{"id":482651,"date":"2022-08-09T11:06:56","date_gmt":"2022-08-09T08:06:56","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/major-test-of-first-possible-lyme-vaccine-in-20-years-begins\/"},"modified":"2022-08-09T11:06:56","modified_gmt":"2022-08-09T08:06:56","slug":"major-test-of-first-possible-lyme-vaccine-in-20-years-begins","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/major-test-of-first-possible-lyme-vaccine-in-20-years-begins\/","title":{"rendered":"#Major test of first possible Lyme vaccine in 20 years begins"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a407011503fc\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a407011503fc\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/major-test-of-first-possible-lyme-vaccine-in-20-years-begins\/#%E2%80%9CMajor_test_of_first_possible_Lyme_vaccine_in_20_years_begins%E2%80%9D\" >&#8220;Major test of first possible Lyme vaccine in 20 years begins&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CMajor_test_of_first_possible_Lyme_vaccine_in_20_years_begins%E2%80%9D\"><\/span>&#8220;Major test of first possible Lyme vaccine in 20 years begins&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/major-test-of-first-po.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/major-test-of-first-po.jpg\" data-sub-html=\"Robert Terwilliger, right, of Williamsburg, Pa., who is participating in a Lyme disease vaccine trial at the Altoona Center for Clinical Research, is injected with either the new vaccine or a placebo, by registered nurse Janae Roland, Friday, Aug. 5, 2022, in Duncansville, Pa. Lyme is a growing problem, with cases steadily rising and warming weather helping ticks expand their habitat. Credit: AP Photo\/Gary M. Baranec\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/major-test-of-first-po.jpg\" alt=\"Major test of first possible Lyme vaccine in 20 years begins\" title=\"Robert Terwilliger, right, of Williamsburg, Pa., who is participating in a Lyme disease vaccine trial at the Altoona Center for Clinical Research, is injected with either the new vaccine or a placebo, by registered nurse Janae Roland, Friday, Aug. 5, 2022, in Duncansville, Pa. Lyme is a growing problem, with cases steadily rising and warming weather helping ticks expand their habitat. Credit: AP Photo\/Gary M. Baranec\" width=\"800\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Robert Terwilliger, right, of Williamsburg, Pa., who is participating in a Lyme disease vaccine trial at the Altoona Center for Clinical Research, is injected with either the new vaccine or a placebo, by registered nurse Janae Roland, Friday, Aug. 5, 2022, in Duncansville, Pa. Lyme is a growing problem, with cases steadily rising and warming weather helping ticks expand their habitat. Credit: AP Photo\/Gary M. Baranec<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Researchers are seeking thousands of volunteers in the U.S. and Europe to test the first potential vaccine against <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.cdc.gov\/lyme\/index.html\">Lyme disease<\/a> in 20 years\u2014in hopes of better fighting the tick-borne threat.\n                                                <\/p>\n<p>                                                                                Lyme is a <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.cdc.gov\/lyme\/datasurveillance\/index.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Flyme%2Fstats%2Findex.html\">growing problem,<\/a> with cases rising and warming weather helping ticks expand their habitat. While a vaccine for dogs has long been available, the only Lyme vaccine for humans was pulled off the U.S. market in 2002 from lack of demand, leaving people to rely on bug spray and tick checks.<\/p>\n<p>Now Pfizer and French biotech Valneva are aiming to avoid previous pitfalls in developing a new vaccine to protect both adults and kids as young as 5 from the most common Lyme strains on two continents.<\/p>\n<p>&#8220;There wasn&#8217;t such a recognition, I think, of the severity of Lyme disease&#8221; and how many people it affects the last time around, Pfizer vaccine chief Annaliesa Anderson told The Associated Press.<\/p>\n<p>Robert Terwilliger, an avid hunter and hiker, was first in line Friday when the study opened in central Pennsylvania. He&#8217;s seen lots of friends get Lyme and is tired of wondering if his next tick bite will make him sick.<\/p>\n<p>&#8220;It&#8217;s always a worry, you know? Especially when you&#8217;re sitting in a tree stand hunting and you feel something crawling on you,&#8221; said Terwilliger, 60, of Williamsburg, Pennsylvania. &#8220;You&#8217;ve got to be very, very cautious.&#8221;<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/major-test-of-first-po-1.