naoko Ohtani. &#8220;This causes them to exhibit a senescence-associated secretory phenotype (SASP), where they release a set of proteins that promote cancer by suppressing anti-tumor immunity.&#8221; The mechanism by which proteins such as SASP factors are released and accelerate tumor development remains unclear.<\/p>\n<p>Professor Ohtani&#8217;s team attempted to uncover this mechanism by feeding a high-fat diet to cancer-prone mice and studying the obesity-induced liver cancer. They first conducted a comprehensive gene expression analysis to determine what SASP factors were produced by hepatic stellate cells and then investigated how they were released.<\/p>\n<p>The SASP factors IL-1\u03b2 and IL-33 were discovered to be two of the key facilitators of liver cancer growth. Their release occurs in two main stages. &#8220;First, the high-fat diet weakens gut barrier function, resulting in the migration and accumulation of lipoteichoic acid in the liver,&#8221; Professor Ohtani elaborated. &#8220;Second, the accumulated lipoteichoic acid stimulates the cleavage of gasdermin D protein. This, in turn, forms cell membrane pores where IL-1\u03b2 and IL-33 are exported or released from hepatic stellate cells.&#8221;<\/p>\n<p>These pores play a crucial role, because once IL-33 is released, it activates its receptor-positive regulatory T cells that act to suppress the immune response to cancer cells and potentially exacerbate cancer development.<\/p>\n<p>Understanding this mechanism is an important advance in humanity&#8217;s battle against cancer. &#8220;Our study revealed a very interesting mechanism by which the tumor-promoting SASP factors are released through the cell membrane pores formed by the stimulation of gut microbial component,&#8221; concluded Professor Ohtani. &#8220;Inhibiting this pore formation may facilitate prevention and therapeutic strategies for NASH-associated liver cancer patients.&#8221;\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        A novel function of noncoding RNA in senescence and cancer\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Ryota Yamagishi et al, Gasdermin D\u2013<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/social-mediaa\/\" data-internallinksmanager029f6b8e52c=\"1\" title=\"Social Media\" target=\"_blank\" rel=\"noopener\">media<\/a>ted release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma, <i>Science Immunology<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1126\/sciimmunol.abl7209\">DOI: 10.1126\/sciimmunol.abl7209<\/a>. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.abl7209\">www.science.org\/doi\/10.1126\/sciimmunol.abl7209<\/a><\/p><\/div>\n<p>\n                                                Provided by<br \/>\n                                                                                                    Osaka Metropolitan University<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Porous cells lead to poorer livers (2022, June 24)<br \/>\n                                                 retrieved 24 June 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-06-porous-cells-poorer-livers.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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The accumulated lipoteichoic acid stimulates the cleavage of gasdermin D protein, forming cell membrane pores where the SASP factors IL-1\u03b2 and IL-33 are released from hepatic stellate cells. IL-33 activates regulatory&#8230;<\/p>\n","protected":false},"author":1,"featured_media":467223,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/porous-cells-lead-to-p.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-467222","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/467222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=467222"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/467222\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/467223"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=467222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=467222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=467222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}