{"id":473504,"date":"2022-07-13T12:00:01","date_gmt":"2022-07-13T09:00:01","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/research-team-identifies-a-molecular-code-embedded-in-protein-for-regulating-its-glycosylation\/"},"modified":"2022-07-13T12:00:01","modified_gmt":"2022-07-13T09:00:01","slug":"research-team-identifies-a-molecular-code-embedded-in-protein-for-regulating-its-glycosylation","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/research-team-identifies-a-molecular-code-embedded-in-protein-for-regulating-its-glycosylation\/","title":{"rendered":"#Research team identifies a molecular code embedded in protein for regulating its glycosylation"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a295aadc8372\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a295aadc8372\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/research-team-identifies-a-molecular-code-embedded-in-protein-for-regulating-its-glycosylation\/#%E2%80%9CResearch_team_identifies_a_molecular_code_embedded_in_protein_for_regulating_its_glycosylation%E2%80%9D\" >&#8220;Research team identifies a molecular code embedded in protein for regulating its glycosylation&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CResearch_team_identifies_a_molecular_code_embedded_in_protein_for_regulating_its_glycosylation%E2%80%9D\"><\/span>&#8220;Research team identifies a molecular code embedded in protein for regulating its glycosylation&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/sugar-code-in-protein.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/sugar-code-in-protein.jpg\" data-sub-html=\"Specific 29-amino-acid sequence from LAMP-1 serves as a \u201cLewis X code,\u201d which is deciphered by FUT9, and it can be embedded into erythropoietin to evoke Lewis X modification. Credit: Nagoya City University Graduate School of Pharmaceutical Sciences\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/sugar-code-in-protein.jpg\" alt=\"Sugar code in protein\" title=\"Specific 29-amino-acid sequence from LAMP-1 serves as a \u201cLewis X code,\u201d which is deciphered by FUT9, and it can be embedded into erythropoietin to evoke Lewis X modification. Credit: Nagoya City University Graduate School of Pharmaceutical Sciences\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Specific 29-amino-acid sequence from LAMP-1 serves as a \u201cLewis X code,\u201d which is deciphered by FUT9, and it can be embedded into erythropoietin to evoke Lewis X modification. Credit: Nagoya City University Graduate School of Pharmaceutical <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Many proteins in nature exist as glycoproteins, which consist of protein (polypeptide chain) and glycan (sugar chain). The protein structure is determined on the basis of its genetic blueprint, but the information on glycans is not directly encoded by the genome. Therefore, it is difficult to control protein glycosylation.<\/p>\n<p>                                                                                    Under these circumstances, a collaborative research group, including researchers at Nagoya City University, National Institutes of Natural Sciences, and Academia Sinica has found a specific amino acid sequence in a polypeptide that induces a specific glycan structure called Lewis X. The researchers in Japan have previously shown that Lewis X specifically modifies the protein LAMP-1 in mouse neural stem cells through the enzymatic action of fucosyltransferase 9 (FUT9). <\/p>\n<p>In this most recent study published in <i>Communications Biology<\/i>, they have shown that Lewis X modification specific for LAMP-1 occurs not only in neural stem cells but also in several cultured mammalian cells. Furthermore, they have found that a sequence consisting of 29-amino-acid residues in LAMP-1 promotes Lewis X modification catalyzed by the enzyme, and this sequence induces Lewis X modification when fused to other proteins used as biopharmaceuticals. This means that in glycoprotein molecules, a specific amino-acid sequence can determine their glycan structures. <\/p>\n<p>Most biopharmaceuticals are glycoproteins, as best exemplified by therapeutic antibodies. Their glycan structures are critical for their efficacy and safety. Therefore, the control of glycosylation is an important issue in the development of biopharmaceuticals. These findings on a regulatory code of protein glycosylation are expected to pave the way for controlling glycosylation of biopharmaceuticals.<\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                            A winning combination for glycoprotein synthesis\n                                        <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9, <i>Communications Biology<\/i> (2022). <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1038\/s42003-022-03616-1\">DOI: 10.1038\/s42003-022-03616-1<\/a><\/p><\/div>\n<p>                                                Provided by<br \/>\n                                                                                                    Nagoya City University<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Research team identifies a molecular code embedded in protein for regulating its glycosylation (2022, July 13)<br \/>\n                                                 retrieved 13 July 2022<br \/>\n                                                 from https:\/\/phys.org\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-07-team-molecular-code-embedded-protein.html<\/p>\n<p>                                            This document is subject to copyright. 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Credit: Nagoya City University Graduate School of Pharmaceutical Sciences Many proteins in nature exist&#8230;<\/p>\n","protected":false},"author":1,"featured_media":473505,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/sugar-code-in-protein.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-473504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/473504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=473504"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/473504\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/473505"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=473504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=473504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=473504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}