{"id":487397,"date":"2022-08-24T18:03:02","date_gmt":"2022-08-24T15:03:02","guid":{"rendered":"https:\/\/en.buradabiliyorum.com\/how-different-flavors-of-inhibition-save-the-day\/"},"modified":"2022-08-24T18:03:02","modified_gmt":"2022-08-24T15:03:02","slug":"how-different-flavors-of-inhibition-save-the-day","status":"publish","type":"post","link":"https:\/\/buradabiliyorum.com\/en\/how-different-flavors-of-inhibition-save-the-day\/","title":{"rendered":"#How different flavors of inhibition save the day"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a36e8ac3082f\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #dd3333;color:#dd3333\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #dd3333;color:#dd3333\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a36e8ac3082f\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/buradabiliyorum.com\/en\/how-different-flavors-of-inhibition-save-the-day\/#%E2%80%9CHow_different_flavors_of_inhibition_save_the_day%E2%80%9D\" >&#8220;How different flavors of inhibition save the day&#8221;<\/a><\/li><\/ul><\/nav><\/div>\n<h1><span class=\"ez-toc-section\" id=\"%E2%80%9CHow_different_flavors_of_inhibition_save_the_day%E2%80%9D\"><\/span>&#8220;How different flavors of inhibition save the day&#8221;<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2021\/neuron.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2021\/neuron.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2021\/neuron.jpg\" alt=\"neuron\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"450\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>During development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibitory neuron subtypes are known to influence circuit dynamics, but how they interact with plasticity is not yet fully understood. Scientists at the Max Planck Institute for Brain Research in Frankfurt have investigated how synaptic plasticity in rodents, who were deprived of vision in one eye, affects network activity in a circuit model of the sensory cortex. Their findings point to the role of different inhibitory interneuron subtypes to explain the temporal pattern of firing rate change of excitatory and inhibitory neurons during sensory deprivation.\n                                                <\/p>\n<p>                                                                                Multiple plasticity mechanisms interact and balance each other as they shape neural circuits during their development. A way to visualize the action of these mechanisms is to break the system and observe how it reacts. For decades, experimental neuroscientists have used monocular deprivation, a closure of one eye during specific periods in development. Regardless of its rich tradition in neuro<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/sciencee\/\" data-internallinksmanager029f6b8e52c=\"5\" title=\"Science\" target=\"_blank\" rel=\"noopener\">science<\/a>, the effects of monocular deprivation still leave scientists with many unsolved riddles.<\/p>\n<p>Only recently, experimentalists found that the firing rates of excitatory and inhibitory neurons are regulated in a distinct, cell-type specific manner by the plasticity induced by ongoing monocular deprivation. To investigate how the cell-type specific regulation is achieved, Julijana Gjorgjieva, research group leader at the Max Planck Institute for Brain Research and Professor at TU Munich and her graduate student Leonidas Richter developed a mechanistic model of the cortical circuit to study how the interactions of experimentally observed changes to synapses (the connections between neurons) regulate activity.<\/p>\n<p>&#8220;We found that cell-type specific regulation is not easily achieved in a simple model of excitatory and a single type of inhibitory neurons as it is commonly used in modeling studies. We tied this result to the so-called paradoxical effect, which decreases inhibitory firing rates even when they are driven,&#8221; explains Richter.<\/p>\n<p>The scientists analyzed how this effect plays out with the more complex plasticity induced by monocular deprivation. This allowed them to investigate the conditions for modulating excitatory and inhibitory firing rates in opposite directions. &#8220;We discovered that the diversity of inhibitory interneurons in the cortex is key to capture the regulation of firing rates especially when neurons are strongly connected as is the case in the cortex.&#8221;<\/p>\n<p>&#8220;Diverse interneurons are known to play important specific roles in cortical computations. Our findings suggest that they also have a key role already in the development of the circuitry underlying these computations,&#8221; says Gjorgjieva.<\/p>\n<p>The research was published in <i>Proceedings of the National Academy of Sciences<\/i>.\n                                                                                                                        <\/p>\n<hr\/>\n<div class=\"article-main__explore my-4 d-print-none\">\n<p>                                                                                        Experience required: A role for vision in the development of inhibitory networks\n                                                                                    <\/p><\/div>\n<hr class=\"mb-4\"\/>\n<div class=\"article-main__more p-4\">\n                                                                                                <strong>More information:<\/strong><br \/>\n                                                Leonidas M. A. Richter et al, A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation, <i>Proceedings of the National Academy of Sciences<\/i> (2022).  <a rel=\"nofollow noopener\" target=\"_blank\" data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1073\/pnas.2116895119\">DOI: 10.1073\/pnas.2116895119<\/a><\/p><\/div>\n<p>\n                                                Provided by<br \/>\n                                                                                                    Max-Planck-Institut f\u00fcr Hirnforschung<\/p>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>                                                 <strong>Citation<\/strong>:<br \/>\n                                                 How different flavors of inhibition save the day (2022, August 24)<br \/>\n                                                 retrieved 24 August 2022<br \/>\n                                                 from https:\/\/medicalxpress.com\/<a href=\"https:\/\/buradabiliyorum.com\/en\/category\/news\/\" data-internallinksmanager029f6b8e52c=\"2\" title=\"News\" target=\"_blank\" rel=\"noopener\">news<\/a>\/2022-08-flavors-inhibition-day.html<\/p>\n<p>                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.<\/p><\/div>\n<\/p><\/div>\n<p><script id=\"facebook-jssdk\" async=\"\" src=\"https:\/\/connect.facebook.net\/en_US\/sdk.js\"><\/script><\/p>\n<blockquote><p><strong><span style=\"color: #ff6600;\">If you liked the article, do not forget to share it with your friends. Follow us on\u00a0<span style=\"color: #ff0000;\"><a style=\"color: #ff0000;\" href=\"https:\/\/news.google.com\/publications\/CAAqBwgKMLG0nwswvr63Aw\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">Google News<\/a><\/span>\u00a0too, click on the star and choose us from your favorites.<\/span><\/strong><\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\">For forums sites go to <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/forum.buradabiliyorum.com\/\" target=\"_blank\" rel=\"noopener\">Forum.BuradaBiliyorum.Com<\/a><\/span><\/strong>\n<\/p><\/blockquote>\n<blockquote>\n<p style=\"text-align: center;\"><strong>If you want to read more Like this articles, you can visit our <span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/en.buradabiliyorum.com\/science\/\" target=\"_blank\" rel=\"noopener\">Science category.<\/a><\/span><\/strong><\/p>\n<\/blockquote>\n<p><span style=\"color: black;\"><a style=\"color: #ff9900;\" href=\"https:\/\/medicalxpress.com\/news\/2022-08-flavors-inhibition-day.html\" target=\"_blank\" rel=\"noopener\">Source<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;How different flavors of inhibition save the day&#8221; Credit: Pixabay\/CC0 Public Domain During development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibitory neuron subtypes are known to influence circuit dynamics, but how they interact with plasticity is not yet fully understood. Scientists at the Max Planck Institute for Brain&#8230;<\/p>\n","protected":false},"author":1,"featured_media":487398,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2021\/neuron.jpg","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[],"class_list":["post-487397","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sciencee"],"_links":{"self":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/487397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/comments?post=487397"}],"version-history":[{"count":0,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/posts\/487397\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media\/487398"}],"wp:attachment":[{"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/media?parent=487397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/categories?post=487397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buradabiliyorum.com\/en\/wp-json\/wp\/v2\/tags?post=487397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}