{"id":470105,"date":"2022-07-03T12:40:26","date_gmt":"2022-07-03T09:40:26","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/researchers-develop-rapid-covid-19-test-to-identify-variants-in-hours\/"},"modified":"2022-07-03T12:40:26","modified_gmt":"2022-07-03T09:40:26","slug":"researchers-develop-rapid-covid-19-test-to-identify-variants-in-hours","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/researchers-develop-rapid-covid-19-test-to-identify-variants-in-hours\/","title":{"rendered":"#Researchers develop rapid COVID-19 test to identify variants in hours"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a287028cf40b\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a287028cf40b\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/researchers-develop-rapid-covid-19-test-to-identify-variants-in-hours\/#%E2%80%9CResearchers_develop_rapid_COVID-19_test_to_identify_variants_in_hours%E2%80%9D\" >&#8220;Researchers develop rapid COVID-19 test to identify variants in hours&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CResearchers_develop_rapid_COVID-19_test_to_identify_variants_in_hours%E2%80%9D\"><\/span>&#8220;Researchers develop rapid COVID-19 test to identify variants in hours&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/utsw-researchers-devel.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/utsw-researchers-devel.jpg\" data-sub-html=\"Jeffrey SoRelle, M.D. Credit: UT Southwestern Medical Center\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/utsw-researchers-devel.jpg\" alt=\"UTSW researchers develop rapid COVID-19 test to identify variants in hours\" title=\"Jeffrey SoRelle, M.D. Credit: UT Southwestern Medical Center\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Jeffrey SoRelle, M.D. Credit: UT Southwestern Medical Center<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Last year, pathologist Jeffrey SoRelle, M.D., and colleagues developed CoVarScan, a rapid COVID-19 test that detects the signatures of eight hotspots on the SARS-CoV-2 virus. Now, after testing CoVarScan on more than 4,000 patient samples collected at UT Southwestern, the team reports in <i>Clinical Chemistry<\/i> that their test is as accurate as other methods used to diagnose COVID-19 and can successfully differentiate between all current variants of SARS-CoV-2.<\/p>\n<p>                                                                                                                        &#8220;Using this test, we can determine very quickly what variants are in the community and if a new variant is emerging,&#8221; said Dr. SoRelle, Assistant Professor of Pathology and senior author of the study. &#8220;It also has implications for individual patients when we&#8217;re dealing with variants that respond differently to treatments.&#8221;<\/p>\n<p>The testing results at UT Southwestern&#8217;s Once Upon a Time Human Genomics Center have helped public health leaders track the spread of COVID-19 in North Texas and make policy decisions based on the prevalence of variants.  Doctors have also used the results to choose monoclonal antibodies that are more effective against certain strains infecting critically ill COVID-19 patients.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\">\n    <meta itemprop=\"name\" content=\"Researchers develop rapid COVID-19 test to identify variants in hours\"\/><br \/>\n    <meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=bi6wViFKxLw\"\/><br \/>\n    <meta itemprop=\"description\" content=\"Credit: UT Southwestern Medical Center\"\/><br \/>\n    <meta itemprop=\"uploadDate\" content=\"2022-07-03T05:38:21-04:00\"\/><br \/>\n        <meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/bi6wViFKxLw\"\/><br \/>\n    <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/bi6wViFKxLw\/maxresdefault.jpg\"\/><\/p>\n<p>             <iframe loading=\"lazy\" title=\"Researchers develop rapid COVID-19 test to identify variants in hours\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/bi6wViFKxLw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><figcaption class=\"text-darken text-low-up mt-4\" itemprop=\"caption\">Credit: UT Southwestern Medical Center<\/figcaption><\/figure>\n<p>While a number of other tests for COVID-19 exist, they <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/general\/\" data-internallinksmanager029f6b8e52c=\"3\" title=\"General\" target=\"_blank\" rel=\"noopener\">general<\/a>ly detect either a fragment of SARS-CoV-2 genetic material or small molecules found on the surface of the virus, and don&#8217;t provide information to identify the variant. In addition, many researchers worry that these tests aren&#8217;t accurate in detecting some variants\u2014or may miss future strains. To determine which variant of COVID-19 a patient has, scientists typically must use whole genome sequencing, which is time-consuming and expensive, relying on sophisticated equipment and analysis to spell out the entire RNA sequence contained in the viruses.<\/p>\n<p>In early 2021, Dr. SoRelle and his colleagues at UT Southwestern wanted to track how well current tests were detecting emerging variants of SARS-CoV-2. But they realized that sequencing a lot of specimens would not be timely or cost-effective, so they designed their own test, working in the McDermott Center Next Generation Sequencing Core, part of the Eugene McDermott Center for Human Growth and Development directed by Helen Hobbs, M.D., Professor of Internal Medicine and Molecular Genetics.<br \/>\n                                            <!-- Google middle Adsense block --><\/p>\n<p>CoVarScan hones in on eight regions of SARS-CoV-2 that commonly differ between viral variants. It detects small mutations\u2014where the sequence of RNA building blocks varies\u2014and measures the length of repetitive genetic regions that tend to grow and shrink as the virus evolves. The method relies on polymerase chain reaction (PCR)\u2014a technique common in most pathology labs\u2014to copy and measure the RNA at these eight sites of interest. <\/p>\n<p>To test how well CoVarScan works, Dr. SoRelle&#8217;s team ran the test on more than 4,000 COVID-19-positive nasal swab samples collected at UT Southwestern from April 2021 to February 2022\u2014from patients both with and without symptoms. The tests were validated with the gold-standard whole genome sequencing, and the results were used by doctors to choose treatments in some critically ill COVID-19 patients.  <\/p>\n<p>Compared to whole genome sequencing, CoVarScan had 96% sensitivity and 99% specificity. It identified and differentiated Delta, Mu, Lambda, and Omicron variants of COVID-19, including the BA.2 version of Omicron, once known as &#8220;stealth Omicron&#8221; because it did not show up on some tests designed to detect only the Omicron strain.<\/p>\n<p>&#8220;A common critique of this kind of test is that it requires constant adjustment for new variants, but CoVarScan has not needed any adjustment in more than a year; it is still performing very well,&#8221; said Dr. SoRelle. &#8220;In the future, if we did need to adjust it, we could easily add as many as 20 or 30 additional hotspots to the test.&#8221;<\/p>\n<p>Dr. SoRelle plans to continue developing CoVarScan as a commercial test and has a pending patent <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>lication based on this work. As the inventor of the genotyping PCR test for variants, Dr. SoRelle is entitled to income from its use.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Scientist explains genome sequencing of SARS-CoV-2\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Andrew E. Clark et al, Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern, <i>Clinical Chemistry<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1093\/clinchem\/hvac081\">DOI: 10.1093\/clinchem\/hvac081<\/a> , <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1093\/clinchem\/hvac081\">doi.org\/10.1093\/clinchem\/hvac081<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    UT Southwestern Medical Center<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www8.utsouthwestern.edu\/index.html\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Researchers develop rapid COVID-19 test to identify variants in hours (2022, July  3)<br \/>\n                                                 retrieved  3 July 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-07-rapid-covid-variants-hours.html<\/p>\n<p>                                            This document is subject to copyright. 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Now, after testing CoVarScan on more than 4,000 patient samples collected at&#8230;<\/p>\n","protected":false},"author":1,"featured_media":470106,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/utsw-researchers-devel.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-470105","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/470105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=470105"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/470105\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/470106"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=470105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=470105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=470105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}