{"id":482773,"date":"2022-08-09T19:25:03","date_gmt":"2022-08-09T16:25:03","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/two-medication-strategy-offers-both-benefit-and-risk-after-coronary-artery-bypass-surgery\/"},"modified":"2022-08-09T19:25:03","modified_gmt":"2022-08-09T16:25:03","slug":"two-medication-strategy-offers-both-benefit-and-risk-after-coronary-artery-bypass-surgery","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/two-medication-strategy-offers-both-benefit-and-risk-after-coronary-artery-bypass-surgery\/","title":{"rendered":"#Two-medication strategy offers both benefit and risk after coronary artery bypass surgery"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a3bf08b96ec7\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a3bf08b96ec7\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/two-medication-strategy-offers-both-benefit-and-risk-after-coronary-artery-bypass-surgery\/#%E2%80%9CTwo-medication_strategy_offers_both_benefit_and_risk_after_coronary_artery_bypass_surgery%E2%80%9D\" >&#8220;Two-medication strategy offers both benefit and risk after coronary artery bypass surgery&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CTwo-medication_strategy_offers_both_benefit_and_risk_after_coronary_artery_bypass_surgery%E2%80%9D\"><\/span>&#8220;Two-medication strategy offers both benefit and risk after coronary artery bypass surgery&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/heart.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/heart.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/heart.jpg\" alt=\"heart\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"529\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>A new analysis shows that a combination of two anti-platelets drugs can benefit patients after the most common type of cardiac surgery\u2014while also increasing the risk of potentially dangerous bleeding. This double-edged finding from Weill Cornell Medicine and NewYork-Presbyterian investigators suggests physicians should carefully weigh the use of these medications after this procedure.\n                                                <\/p>\n<p>                                                                                In an analysis reported Aug. 9 in <i>JAMA<\/i>, a team led by Dr. Mario Gaudino, a coronary artery bypass surgeon, examined data from 1,668 grafts in which surgeons use a piece of vein taken from the leg to circumvent blocked coronary arteries. Sometimes, however, blood clots form within the grafted vein, obstructing blood flow. Typically, patients are given aspirin; however, some evidence suggests that aspirin along with a pre<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">script<\/a>ion strength anti-platelet agent, such as one called ticagrelor, can more effectively prevent this clotting. <\/p>\n<p>&#8220;We found that, yes, this dual therapy significantly reduces the risk that the grafts will fail. However, for the first time, we have shown that this approach also carries a significant risk of clinically important bleeding,&#8221; said Dr. Gaudino, the Stephen and Suzanne Weiss Professor in Cardiothoracic Surgery at Weill Cornell Medicine and a cardiothoracic surgeon at NewYork-Presbyterian\/Weill Cornell Medical Center. &#8220;So, the benefit comes at a price.&#8221;<\/p>\n<p>Taken together, these results indicate physicians should base their decisions on patients&#8217; individual circumstances and avoid using this approach for those with conditions that put them at risk of bleeding, he said.  <\/p>\n<p>Every year, approximately 300,000 patients undergo coronary artery bypass grafts to treat narrowed or blocked arteries that deprive the heart muscle of oxygen-rich blood. In more than 90 percent of these procedures, surgeons take a graft from one of the patient&#8217;s saphenous veins, which carry blood up the inner side of the legs. However, within a year, as many as a quarter of these grafts become obstructed. <\/p>\n<p>Some studies have examined the benefit of giving patients both aspirin and ticagrelor, an approach known as dual antiplatelet therapy (DAPT). However, these studies were small and came to conflicting conclusions. The team, including first author Dr. Sigrid Sandner, a master&#8217;s student in clinical epidemiology at the Weill Cornell Graduate School of Medical <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">Science<\/a>s, reached out to researchers on four such trials to obtain access to their raw data. The team then compiled that data, in effect creating a much larger study capable of generating more robust conclusions. <\/p>\n<p>They found a failure rate of approximately 11 percent in patients who received a combination of aspirin and ticagrelor, while blockages occurred in 20 percent of grafts when patients received only aspirin. However, as compared with aspirin alone, DAPT brought on more bleeding events that, while <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/general\/\" data-internallinksmanager029f6b8e52c=\"3\" title=\"General\" target=\"_blank\" rel=\"noopener\">general<\/a>ly not life threatening, required medical attention. <\/p>\n<p>In these previous trials, patients received DAPT for a full year. However, most graft failure occurs in the first few months after surgery. Next, Dr. Gaudino, who is also director of the Joint Clinical Trials Office at Weill Cornell Medicine and NewYork-Presbyterian, hopes to test aspirin and ticagrelor over one to three months to see if a shortened course offers the same benefit with less risk of bleeding.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Ticagrelor + aspirin beneficial after elective CABG\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Sigrid Sandner et al, Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery, <i>JAMA<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1001\/jama.2022.11966\">DOI: 10.1001\/jama.2022.11966<\/a><\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    Weill Cornell Medical College<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"http:\/\/www.med.cornell.edu\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Two-medication strategy offers both benefit and risk after coronary artery bypass surgery (2022, August  9)<br \/>\n                                                 retrieved  9 August 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-08-two-medication-strategy-benefit-coronary-artery.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. 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This double-edged finding from Weill Cornell Medicine and NewYork-Presbyterian&#8230;<\/p>\n","protected":false},"author":1,"featured_media":482774,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2022\/heart.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-482773","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/482773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=482773"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/482773\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/482774"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=482773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=482773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=482773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}