{"id":485842,"date":"2022-08-19T00:26:04","date_gmt":"2022-08-18T21:26:04","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/when-covid-19-or-flu-viruses-kill-they-often-have-an-accomplice-bacterial-infections\/"},"modified":"2022-08-19T00:26:04","modified_gmt":"2022-08-18T21:26:04","slug":"when-covid-19-or-flu-viruses-kill-they-often-have-an-accomplice-bacterial-infections","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/when-covid-19-or-flu-viruses-kill-they-often-have-an-accomplice-bacterial-infections\/","title":{"rendered":"#When COVID-19 or flu viruses kill, they often have an accomplice\u2014bacterial infections"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a40dd40b300c\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a40dd40b300c\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/when-covid-19-or-flu-viruses-kill-they-often-have-an-accomplice-bacterial-infections\/#%E2%80%9CWhen_COVID-19_or_flu_viruses_kill_they_often_have_an_accomplice%E2%80%94bacterial_infections%E2%80%9D\" >&#8220;When COVID-19 or flu viruses kill, they often have an accomplice\u2014bacterial infections&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CWhen_COVID-19_or_flu_viruses_kill_they_often_have_an_accomplice%E2%80%94bacterial_infections%E2%80%9D\"><\/span>&#8220;When COVID-19 or flu viruses kill, they often have an accomplice\u2014bacterial infections&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2022\/when-covid-19-or-flu-v.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/when-covid-19-or-flu-v.jpg\" data-sub-html=\"Staphylococcus aureus, or MRSA, is a common source of bacterial coinfections. Credit: Janice Haney Car\/Centers for Disease Control and Prevention\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2022\/when-covid-19-or-flu-v.jpg\" alt=\"When COVID-19 or flu viruses kill, they often have an accomplice \u2013 bacterial infections\" title=\"Staphylococcus aureus, or MRSA, is a common source of bacterial coinfections. Credit: Janice Haney Car\/Centers for Disease Control and Prevention\" width=\"754\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Staphylococcus aureus, or MRSA, is a common source of bacterial coinfections. Credit: Janice Haney Car\/Centers for Disease Control and Prevention<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>The <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.cdc.gov\/flu\/pandemic-resources\/1918-pandemic-h1n1.html\">1918 influenza pandemic<\/a> resulted in the loss of over 3% of the world&#8217;s population\u2014at least 50 million people. But it wasn&#8217;t the flu virus that caused the majority of these deaths.\n                                                <\/p>\n<p>                                                                                An <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1086\/591708\">analysis of lung samples<\/a> collected during that flu pandemic indicated that most of the deaths were likely due to bacterial pneumonia, which ran rampant in the absence of antibiotics. Even in more recent history, like the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/S0140-6736(58)90060-6\">1957 H2N2<\/a> and <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1378\/chest.10-1396\">2009 H1N1<\/a> flu pandemics, nearly 18% of patients with viral pneumonia had additional bacterial infections that increased their risk of death. And the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1186\/s41479-021-00083-w\">COVID-19 pandemic<\/a> is no different.<\/p>\n<p>With yet another flu season fast <a href=\"https:\/\/buradabiliyorum.com\/en\/category\/download-scripts-themes-apps\/\" data-internallinksmanager029f6b8e52c=\"9\" title=\"Download Scripts &amp; Themes &amp; Apps\" target=\"_blank\" rel=\"noopener\">app<\/a>roaching in the midst of the ongoing COVID-19 pandemic, lessening the harm caused by these viruses is important to prevent deaths and reduce infections. However, many deaths associated with the flu and COVID-19 don&#8217;t occur at the hand of the virus alone. Instead, it&#8217;s a <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.3390\/v13091725\">secondary bacterial infection<\/a> that is often at the root of the devastating consequences attributed to an initial viral infection.<\/p>\n<p>I am an <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/medicine.tufts.edu\/people\/faculty\/hayley-muendlein\">immunologist<\/a> who studies why and how cells die during bacterial and viral infections. Understanding the synergy between these microbes is critical not only for effective diagnosis and treatment, but also for managing current pandemics and preventing future ones. My colleagues and I <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1073\/pnas.2113872119\">published a study<\/a> showing how an immune system protein crucial to fighting against viruses also plays an indispensable role in fighting bacteria.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\">\n    <meta itemprop=\"name\" content=\"When COVID-19 or flu viruses kill, they often have an accomplice \u2013 bacterial infections\"\/><br \/>\n    <meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=fYYy1ySvAhA\"\/><br \/>\n    <meta itemprop=\"description\" content=\"When COVID-19 or flu viruses kill, they often have an accomplice \u2013 bacterial infections\"\/><br \/>\n    <meta itemprop=\"uploadDate\" content=\"2022-08-18T04:21:02-04:00\"\/><br \/>\n        <meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/fYYy1ySvAhA\"\/><br \/>\n    <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/fYYy1ySvAhA\/maxresdefault.jpg\"\/><\/p>\n<p>             <iframe loading=\"lazy\" title=\"Healthcare community increasingly mindful of possibility of co-infection\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/fYYy1ySvAhA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<\/figure>\n<p><b>Viruses and bacteria team up<\/b><\/p>\n<p>Multiple pathogens can cause multiple infections in different ways. Scientists distinguish each type <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1186\/s41479-021-00083-w\">based on the timing<\/a> of when each infection occurs. