{"id":480036,"date":"2022-08-01T16:12:56","date_gmt":"2022-08-01T13:12:56","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/black-cardamom-bioactives-effective-against-lung-cancer-cells\/"},"modified":"2022-08-01T16:12:56","modified_gmt":"2022-08-01T13:12:56","slug":"black-cardamom-bioactives-effective-against-lung-cancer-cells","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/black-cardamom-bioactives-effective-against-lung-cancer-cells\/","title":{"rendered":"#Black cardamom bioactives effective against lung cancer cells"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3c5705bb4b1\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3c5705bb4b1\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/black-cardamom-bioactives-effective-against-lung-cancer-cells\/#%E2%80%9CBlack_cardamom_bioactives_effective_against_lung_cancer_cells%E2%80%9D\" >&#8220;Black cardamom bioactives effective against lung cancer cells&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CBlack_cardamom_bioactives_effective_against_lung_cancer_cells%E2%80%9D\"><\/span>&#8220;Black cardamom bioactives effective against lung cancer cells&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/nus-study-black-cardam.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/nus-study-black-cardam.jpg\" data-sub-html=\"Comparison of lung cancer cells being treated with 0\u00b5G\/ml, and 150 \u00b5G\/ml of black cardamom extracts over 24 and 48 hour durations. Lung cancer cells showed distorted morphologies with dichloromethane extract treatment. Credit: National University of Singapore\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/nus-study-black-cardam.jpg\" alt=\"NUS study: Black cardamom effective against lung cancer cells\" title=\"Comparison of lung cancer cells being treated with 0\u00b5G\/ml, and 150 \u00b5G\/ml of black cardamom extracts over 24 and 48 hour durations. Lung cancer cells showed distorted morphologies with dichloromethane extract treatment. Credit: National University of Singapore\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Comparison of lung cancer cells being treated with 0\u00b5G\/ml, and 150 \u00b5G\/ml of black cardamom extracts over 24 and 48 hour durations. Lung cancer cells showed distorted morphologies with dichloromethane extract treatment. Credit: National University of Singapore<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>The main challenges associated with existing lung cancer drugs are severe side effects and drug resistance. There is hence a constant need to explore new molecules for improving the survival rate and quality of life of lung cancer patients.\n                                                <\/p>\n<p>                                                                                In Indian Ayurvedic medicine, black cardamom has been used in formulations to treat cancer and lung conditions. A team of researchers from the NUS Faculty of <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>, NUS Yong Loo Lin School of Medicine, and NUS College of Design and Engineering studied the scientific basis behind this traditional medicinal practice and provided evidence of the cytotoxic effect of black cardamom on lung cancer cells. The research highlighted the spice as a source of potent bioactives, such as cardamonin and alpinetin, which could be used in the treatment or prevention of lung cancer. The study is the first to report the association of black cardamom extract with oxidative stress induction in lung cancer cells, and compare the spice&#8217;s effects on lung, breast and liver cancer cells.<\/p>\n<p>The findings could potentially lead to the discovery of safe and effective new bioactives which can prevent or cure cancer formation. The research was first published in the <i>Journal of Ethnopharmacology<\/i> in December 2021.<\/p>\n<p><b>Delving into the science behind Ayurveda<\/b><\/p>\n<p>The research provides the verification of ethnomedical uses of black cardamom for its effect on lung-related conditions. Black cardamom is typically used in Asian households in rice preparations, curries and stews either as a whole spice or in powdered form. The spice is also prescribed in Indian Ayurvedic medicine in powder form where it is used for conditions such as cough, lung congestion, pulmonary tuberculosis, and throat diseases. In addition, black cardamom has been used in medicine formulations for cancer patients in some rural and tribal cultures in India.<\/p>\n<p>In the NUS study, black cardamom fruits were powdered and sequentially extracted with five types of solvents, including organic solvents and water. This allowed the researchers to evaluate the best solvents to extract the most potent actives in the fruit. The various types of black cardamom extracts were then tested for their cytotoxicity against several types of cancer cells. These included cancer cells from the lung, liver and breast. Among the three types of cells, lung cancer cells were least likely to survive when tested with the black cardamom extracts.<br \/>\n                                            <!-- Google middle Adsense block --><\/p>\n<p>&#8220;The study lays the foundation for further study on whether consuming black cardamom can prevent, or help as a therapeutic for, lung cancer. Previous research papers on black cardamom&#8217;s effects on cancer were preliminary and did not link research findings with the use of black cardamom in traditional medicine. There was also not enough screening done using different cancer cells to understand which cancer cells were most responsive to black cardamom extracts,&#8221; said Pooja Makhija, a doctoral student from the Department of Chemistry at NUS Faculty of Science.<\/p>\n<p>The sequential extraction method using hexane followed by dichloromethane produced a black cardamom extract that was most effective against lung cancer cells. Dichloromethane extract treated cells were found to be killed mainly by apoptotic pathway where the measure of live cells, dropped to less than an average of about 20 percent after 48 hours of contact with the black cardamom extracted using dichloromethane. Cell death was caused by apoptosis with cells displaying morphological changes, such as shape distortion and shrinkage, increased oxidative stress, and a failure in DNA damage repair.<\/p>\n<p>After running the black cardamom extract though liquid chromatography mass spectrometry analysis, the researchers linked the presence of two well-researched bioactives, cardamonin and alpinetin, to the cytotoxic potential of black cardamom.<\/p>\n<p>&#8220;With black cardamom being commonly used as an important spice in cooking, further in-depth investigation about its impact on lung cancer progression in the pre-clinical models can provide strong evidence in support of the &#8220;food as medicine&#8221; philosophy of Hippocrates that has been neglected to great extent in the present day,&#8221; said Associate Professor Gautam Sethi from the Department of Pharmacology at the NUS Yong Loo Lin School of Medicine, who was a collaborator for the research.<\/p>\n<p><b>Potential <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>lications for cancer research<\/b><\/p>\n<p>&#8220;The black cardamom extract used in the study can potentially be used to isolate and identify more novel chemical compounds that can be effective against cancer cells. These new actives could then undergo cellular, pre-clinical and clinical testing for further development into drugs for treating cancer,&#8221; said co-principal investigator Adjunct Associate Professor Bert Grobben from Department of Industrial Systems Engineering and Management at the NUS College Design of Engineering.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Cardamonin shows promise for treating aggressive breast cancer\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Pooja Makhija et al, Black cardamom (Amomum subulatum Roxb.) fruit extracts exhibit apoptotic activity against lung cancer cells, <i>Journal of Ethnopharmacology<\/i> (2021).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1016\/j.jep.2021.114953\">DOI: 10.1016\/j.jep.2021.114953<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    National University of Singapore<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.nus.edu.sg\/\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Black cardamom bioactives effective against lung cancer cells (2022, August  1)<br \/>\n                                                 retrieved  1 August 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-08-black-cardamom-bioactives-effective-lung.html<\/p>\n<p>                                            This document is subject to copyright. 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Lung cancer cells showed distorted morphologies with dichloromethane extract treatment. Credit: National University of Singapore The main challenges associated with existing lung cancer drugs are&#8230;<\/p>\n","protected":false},"author":1,"featured_media":480037,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/nus-study-black-cardam.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-480036","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/480036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=480036"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/480036\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/480037"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=480036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=480036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=480036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}