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/major-test-of-first-po-1.jpg\" data-sub-html=\"Away from volunteers participating in a new Lyme disease vaccine trial, registered nurse Janae Roland, prepares either the vaccine or a placebo at the Altoona Center for Clinical Research, Friday, Aug. 5, 2022, in Duncansville, Pa. The Centers for Disease Control and Prevention cites insurance records suggesting 476,000 people are treated for the the tick-borne disease in the U.S. each year. Credit: AP Photo\/Gary M. Baranec\">\n<figure class=\"article-img text-center\">\n            <img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800\/2022\/major-test-of-first-po-1.jpg\" alt=\"Major test of first possible Lyme vaccine in 20 years begins\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                Away from volunteers participating in a new Lyme disease vaccine trial, registered nurse Janae Roland, prepares either the vaccine or a placebo at the Altoona Center for Clinical Research, Friday, Aug. 5, 2022, in Duncansville, Pa. The Centers for Disease Control and Prevention cites insurance records suggesting 476,000 people are treated for the the tick-borne disease in the U.S. each year. Credit: AP Photo\/Gary M. Baranec<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Exactly how often Lyme disease strikes isn&#8217;t clear. The Centers for Disease Control and Prevention cites insurance records suggesting 476,000 people are treated for Lyme in the U.S. each year. Pfizer&#8217;s Anderson put Europe&#8217;s yearly infections at about 130,000.<\/p>\n<p>Black-legged ticks, also called deer ticks, carry Lyme-causing bacteria. The infection initially causes fatigue, fever and joint pain. Often\u2014but not always\u2014the first sign is a red, round bull&#8217;s-eye rash.<\/p>\n<p>Early antibiotic treatment is crucial, but it can be hard for people to tell if they were bitten by ticks, some as small as a pin. Untreated Lyme can cause severe arthritis and damage the heart and nervous system. Some people have lingering symptoms even after treatment.<\/p>\n<p>Most vaccines against other diseases work after people are exposed to a germ. The Lyme vaccine offers a different strategy\u2014working a step earlier to block a tick bite from transmitting the infection, said Dr. Gary Wormser, a Lyme expert at New York Medical College who isn&#8217;t involved with the new research.<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/major-test-of-first-po-2.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/major-test-of-first-po-2.jpg\" data-sub-html=\"Dr. Alan Kivitz, right, a rheumatologist at the Altoona Center for Clinical Research describes future steps involved in a new Lyme disease vaccine trial to Robert Terwilliger of Williamsburg, Pa., who was the first volunteer to receive either the vaccine or a placebo Friday, Aug. 5, 2022, in Duncansville, Pa. Black-legged ticks, also called deer ticks, carry Lyme-causing bacteria. The infection initially causes fatigue, fever and joint pain. Often -- but not always -- the first sign is a red, round bull's-eye rash. Credit: AP Photo\/Gary M. Baranec\">\n<figure class=\"article-img text-center\">\n            <img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800\/2022\/major-test-of-first-po-2.jpg\" alt=\"Major test of first possible Lyme vaccine in 20 years begins\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                Dr. Alan Kivitz, right, a rheumatologist at the Altoona Center for Clinical Research describes future steps involved in a new Lyme disease vaccine trial to Robert Terwilliger of Williamsburg, Pa., who was the first volunteer to receive either the vaccine or a placebo Friday, Aug. 5, 2022, in Duncansville, Pa. Black-legged ticks, also called deer ticks, carry Lyme-causing bacteria. The infection initially causes fatigue, fever and joint pain. Often &#8212; but not always &#8212; the first sign is a red, round bull&#8217;s-eye rash. Credit: AP Photo\/Gary M. Baranec<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>How? It targets an &#8220;outer surface protein&#8221; of the Lyme bacterium called OspA that&#8217;s present in the tick&#8217;s gut. It&#8217;s estimated a tick must feed on someone for about 36 hours before the bacteria spreads to its victim. That delay gives time for antibodies the tick ingests from a vaccinated person&#8217;s blood to attack the germs right at the source.<br \/>\n                                            <!-- Google middle Adsense block --><\/p>\n<p>In small, early-stage studies, Pfizer and Valneva reported no safety problems and a good immune response. The newest study will test if the vaccine, called VLA15, really protects and is safe. The companies aim to recruit at least 6,000 people in Lyme-prone areas including the Northeast U.S. plus Finland, Germany, the Netherlands, Poland and Sweden.