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.biomedcentral.com\/collections\/CIS\">Coinfection<\/a> refers to two or more different pathogens causing infections at the same time. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/www.mountsinai.org\/health-library\/special-topic\/secondary-infections#\">Secondary or superinfections<\/a>, on the other hand, refer to sequential infections that occur after an initial infection. They&#8217;re often caused by pathogens resistant to antibiotics used to treat the primary infection.<br \/>\n                                            <!-- Google middle Adsense block --><\/p>\n<p>How viral and bacterial infections interact with each other increases the potential harm they can cause. Viral respiratory infections can increase the likelihood of bacterial infections and lead to worse disease. The reason why this happens is often multifaceted.<\/p>\n<p>Within your respiratory tract, the epithelial cells lining your airways and lungs serve as the first line of defense against inhaled pathogens and debris. However, <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1164\/rccm.200909-1420OC\">viruses can kill these cells<\/a> and disrupt this protective barrier, allowing inhaled bacteria to invade. They can also <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1164\/arrd.1986.134.5.1040\">change the surface of epithelial cells<\/a> to make them easier for bacteria to attach to. <\/p>\n<p>Viruses can also alter the surface of <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1164\/rccm.201406-1101PP\">epithelial and immune cells<\/a> by <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1159\/000335548\">reducing the number of receptors<\/a> that help these cells recognize and mount a response against pathogens. This reduction means fewer immune cells report to the viral infection site, giving bacteria an opening to launch another infection.<\/p>\n<p><b>Influenza, COVID-19 and bacterial infections<\/b><\/p>\n<p>Patients who have a bacterial infection at the same time they&#8217;re battling the seasonal flu are more likely to wind up in a hospital. <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1111\/j.1750-2659.2012.00360.x\">Nearly a quarter<\/a> of patients admitted to the ICU with severe influenza also have a bacterial infection. One study on the 2010 to 2018 flu seasons found that <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.jiac.2018.10.014\">nearly 20% of patients<\/a> admitted to the hospital with flu-associated pneumonia had acquired bacterial infections.<\/p>\n<p><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.eclinm.2021.100955\">Another study<\/a> of patients hospitalized with viral or bacterial infections found that nearly half had a coinfection with another pathogen. These patients also had nearly double the risk of dying within 30 days compared to those with only a single infection. <\/p>\n<p>Interestingly, the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1111\/irv.12398\">two bacteria species<\/a> most commonly involved in coinfections with the influenza virus are <i>Streptococcus pneumoniae<\/i> and <i>Staphylococcus aureus<\/i>, which normally exist in the respiratory tract without causing disease. However, the influenza virus can damage the cell barrier of the lungs and disrupt immune function enough to make patients susceptible to infection by these otherwise benign bacteria.<\/p>\n<p>Secondary bacterial infections are also exacerbating the COVID-19 pandemic. A 2021 review estimated that <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1371\/journal.pone.0251170\">16% to 28% of adults<\/a> hospitalized for COVID-19 also had a bacterial infection. These patients stayed in the hospital for twice as long, were four times more likely to need mechanical ventilation and had three times greater odds of dying compared to patients with only COVID-19.<\/p>\n<figure class=\"mb-4\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/VideoObject\">\n    <meta itemprop=\"name\" content=\"When COVID-19 or flu viruses kill, they often have an accomplice \u2013 bacterial infections\"\/><br \/>\n    <meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=1vaEVcMfa1E\"\/><br \/>\n    <meta itemprop=\"description\" content=\"When COVID-19 or flu viruses kill, they often have an accomplice \u2013 bacterial infections\"\/><br \/>\n    <meta itemprop=\"uploadDate\" content=\"2022-08-18T09:50:40-04:00\"\/><br \/>\n        <meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/1vaEVcMfa1E\"\/><br \/>\n    <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/1vaEVcMfa1E\/maxresdefault.jpg\"\/><\/p>\n<p>             <iframe loading=\"lazy\" title=\"What is Necrosis vs What is Apoptosis?\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/1vaEVcMfa1E?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<\/figure>\n<p><b>Addressing secondary and coinfections<\/b><\/p>\n<p>The immune system <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/courses.lumenlearning.com\/suny-ap2\/chapter\/the-immune-response-against-pathogens\/\">responds differently<\/a> to viruses and bacteria. Antivirals don&#8217;t work on bacteria, and antibiotics don&#8217;t work on viruses. A better understanding of what pathways the body uses to regulate both antiviral and antibacterial infections is critical to addressing secondary and coinfections.<\/p>\n<p><a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1073\/pnas.2113872119\">Recent work<\/a> by my colleagues and me may provide a clue. We <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1101\/pdb.top084970\">sequenced the RNA<\/a> of one type of immune cell, macrophages, in mice to identify what molecules were present in cells that were either protected from or died due to bacterial infection. <\/p>\n<p>We identified <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1007\/82_2019_190\">Z-DNA binding protein (ZBP1)<\/a>, a molecule already known to play a regulatory role in how the immune system responds to influenza. Specifically, ZBP1 <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1007\/82_2019_190\">detects influenza viruses<\/a> within the lungs and signals infected epithelial and immune cells to self-destruct. This induced cell death eliminates the virus and promotes recruitment of additional immune cells to the infection site.<\/p>\n<p>Building off this finding that ZBP1 is important for fighting viral infection, we found that macrophages infected with <i>Yersinia pseudotuberculosis<\/i>, a type of bacteria that causes foodborne illness, also use this protein to initiate <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41467-020-20357-z\">cell death<\/a>. This limits bacterial replication while also sending <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1073\/pnas.2113872119\">inflammatory signals<\/a> that help clear bacteria.<\/p>\n<p>These findings raise the possibility that ZBP1 may play a dual role in how the body responds to viral and bacterial infections. It&#8217;s possible that treatments that increase ZBP1 in certain types of cells may be useful in managing bacterial and viral coinfections.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"text-medium text-info mt-2 d-inline-block\" href=\"https:\/\/phys.org\/news\/2021-01-iron-carrying-extracellular-vesicles-key-respiratory.html\">Iron-carrying extracellular vesicles are key to respiratory viral-bacterial co-infection<\/a>\n                                                                                    <\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"d-inline-block text-medium my-4\">\n                                                Provided by<br \/>\n                                                                                                    The Conversation<br \/>\n                                                                                                        <a rel=\"nofollow noopener\" target=\"_blank\" class=\"icon_open\" href=\"https:\/\/theconversation.com\"><br \/>\n                                                        <svg>\n                                                            <use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n                                                        <\/svg><br \/>\n                                                    <\/a><\/p><\/div>\n<p class=\"article-main__note mt-4\">\n                                                This article is republished from <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\">The Conversation<\/a> under a Creative Commons license. Read the <a rel=\"nofollow noopener\" target=\"_blank\" href=\"https:\/\/theconversation.com\/when-covid-19-or-flu-viruses-kill-they-often-have-an-accomplice-bacterial-infections-187056\">original article<\/a>.<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/counter.theconversation.com\/content\/187056\/count.gif?distributor=republish-lightbox-advanced\" alt=\"The Conversation\" width=\"1\" height=\"1\"\/><\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 When COVID-19 or flu viruses kill, they often have an accomplice\u2014bacterial infections (2022, August 18)<br \/>\n                                                 retrieved 18 August 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-08-covid-flu-viruses-accomplicebacterial-infections.html<\/p>\n<p>                                            This document is subject to copyright. 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Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2022-08-covid-flu-viruses-accomplicebacterial-infections.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;When COVID-19 or flu viruses kill, they often have an accomplice\u2014bacterial infections&#8221; Staphylococcus aureus, or MRSA, is a common source of bacterial coinfections. Credit: Janice Haney Car\/Centers for Disease Control and Prevention The 1918 influenza pandemic resulted in the loss of over 3% of the world&#8217;s population\u2014at least 50 million people. But it wasn&#8217;t the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":485843,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/2022\/when-covid-19-or-flu-v.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-485842","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/485842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=485842"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/485842\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/485843"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=485842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=485842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=485842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}