<\/p>\n<p>They&#8217;ll receive three shots, either the vaccine or a placebo, between now and next spring&#8217;s tick season. A year later, they&#8217;ll get a single booster dose.<\/p>\n<p>&#8220;We&#8217;re really looking at something that&#8217;s a seasonal vaccine,&#8221; Anderson said, so people have high antibody levels during the months when ticks are most active.<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/major-test-of-first-po-3.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/major-test-of-first-po-3.jpg\" data-sub-html=\"Janae Roland, a registered nurse at the Altoona Center for Clinical Research begins the process of preparing refrigerated doses of a new Lyme disease vaccine Friday, Aug. 5, 2022, in Duncansville, Pa. Credit: AP Photo\/Gary M. Baranec\">\n<figure class=\"article-img text-center\">\n            <img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800\/2022\/major-test-of-first-po-3.jpg\" alt=\"Major test of first possible Lyme vaccine in 20 years begins\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                Janae Roland, a registered nurse at the Altoona Center for Clinical Research begins the process of preparing refrigerated doses of a new Lyme disease vaccine Friday, Aug. 5, 2022, in Duncansville, Pa. Credit: AP Photo\/Gary M. Baranec<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>Volunteers can be as young as 5 and should be at high risk because they spend a lot of time in tick-infested areas, such as hikers, campers and hunters, said Dr. Alan Kivitz who heads one of the study sites at Altoona Center for Clinical Research in Duncansville, Pennsylvania.<\/p>\n<p>In his own practice, &#8220;not a single day goes by that someone either has a concern about Lyme disease, could possibly have Lyme disease,&#8221; Kivitz said.<\/p>\n<p>This new candidate is different from a previous Lyme vaccine that GlaxoSmithKline pulled off the market in 2002 amid controversy and low sales. With about 75% effectiveness, that old Lyme shot got a lukewarm endorsement from vaccine experts, wasn&#8217;t tested in children and drew unsubstantiated reports of joint-related side effects.<\/p>\n<p>While the new Pfizer-Valneva vaccine also targets the OspA protein, it&#8217;s engineered somewhat differently than its predecessor and also targets six Lyme strains in the U.S. and Europe instead of just one.<\/p>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/major-test-of-first-po-4.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/major-test-of-first-po-4.jpg\" data-sub-html=\"Away from volunteers participating in a new Lyme disease vaccine trial registered nurse Janae Roland, at the Altoona Center for Clinical Research prepares either the vaccine or a placebo Friday, Aug. 5, 2022, in Duncansville, Pa. Credit: AP Photo\/Gary M. Baranec\">\n<figure class=\"article-img text-center\">\n            <img decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800\/2022\/major-test-of-first-po-4.jpg\" alt=\"Major test of first possible Lyme vaccine in 20 years begins\"\/><figcaption class=\"text-left text-darken text-truncate text-low-up mt-3\">\n                Away from volunteers participating in a new Lyme disease vaccine trial registered nurse Janae Roland, at the Altoona Center for Clinical Research prepares either the vaccine or a placebo Friday, Aug. 5, 2022, in Duncansville, Pa. Credit: AP Photo\/Gary M. Baranec<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>The Pfizer study will span two tick seasons to get answers\u2014but it&#8217;s not the only research into new ways to prevent Lyme. University of Massachusetts scientists are working on a vaccine alternative, shots of pre-made Lyme-fighting antibodies.<\/p>\n<p>And Yale University researchers are in early stages of designing a vaccine that recognizes a tick&#8217;s saliva\u2014which in animal testing sparked a skin reaction that made it harder for ticks to hang on and feed.<\/p>\n<p>Since different tick species carry many diseases other than Lyme, ultimately &#8220;we&#8217;re all hoping for a tick-bite prevention vaccine,&#8221; Wormser said.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Research into preventive shot for Lyme disease continues to move forward\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<p class=\"article-main__note mt-4\">\n                                                \u00a9 2022 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Major test of first possible Lyme vaccine in 20 years begins (2022, August  9)<br \/>\n                                                 retrieved  9 August 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-08-major-lyme-vaccine-years.html<\/p>\n<p>                                            This document is subject to copyright. 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